Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGB2
  • Mouse genes Itgb2
  • Rat genes Itgb2
  • Zfish genes itgb2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Itgb2	IMP		Mouse	MGI:MGI:5927441|PMID:18981818
Molecular Function	GO:0038024	cargo receptor activity	Itgb2	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Molecular Function	GO:0050839	cell adhesion molecule binding	ITGB2	IMP		Human	PMID:19029120
Molecular Function	GO:0050839	cell adhesion molecule binding	Itgb2	IMP		Rat	PMID:16825578|RGD:1582375
Molecular Function	GO:0001851	complement component C3b binding	Itgb2	IGI	UniProtKB:P01027	Mouse	MGI:MGI:5905548|PMID:20199584
Molecular Function	GO:0031072	heat shock protein binding	ITGB2	IPI	UniProtKB:P50142	Human	PMID:12496435
Molecular Function	GO:0030369	ICAM-3 receptor activity	ITGB2	IMP		Human	PMID:19029120
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9BX67	Human	PMID:12208882
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P60033	Human	PMID:12796480
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q15762	Human	PMID:16831868
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P35241	Human	PMID:17321526
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q15582	Human	PMID:18083624
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P00519	Human	PMID:19234221
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9Y4G6	Human	PMID:19234221
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P21333	Human	PMID:19828450
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P20702	Human	PMID:20033057
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P13796	Human	PMID:20183869
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P20702	Human	PMID:20679211
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P11215,UniProtKB:Q8N6Q3	Human	PMID:21193407
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q8N6Q3	Human	PMID:28807980
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:O75841	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q96CE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9BQE5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9GZW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9H2K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q9UN30-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q14145	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ITGB2	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Itgb2	IPI	UniProtKB:P09055,UniProtKB:P20491,UniProtKB:P35762,UniProtKB:Q08857|UniProtKB:P09055,UniProtKB:P20491,UniProtKB:P40240,UniProtKB:Q08857	Mouse	MGI:MGI:5700288|PMID:23395392
Molecular Function	GO:0005515	protein binding	Itgb2	IPI	UniProtKB:Q8K1B8	Mouse	MGI:MGI:3838441|PMID:19234461
Molecular Function	GO:0019901	protein kinase binding	ITGB2	IPI	UniProtKB:P43405	Human	PMID:12885943
Molecular Function	GO:0044877	protein-containing complex binding	Itgb2	IPI	RGD:631424|RGD:2857	Rat	PMID:10556544|RGD:4145434
Molecular Function	GO:0044877	protein-containing complex binding	Itgb2	IPI	RGD:2926	Rat	PMID:1672643|RGD:1600245
Molecular Function	GO:0044877	protein-containing complex binding	Itgb2	IPI	RGD:631424	Rat	PMID:1672643|RGD:1600245
Molecular Function	GO:0044877	protein-containing complex binding	Itgb2	IPI	RGD:71075	Rat	PMID:1672643|RGD:1600245
Cellular Component	GO:0009986	cell surface	ITGB2	IDA		Human	PMID:19029120
Cellular Component	GO:0009986	cell surface	ITGB2	IDA		Human	PMID:19234460
Cellular Component	GO:0009986	cell surface	ITGB2	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGB2	IDA		Human	PMID:23620790
Cellular Component	GO:0009986	cell surface	ITGB2	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Itgb2	IDA		Mouse	PMID:17023661
Cellular Component	GO:0009986	cell surface	Itgb2	IDA		Rat	PMID:16825578|RGD:1582375
Cellular Component	GO:0009986	cell surface	Itgb2	IDA		Rat	PMID:8938183|RGD:1625386
Cellular Component	GO:0009897	external side of plasma membrane	Itgb2	IDA		Mouse	PMID:19299737
Cellular Component	GO:0070062	extracellular exosome	ITGB2	HDA		Human	PMID:20458337
Cellular Component	GO:1903561	extracellular vesicle	ITGB2	HDA		Human	PMID:24769233
Cellular Component	GO:0034687	integrin alphaL-beta2 complex	ITGB2	IDA		Human	PMID:19029120
Cellular Component	GO:0034688	integrin alphaM-beta2 complex	Itgb2	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Cellular Component	GO:0016020	membrane	ITGB2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Itgb2	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Cellular Component	GO:0016020	membrane	Itgb2	IDA		Mouse	PMID:10601245
Cellular Component	GO:0045121	membrane raft	Itgb2	IDA		Mouse	PMID:10601245
Cellular Component	GO:0005886	plasma membrane	ITGB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Itgb2	IDA		Rat	PMID:14595007|RGD:1582374
Cellular Component	GO:0044853	plasma membrane raft	ITGB2	IDA		Human	PMID:21193407
Cellular Component	GO:0043235	receptor complex	ITGB2	IDA		Human	PMID:23382219
Biological Process	GO:0050798	activated T cell proliferation	Itgb2	IMP	MGI:MGI:1861705	Mouse	PMID:15210787
Biological Process	GO:0007568	aging	Itgb2	IEP		Rat	PMID:22206492|RGD:6482194
Biological Process	GO:0097242	amyloid-beta clearance	Itgb2	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0007155	cell adhesion	ITGB2	IDA		Human	PMID:19703720
Biological Process	GO:0007155	cell adhesion	Itgb2	IGI	MGI:MGI:96607	Mouse	PMID:19342649
Biological Process	GO:0007155	cell adhesion	Itgb2	IGI	MGI:MGI:1933825	Mouse	PMID:19342649
Biological Process	GO:0007155	cell adhesion	Itgb2	IMP	MGI:MGI:1861705	Mouse	PMID:10528208
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IGI	UniProtKB:P24063	Mouse	MGI:MGI:6201899|PMID:12652296
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IGI	MGI:MGI:1933825	Mouse	PMID:16093349
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IGI	MGI:MGI:1933820	Mouse	PMID:16093349
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IGI	MGI:MGI:96607	Mouse	PMID:16093349
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IMP		Rat	PMID:16825578|RGD:1582375
Biological Process	GO:0098609	cell-cell adhesion	Itgb2	IMP		Rat	PMID:8938183|RGD:1625386
Biological Process	GO:0007160	cell-matrix adhesion	ITGB2	IMP		Human	PMID:19029120
Biological Process	GO:0045123	cellular extravasation	Itgb2	IMP	MGI:MGI:1861705	Mouse	PMID:10528208
Biological Process	GO:0045123	cellular extravasation	Itgb2	IMP		Rat	PMID:10363598|RGD:1600231
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Itgb2	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Biological Process	GO:0060216	definitive hemopoiesis	itgb2	IMP	ZFIN:ZDB-MRPHLNO-191003-3	Zfish	PMID:31042481
Biological Process	GO:0035987	endodermal cell differentiation	ITGB2	IEP		Human	PMID:23154389
Biological Process	GO:0043542	endothelial cell migration	Itgb2	IMP		Rat	PMID:16825578|RGD:1582375
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ITGB2	IMP		Human	PMID:20563599
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGB2	IMP		Human	PMID:28807980
Biological Process	GO:0007229	integrin-mediated signaling pathway	Itgb2	IDA		Mouse	PMID:15249579
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ITGB2	IDA		Human	PMID:12885943
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Itgb2	IMP		Rat	PMID:11804664|RGD:1600228
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Itgb2	IMP		Rat	PMID:10363598|RGD:1600231
Biological Process	GO:0030101	natural killer cell activation	Itgb2	IMP		Rat	PMID:9413744|RGD:1600235
Biological Process	GO:0030593	neutrophil chemotaxis	ITGB2	IDA		Human	PMID:12885943
Biological Process	GO:0030593	neutrophil chemotaxis	Itgb2	IMP	MGI:MGI:1861705	Mouse	PMID:10528208
Biological Process	GO:1990266	neutrophil migration	ITGB2	IMP		Human	PMID:28807980
Biological Process	GO:0006911	phagocytosis, engulfment	Itgb2	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0045766	positive regulation of angiogenesis	Itgb2	IMP		Rat	PMID:16825578|RGD:1582375
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	Itgb2	IMP		Mouse	MGI:MGI:5568278|PMID:24458438
Biological Process	GO:0043315	positive regulation of neutrophil degranulation	ITGB2	IGI	UniProtKB:P11215,UniProtKB:Q8N6Q3	Human	PMID:21193407
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Itgb2	IMP		Rat	PMID:9062344|RGD:1600239
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Itgb2	IMP		Rat	PMID:9062344|RGD:1600239
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ITGB2	IGI	UniProtKB:P11215,UniProtKB:Q8N6Q3	Human	PMID:21193407
Biological Process	GO:0043113	receptor clustering	ITGB2	IMP		Human	PMID:19029120
Biological Process	GO:0031623	receptor internalization	Itgb2	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Biological Process	GO:0006898	receptor-mediated endocytosis	Itgb2	IMP		Mouse	MGI:MGI:5905548|PMID:20199584
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ITGB2	IDA		Human	PMID:12885943

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern