Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGA8
  • Mouse genes Itga8
  • Rat genes Itga8
  • Zfish genes itga8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0045177	apical part of cell	Itga8	IDA		Mouse	PMID:10742111
Cellular Component	GO:0009986	cell surface	ITGA8	IDA		Human	PMID:24439109
Cellular Component	GO:0032591	dendritic spine membrane	Itga8	IDA		Rat	PMID:8797161|RGD:2302242
Cellular Component	GO:0005783	endoplasmic reticulum	ITGA8	IDA		Human	PMID:24439109
Cellular Component	GO:0005925	focal adhesion	ITGA8	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Itga8	IDA		Rat	PMID:8797161|RGD:2302242
Cellular Component	GO:0043204	perikaryon	Itga8	IDA		Rat	PMID:8797161|RGD:2302242
Cellular Component	GO:0005886	plasma membrane	ITGA8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Itga8	IDA		Rat	PMID:8797161|RGD:2302242
Cellular Component	GO:0098839	postsynaptic density membrane	Itga8	IDA		Rat	PMID:8797161|RGD:2302242
Biological Process	GO:0007420	brain development	Itga8	IEP		Rat	PMID:8797161|RGD:2302242
Biological Process	GO:0030030	cell projection organization	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:10742111
Biological Process	GO:0007160	cell-matrix adhesion	ITGA8	IMP		Human	PMID:24439109
Biological Process	GO:0060271	cilium assembly	itga8	IGI	ZFIN:ZDB-MRPHLNO-150211-6,ZFIN:ZDB-MRPHLNO-180405-2,ZFIN:ZDB-MRPHLNO-180405-3	Zfish	PMID:28883094
Biological Process	GO:0060271	cilium assembly	itga8	IMP	ZFIN:ZDB-MRPHLNO-180405-2,ZFIN:ZDB-MRPHLNO-180405-3	Zfish	PMID:28883094
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	itga8	IMP	ZFIN:ZDB-GENO-170209-19	Zfish	PMID:27265864
Biological Process	GO:0045184	establishment of protein localization	Itga8	IMP		Mouse	MGI:MGI:4947862|PMID:21335239
Biological Process	GO:0030198	extracellular matrix organization	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:10742111
Biological Process	GO:0042472	inner ear morphogenesis	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:10742111
Biological Process	GO:0001822	kidney development	ITGA8	IMP		Human	PMID:24439109
Biological Process	GO:0007613	memory	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:12904471
Biological Process	GO:0048333	mesodermal cell differentiation	ITGA8	IEP		Human	PMID:23154389
Biological Process	GO:0001656	metanephros development	Itga8	IGI	MGI:MGI:1345139	Mouse	PMID:17537792
Biological Process	GO:0001656	metanephros development	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:17537792
Biological Process	GO:0001656	metanephros development	Itga8	IGI	MGI:MGI:107430	Mouse	PMID:17537792
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Itga8	IDA		Mouse	MGI:MGI:4947862|PMID:21335239
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Itga8	IGI	MGI:MGI:107430	Mouse	PMID:17537792
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:17537792
Biological Process	GO:0051145	smooth muscle cell differentiation	Itga8	IDA		Mouse	MGI:MGI:4947862|PMID:21335239
Biological Process	GO:0048745	smooth muscle tissue development	Itga8	IMP		Mouse	MGI:MGI:4947862|PMID:21335239
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ITGA8	IMP		Human	PMID:24439109
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Itga8	IMP	MGI:MGI:2181699	Mouse	PMID:17537792
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Itga8	IGI	MGI:MGI:107430	Mouse	PMID:17537792

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern