Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGB4
  • Mouse genes Itgb4
  • Rat genes Itgb4
  • Zfish genes itgb4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	ITGB4	IPI	UniProtKB:O95136	Human	PMID:24851274
Molecular Function	GO:0001664	G protein-coupled receptor binding	ITGB4	IPI	UniProtKB:Q99500	Human	PMID:24851274
Molecular Function	GO:0031994	insulin-like growth factor I binding	ITGB4	IDA		Human	PMID:22351760
Molecular Function	GO:0038132	neuregulin binding	ITGB4	IDA		Human	PMID:20682778
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q03001	Human	PMID:11375975
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q03001	Human	PMID:12482924
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q03001-3	Human	PMID:12482924
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q9UMD9	Human	PMID:12482924
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q15149	Human	PMID:19242489
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:P63000	Human	PMID:19403692
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q96B67	Human	PMID:20603614
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:P23229	Human	PMID:21880726
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q8R5M8-2	Human	PMID:21880726
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:P20073	Human	PMID:24007983
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:O95136	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q99500	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q9QXS1-3	Human	PMID:25703379
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:P23229	Human	PMID:2649503
Molecular Function	GO:0005515	protein binding	ITGB4	IPI	UniProtKB:Q05397	Human	PMID:27178753
Molecular Function	GO:0005515	protein binding	Itgb4	IPI	PR:P70227	Mouse	PMID:29315582
Molecular Function	GO:0005515	protein binding	Itgb4	IPI	PR:A2A863	Mouse	PMID:16436605
Molecular Function	GO:0005515	protein binding	Itgb4	IPI	PR:P16646	Mouse	PMID:29315582
Molecular Function	GO:0005515	protein binding	Itgb4	IPI	PR:P16646	Mouse	PMID:16436605
Molecular Function	GO:0005515	protein binding	Itgb4	IPI	PR:Q61739	Mouse	PMID:16436605
Cellular Component	GO:0009925	basal plasma membrane	Itgb4	IDA		Mouse	PMID:21464233
Cellular Component	GO:0009925	basal plasma membrane	Itgb4	IDA		Mouse	PMID:11891657
Cellular Component	GO:0005604	basement membrane	Itgb4	IDA		Mouse	PMID:17011173
Cellular Component	GO:0005938	cell cortex	Itgb4	IDA		Rat	PMID:16409251|RGD:1581345
Cellular Component	GO:0030054	cell junction	ITGB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031252	cell leading edge	ITGB4	IDA		Human	PMID:19403692
Cellular Component	GO:0009986	cell surface	ITGB4	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGB4	IDA		Human	PMID:21310825
Cellular Component	GO:0009986	cell surface	Itgb4	IDA		Mouse	PMID:16436605
Cellular Component	GO:0005737	cytoplasm	Itgb4	IDA		Rat	PMID:16409251|RGD:1581345
Cellular Component	GO:0070062	extracellular exosome	ITGB4	HDA		Human	PMID:19199708
Cellular Component	GO:0098978	glutamatergic synapse	Itgb4	IDA		Rat	PMID:27518800|RGD:155230752
Cellular Component	GO:0030056	hemidesmosome	ITGB4	IDA		Human	PMID:12482924
Cellular Component	GO:0030056	hemidesmosome	Itgb4	IDA		Mouse	PMID:22274697
Cellular Component	GO:0030056	hemidesmosome	Itgb4	IDA		Mouse	PMID:21606200
Cellular Component	GO:0008305	integrin complex	Itgb4	IDA		Mouse	PMID:8707838
Cellular Component	GO:0016020	membrane	Itgb4	IDA		Rat	PMID:16409251|RGD:1581345
Cellular Component	GO:0031965	nuclear membrane	ITGB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	ITGB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ITGB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ITGB4	IDA		Human	PMID:21310825
Cellular Component	GO:0005886	plasma membrane	ITGB4	IDA		Human	PMID:24851274
Cellular Component	GO:0045211	postsynaptic membrane	Itgb4	IDA		Rat	PMID:27518800|RGD:155230752
Cellular Component	GO:0043235	receptor complex	ITGB4	IDA		Human	PMID:23382219
Biological Process	GO:0006914	autophagy	ITGB4	IMP		Human	PMID:24007983
Biological Process	GO:0007155	cell adhesion	Itgb4	IMP	MGI:MGI:2183630	Mouse	PMID:8707838
Biological Process	GO:0048870	cell motility	ITGB4	IMP		Human	PMID:19403692
Biological Process	GO:0007160	cell-matrix adhesion	ITGB4	IMP		Human	PMID:23496044
Biological Process	GO:0046847	filopodium assembly	Itgb4	IMP		Mouse	PMID:16365040
Biological Process	GO:0031581	hemidesmosome assembly	ITGB4	IDA		Human	PMID:12482924
Biological Process	GO:0031581	hemidesmosome assembly	ITGB4	IMP		Human	PMID:23496044
Biological Process	GO:0048333	mesodermal cell differentiation	ITGB4	IEP		Human	PMID:23154389
Biological Process	GO:0022011	myelination in peripheral nervous system	Itgb4	IGI	MGI:MGI:97631	Mouse	PMID:29315582
Biological Process	GO:0035878	nail development	ITGB4	IMP		Human	PMID:23496044
Biological Process	GO:0032290	peripheral nervous system myelin formation	Itgb4	IGI	MGI:MGI:97631	Mouse	PMID:29315582
Biological Process	GO:0009611	response to wounding	ITGB4	IDA		Human	PMID:19403692
Biological Process	GO:0043589	skin morphogenesis	ITGB4	IMP		Human	PMID:23496044
Biological Process	GO:0061450	trophoblast cell migration	Itgb4	IMP	MGI:MGI:4331862	Mouse	PMID:21606200

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern