Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGAL
  • Mouse genes Itgal
  • Rat genes Itgal
  • Zfish genes zmp:0000001082
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgal

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGAL	IPI	UniProtKB:P05362	Human	PMID:1448173
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGAL	IPI	UniProtKB:P13598	Human	PMID:1448173
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGAL	IPI	UniProtKB:P32942	Human	PMID:1448173
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGAL	IMP		Human	PMID:19029120
Molecular Function	GO:0030369	ICAM-3 receptor activity	ITGAL	IMP		Human	PMID:19029120
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:Q9NQ30	Human	PMID:11544294
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:Q9Y624	Human	PMID:11812992
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P05362	Human	PMID:12208882
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P05362	Human	PMID:12526797
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P08575	Human	PMID:15946252
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P05362	Human	PMID:16595626
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P05362	Human	PMID:22956999
Molecular Function	GO:0005515	protein binding	ITGAL	IPI	UniProtKB:P05161	Human	PMID:29100055
Molecular Function	GO:0044877	protein-containing complex binding	Itgal	IPI	RGD:1305581|RGD:2857	Rat	PMID:10556544|RGD:4145434
Molecular Function	GO:0044877	protein-containing complex binding	Itgal	IPI	RGD:1305581	Rat	PMID:1672643|RGD:1600245
Cellular Component	GO:0009986	cell surface	ITGAL	IDA		Human	PMID:19029120
Cellular Component	GO:0009986	cell surface	ITGAL	IDA		Human	PMID:19234460
Cellular Component	GO:0009986	cell surface	ITGAL	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Itgal	IDA		Rat	PMID:8938183|RGD:1625386
Cellular Component	GO:0005911	cell-cell junction	Itgal	IDA		Mouse	PMID:23793062
Cellular Component	GO:0009897	external side of plasma membrane	Itgal	IDA		Mouse	PMID:8043862
Cellular Component	GO:0009897	external side of plasma membrane	Itgal	IDA		Mouse	PMID:8557754
Cellular Component	GO:0070062	extracellular exosome	ITGAL	HDA		Human	PMID:20458337
Cellular Component	GO:0001772	immunological synapse	Itgal	IDA		Mouse	PMID:15064761
Cellular Component	GO:0034687	integrin alphaL-beta2 complex	ITGAL	IDA		Human	PMID:19029120
Cellular Component	GO:0016020	membrane	ITGAL	HDA		Human	PMID:19946888
Biological Process	GO:0050798	activated T cell proliferation	Itgal	IMP	MGI:MGI:2661083	Mouse	PMID:15210787
Biological Process	GO:0019722	calcium-mediated signaling	Itgal	IDA		Mouse	PMID:8117278
Biological Process	GO:0007166	cell surface receptor signaling pathway	Itgal	IDA		Mouse	PMID:8117278
Biological Process	GO:0098609	cell-cell adhesion	Itgal	IGI	UniProtKB:P11835	Mouse	MGI:MGI:6201899|PMID:12652296
Biological Process	GO:0098609	cell-cell adhesion	Itgal	IMP		Rat	PMID:8938183|RGD:1625386
Biological Process	GO:0007160	cell-matrix adhesion	ITGAL	IMP		Human	PMID:19029120
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ITGAL	IMP		Human	PMID:2477710
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ITGAL	IMP		Human	PMID:11812992
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ITGAL	IMP		Human	PMID:2477710
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itgal	IMP		Mouse	PMID:8562500
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itgal	IDA		Mouse	PMID:8117278
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itgal	IDA		Mouse	PMID:15064761
Biological Process	GO:0035683	memory T cell extravasation	ITGAL	IDA		Human	PMID:11812992
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Itgal	IDA		Mouse	PMID:8117278
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Itgal	IMP		Mouse	PMID:1346270
Biological Process	GO:0042102	positive regulation of T cell proliferation	Itgal	IMP		Mouse	PMID:1346270
Biological Process	GO:0043113	receptor clustering	ITGAL	IMP		Human	PMID:19029120
Biological Process	GO:0022407	regulation of cell-cell adhesion	Itgal	IDA		Mouse	PMID:8117278
Biological Process	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ITGAL	IMP		Human	PMID:2477710

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern