Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itgav

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGAV
- Mouse genes Itgav
- Rat genes Itgav
- Zfish genes itgav
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgav

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019960	C-X3-C chemokine binding	ITGAV	IDA		Human	PMID:23125415
Molecular Function	GO:0050840	extracellular matrix binding	ITGAV	IDA		Human	PMID:22505472
Molecular Function	GO:1990430	extracellular matrix protein binding	ITGAV	IDA		Human	PMID:7525578
Molecular Function	GO:0017134	fibroblast growth factor binding	ITGAV	IDA		Human	PMID:18441324
Molecular Function	GO:0001968	fibronectin binding	ITGAV	IDA		Human	PMID:24658351
Molecular Function	GO:0031994	insulin-like growth factor I binding	ITGAV	IDA		Human	PMID:19578119
Molecular Function	GO:0005178	integrin binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:20826760
Molecular Function	GO:0005178	integrin binding	Itgav	IPI	UniProtKB:O70309	Mouse	MGI:MGI:5285150\|PMID:20826760
Molecular Function	GO:0038132	neuregulin binding	ITGAV	IDA		Human	PMID:20682778
Molecular Function	GO:0001846	opsonin binding	Itgav	IDA		Mouse	MGI:MGI:5285150\|PMID:20826760
Molecular Function	GO:0002020	protease binding	ITGAV	IDA		Human	PMID:22505472
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:11546839
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:Q9Y5C1	Human	PMID:11877390
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:11884718
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P48745	Human	PMID:12695522
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P35555	Human	PMID:12807887
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:15299032
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P48745	Human	PMID:15611078
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:16099422
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:1694173
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P18084	Human	PMID:1694173
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P35555	Human	PMID:17158881
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P57735	Human	PMID:17925226
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:20639902
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P18564	Human	PMID:21677751
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:22178926
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:Q99828	Human	PMID:24011356
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106	Human	PMID:24658351
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P18564	Human	PMID:25383667
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P18564	Human	PMID:28534487
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P05106,UniProtKB:P29965	Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:P54725	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITGAV	IPI	UniProtKB:Q38SD2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Itgav	IPI	RGD:628868	Rat	PMID:1585837\|RGD:8693379
Molecular Function	GO:0005515	protein binding	Itgav	IPI	RGD:628869	Rat	PMID:17684062\|RGD:2302243
Molecular Function	GO:0005515	protein binding	itgav	IPI	UniProtKB:Q3LTM5	Zfish	PMID:17626277
Molecular Function	GO:0005080	protein kinase C binding	Itgav	IDA		Mouse	MGI:MGI:5284791\|PMID:16014375
Molecular Function	GO:0005102	signaling receptor binding	Itgav	IPI	RGD:2277	Rat	PMID:21969374\|RGD:7205691
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ITGAV	IDA		Human	PMID:18395422
Cellular Component	GO:0035868	alphav-beta3 integrin-HMGB1 complex	ITGAV	IDA		Human	PMID:20826760
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	ITGAV	IDA		Human	PMID:19578119
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:1918072
Cellular Component	GO:0009986	cell surface	ITGAV	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:21310825
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:22505472
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:23154389
Cellular Component	GO:0009986	cell surface	ITGAV	HDA		Human	PMID:23658023
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0009986	cell surface	ITGAV	IDA		Human	PMID:7525578
Cellular Component	GO:0005829	cytosol	ITGAV	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Itgav	IDA		Mouse	PMID:8557754
Cellular Component	GO:0009897	external side of plasma membrane	Itgav	IDA		Mouse	PMID:9553049
Cellular Component	GO:0070062	extracellular exosome	ITGAV	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ITGAV	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ITGAV	HDA		Human	PMID:23533145
Cellular Component	GO:0031527	filopodium membrane	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0005925	focal adhesion	ITGAV	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	ITGAV	IDA		Human	PMID:17158881
Cellular Component	GO:0005925	focal adhesion	ITGAV	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0005925	focal adhesion	ITGAV	IDA		Human	PMID:29162887
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:20826760
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:22505472
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:23726972
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:24658351
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ITGAV	IDA		Human	PMID:31331973
Cellular Component	GO:0034684	integrin alphav-beta5 complex	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0034684	integrin alphav-beta5 complex	Itgav	IDA		Mouse	MGI:MGI:5285150\|PMID:20826760
Cellular Component	GO:0034685	integrin alphav-beta6 complex	ITGAV	IDA		Human	PMID:22278742
Cellular Component	GO:0034685	integrin alphav-beta6 complex	Itgav	IDA		Mouse	MGI:MGI:5571208\|PMID:24681597
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGAV	IPI		Human	PMID:30061598
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGAV	IDA		Human	PMID:1918072
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGAV	IDA		Human	PMID:22278742
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGAV	IDA		Human	PMID:7525578
Cellular Component	GO:0008305	integrin complex	ITGAV	IDA		Human	PMID:15215180
Cellular Component	GO:0008305	integrin complex	itgav	IDA		Zfish	PMID:17626277
Cellular Component	GO:0031258	lamellipodium membrane	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0016020	membrane	Itgav	IDA		Mouse	MGI:MGI:4422103\|PMID:20151413
Cellular Component	GO:0031528	microvillus membrane	ITGAV	IDA		Human	PMID:25063885
Cellular Component	GO:0005886	plasma membrane	ITGAV	IDA		Human	PMID:21310825
Cellular Component	GO:0005886	plasma membrane	Itgav	IDA		Mouse	PMID:14566019
Cellular Component	GO:0032587	ruffle membrane	ITGAV	IDA		Human	PMID:25063885
Biological Process	GO:0001525	angiogenesis	ITGAV	IEP		Human	PMID:11866539
Biological Process	GO:0001525	angiogenesis	Itgav	IEP		Rat	PMID:12926533\|RGD:1582460
Biological Process	GO:0001525	angiogenesis	itgav	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	ITGAV	IMP		Human	PMID:23726972
Biological Process	GO:0043277	apoptotic cell clearance	ITGAV	IGI	UniProtKB:P43406	Human	PMID:20826760
Biological Process	GO:0043277	apoptotic cell clearance	Itgav	IGI	UniProtKB:P06756	Mouse	MGI:MGI:5285150\|PMID:20826760
Biological Process	GO:0043277	apoptotic cell clearance	Itgav	IDA		Mouse	MGI:MGI:5285150\|PMID:20826760
Biological Process	GO:0043277	apoptotic cell clearance	Itgav	IMP		Mouse	PMID:15647754
Biological Process	GO:0090245	axis elongation involved in somitogenesis	itgav	IMP	ZFIN:ZDB-MRPHLNO-050620-1,ZFIN:ZDB-MRPHLNO-120823-8	Zfish	PMID:23810535
Biological Process	GO:0001568	blood vessel development	Itgav	IMP	MGI:MGI:1857889	Mouse	PMID:12370313
Biological Process	GO:0001568	blood vessel development	itgav	IMP	ZFIN:ZDB-MRPHLNO-120823-8	Zfish	PMID:22206757
Biological Process	GO:0001568	blood vessel development	itgav	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0001568	blood vessel development	itgav	IMP	ZFIN:ZDB-MRPHLNO-120823-7	Zfish	PMID:22206757
Biological Process	GO:0070588	calcium ion transmembrane transport	ITGAV	IDA		Human	PMID:18395422
Biological Process	GO:0051216	cartilage development	itgav	IGI	ZFIN:ZDB-GENO-221208-10	Zfish	PMID:35732225
Biological Process	GO:0051216	cartilage development	itgav	IGI	ZFIN:ZDB-GENO-221208-9	Zfish	PMID:35732225
Biological Process	GO:0007155	cell adhesion	ITGAV	IDA		Human	PMID:10218736
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGAV	IDA		Human	PMID:12807887
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGAV	IDA		Human	PMID:17158881
Biological Process	GO:0033627	cell adhesion mediated by integrin	Itgav	IDA		Mouse	MGI:MGI:5571208\|PMID:24681597
Biological Process	GO:0016477	cell migration	ITGAV	IMP		Human	PMID:26934001
Biological Process	GO:0016477	cell migration	Itgav	IMP		Rat	PMID:16565398\|RGD:1582456
Biological Process	GO:0016477	cell migration	itgav	IGI	ZFIN:ZDB-MRPHLNO-080708-1,ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:24599960
Biological Process	GO:0016477	cell migration	itgav	IGI	ZFIN:ZDB-MRPHLNO-080708-2,ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:24599960
Biological Process	GO:0042074	cell migration involved in gastrulation	itgav	IMP	ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:20843856
Biological Process	GO:0007160	cell-matrix adhesion	ITGAV	IMP		Human	PMID:24658351
Biological Process	GO:0007160	cell-matrix adhesion	ITGAV	IMP		Human	PMID:7525578
Biological Process	GO:0031589	cell-substrate adhesion	ITGAV	IMP		Human	PMID:19933311
Biological Process	GO:0001706	endoderm formation	itgav	IGI	ZFIN:ZDB-GENO-221208-5	Zfish	PMID:35732225
Biological Process	GO:0035987	endodermal cell differentiation	ITGAV	IMP		Human	PMID:23154389
Biological Process	GO:0001935	endothelial cell proliferation	itgav	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Itgav	IDA		Mouse	MGI:MGI:5284791\|PMID:16014375
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Itgav	IDA		Mouse	MGI:MGI:3530680\|PMID:15591537
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGAV	IMP		Human	PMID:20563599
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGAV	IDA		Human	PMID:11970960
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGAV	IMP		Human	PMID:26934001
Biological Process	GO:0070121	Kupffer's vesicle development	itgav	IMP	ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:20843856
Biological Process	GO:0050919	negative chemotaxis	ITGAV	IMP		Human	PMID:23726972
Biological Process	GO:2000536	negative regulation of entry of bacterium into host cell	ITGAV	IDA		Human	PMID:10570297
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ITGAV	IMP		Human	PMID:10708943
Biological Process	GO:0010888	negative regulation of lipid storage	ITGAV	IMP		Human	PMID:15215180
Biological Process	GO:0032369	negative regulation of lipid transport	ITGAV	IMP		Human	PMID:15215180
Biological Process	GO:0050748	negative regulation of lipoprotein metabolic process	ITGAV	IMP		Human	PMID:15215180
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ITGAV	IMP		Human	PMID:15215180
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	ITGAV	IMP		Human	PMID:15215180
Biological Process	GO:0060037	pharyngeal system development	itgav	IGI	ZFIN:ZDB-GENO-221208-10	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itgav	IGI	ZFIN:ZDB-GENO-221208-9	Zfish	PMID:35732225
Biological Process	GO:0060037	pharyngeal system development	itgav	IGI	ZFIN:ZDB-GENO-221208-5	Zfish	PMID:35732225
Biological Process	GO:0045785	positive regulation of cell adhesion	ITGAV	IDA		Human	PMID:10708943
Biological Process	GO:0030335	positive regulation of cell migration	Itgav	IMP		Mouse	MGI:MGI:5009350\|PMID:20675382
Biological Process	GO:0008284	positive regulation of cell population proliferation	ITGAV	IDA		Human	PMID:19578119
Biological Process	GO:0008284	positive regulation of cell population proliferation	Itgav	IDA		Rat	PMID:11953315\|RGD:1582459
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itgav	IDA		Rat	PMID:17072743\|RGD:1582455
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ITGAV	IMP		Human	PMID:26934001
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Itgav	IMP		Mouse	MGI:MGI:5009350\|PMID:20675382
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	ITGAV	IMP		Human	PMID:26934001
Biological Process	GO:0050764	regulation of phagocytosis	ITGAV	IDA		Human	PMID:10570297
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ITGAV	IDA		Human	PMID:11970960
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ITGAV	IDA		Human	PMID:22278742
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ITGAV	IDA		Human	PMID:24658351
Biological Process	GO:0071604	transforming growth factor beta production	Itgav	IDA		Mouse	MGI:MGI:5571208\|PMID:24681597
Biological Process	GO:0001570	vasculogenesis	Itgav	IEP		Rat	PMID:12926533\|RGD:1582460
Biological Process	GO:0046718	viral entry into host cell	ITGAV	IMP		Human	PMID:25063885

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.