Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGAM
  • Mouse genes Itgam
  • Rat genes
  • Zfish genes itgam.1,itgam.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038024	cargo receptor activity	Itgam	IGI	UniProtKB:P01027,UniProtKB:P05555	Mouse	MGI:MGI:5319446|PMID:22438044
Molecular Function	GO:0038024	cargo receptor activity	Itgam	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Molecular Function	GO:0001851	complement component C3b binding	Itgam	IGI	UniProtKB:P01027	Mouse	MGI:MGI:5905548|PMID:20199584
Molecular Function	GO:0031072	heat shock protein binding	ITGAM	IPI	UniProtKB:P50142	Human	PMID:12496435
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Itgam	IDA		Mouse	PMID:8043862
Molecular Function	GO:0008201	heparin binding	Itgam	IDA		Mouse	PMID:8043862
Molecular Function	GO:0001846	opsonin binding	Itgam	IDA		Mouse	PMID:12163569
Molecular Function	GO:0001846	opsonin binding	Itgam	IMP	MGI:MGI:3027319	Mouse	PMID:12163569
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P05362	Human	PMID:12208882
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9BX67	Human	PMID:12208882
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P04216	Human	PMID:15004192
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9BX67	Human	PMID:15194813
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9NNX6	Human	PMID:16246332
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P05107,UniProtKB:Q8N6Q3	Human	PMID:21193407
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P21246	Human	PMID:28939773
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:O14880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P08034	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P43628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P48051	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P57054	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:P58418	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q5T7V8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q6IN84	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q8N6L0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q8N9I0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q8NBD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q96GQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9BRK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9HA82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9NQQ7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9UBT3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGAM	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Itgam	IPI	MGI:MGI:96607	Mouse	PMID:28228282
Cellular Component	GO:0009986	cell surface	ITGAM	IDA		Human	PMID:19234460
Cellular Component	GO:0009986	cell surface	ITGAM	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Itgam	IDA		Mouse	PMID:9324354
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:8788039
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:12163569
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:8552190
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:20660734
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:15845452
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:15795238
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:8043862
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:8769481
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:20228271
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:10848813
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:14609575
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:19015308
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:24029230
Cellular Component	GO:0009897	external side of plasma membrane	Itgam	IDA		Mouse	PMID:8557754
Cellular Component	GO:0070062	extracellular exosome	ITGAM	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ITGAM	IDA		Human	PMID:25645918
Cellular Component	GO:0034688	integrin alphaM-beta2 complex	Itgam	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Cellular Component	GO:0016020	membrane	Itgam	IDA		Mouse	PMID:12529407
Cellular Component	GO:0005634	nucleus	Itgam	IDA		Mouse	PMID:15138196
Cellular Component	GO:0005886	plasma membrane	ITGAM	IDA		Human	PMID:28807980
Cellular Component	GO:0005886	plasma membrane	Itgam	IDA		Mouse	MGI:MGI:1328479|PMID:9862668
Cellular Component	GO:0005886	plasma membrane	Itgam	IDA		Mouse	MGI:MGI:85444|PMID:8986723
Cellular Component	GO:0044853	plasma membrane raft	ITGAM	IDA		Human	PMID:21193407
Biological Process	GO:0050798	activated T cell proliferation	Itgam	IMP	MGI:MGI:2157556	Mouse	PMID:15210787
Biological Process	GO:0097242	amyloid-beta clearance	Itgam	IMP		Mouse	MGI:MGI:5319446|PMID:22438044
Biological Process	GO:0097242	amyloid-beta clearance	Itgam	IGI	UniProtKB:P01027	Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0097190	apoptotic signaling pathway	Itgam	IDA		Mouse	MGI:MGI:3812233|PMID:18685038
Biological Process	GO:0007155	cell adhesion	Itgam	IMP	MGI:MGI:2157556	Mouse	PMID:10528208
Biological Process	GO:0007155	cell adhesion	Itgam	IGI	MGI:MGI:1933825	Mouse	PMID:19342649
Biological Process	GO:0007155	cell adhesion	Itgam	IGI	MGI:MGI:96611	Mouse	PMID:19342649
Biological Process	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	Itgam	IMP		Mouse	MGI:MGI:6189359|PMID:22632727
Biological Process	GO:0098609	cell-cell adhesion	Itgam	IGI	MGI:MGI:1933825	Mouse	PMID:16093349
Biological Process	GO:0098609	cell-cell adhesion	Itgam	IGI	MGI:MGI:1933820	Mouse	PMID:16093349
Biological Process	GO:0098609	cell-cell adhesion	Itgam	IGI	MGI:MGI:96611	Mouse	PMID:16093349
Biological Process	GO:0045123	cellular extravasation	Itgam	IMP	MGI:MGI:2157556	Mouse	PMID:10528208
Biological Process	GO:0150062	complement-mediated synapse pruning	Itgam	IMP		Mouse	MGI:MGI:6189359|PMID:22632727
Biological Process	GO:0010668	ectodermal cell differentiation	ITGAM	IEP		Human	PMID:23154389
Biological Process	GO:0030900	forebrain development	Itgam	IDA		Mouse	MGI:MGI:3812233|PMID:18685038
Biological Process	GO:0061756	leukocyte adhesion to vascular endothelial cell	Itgam	IMP		Mouse	MGI:MGI:85444|PMID:8986723
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itgam	IMP		Mouse	PMID:8562500
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Itgam	IMP	MGI:MGI:1931533	Mouse	PMID:23550035
Biological Process	GO:0014005	microglia development	Itgam	IDA		Mouse	PMID:20578039
Biological Process	GO:0001774	microglial cell activation	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	Itgam	IDA		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0001781	neutrophil apoptotic process	Itgam	IMP		Mouse	MGI:MGI:85444|PMID:8986723
Biological Process	GO:0030593	neutrophil chemotaxis	Itgam	IMP	MGI:MGI:2157556	Mouse	PMID:10528208
Biological Process	GO:0006909	phagocytosis	Itgam	IMP		Mouse	MGI:MGI:85444|PMID:8986723
Biological Process	GO:0006911	phagocytosis, engulfment	Itgam	IMP		Mouse	MGI:MGI:5319446|PMID:22438044
Biological Process	GO:0006911	phagocytosis, engulfment	Itgam	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0006911	phagocytosis, engulfment	Itgam	IMP		Mouse	MGI:MGI:6189359|PMID:22632727
Biological Process	GO:0110090	positive regulation of hippocampal neuron apoptotic process	Itgam	IDA		Mouse	MGI:MGI:3812233|PMID:18685038
Biological Process	GO:0060376	positive regulation of mast cell differentiation	Itgam	IMP		Mouse	MGI:MGI:1328479|PMID:9862668
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	Itgam	IMP		Mouse	MGI:MGI:3812233|PMID:18685038
Biological Process	GO:1901216	positive regulation of neuron death	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0043315	positive regulation of neutrophil degranulation	ITGAM	IGI	UniProtKB:P05107,UniProtKB:Q8N6Q3	Human	PMID:21193407
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:2000363	positive regulation of prostaglandin-E synthase activity	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ITGAM	IGI	UniProtKB:P05107,UniProtKB:Q8N6Q3	Human	PMID:21193407
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Itgam	IMP		Mouse	MGI:MGI:3814938|PMID:18981141
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Itgam	IDA		Mouse	MGI:MGI:3812233|PMID:18685038
Biological Process	GO:0006898	receptor-mediated endocytosis	Itgam	IMP		Mouse	MGI:MGI:5319446|PMID:22438044
Biological Process	GO:0006898	receptor-mediated endocytosis	Itgam	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0150064	vertebrate eye-specific patterning	Itgam	IMP		Mouse	MGI:MGI:6189359|PMID:22632727

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern