Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGB6
  • Mouse genes Itgb6
  • Rat genes Itgb6
  • Zfish genes itgb6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgb6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	Itgb6	IPI	PR:P11688	Mouse	PMID:8601592
Molecular Function	GO:0005515	protein binding	ITGB6	IPI	UniProtKB:P35555	Human	PMID:17158881
Molecular Function	GO:0005515	protein binding	ITGB6	IPI	UniProtKB:P06756	Human	PMID:21677751
Molecular Function	GO:0005515	protein binding	ITGB6	IPI	UniProtKB:P06756	Human	PMID:25383667
Molecular Function	GO:0005515	protein binding	ITGB6	IPI	UniProtKB:P06756	Human	PMID:28534487
Cellular Component	GO:0030054	cell junction	ITGB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Itgb6	IDA		Mouse	PMID:16710477
Cellular Component	GO:0005813	centrosome	ITGB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Itgb6	IDA		Mouse	PMID:9553049
Cellular Component	GO:0005925	focal adhesion	ITGB6	IDA		Human	PMID:17158881
Cellular Component	GO:0034685	integrin alphav-beta6 complex	ITGB6	IDA		Human	PMID:22278742
Cellular Component	GO:0034685	integrin alphav-beta6 complex	Itgb6	IDA		Mouse	MGI:MGI:5571208|PMID:24681597
Cellular Component	GO:0005654	nucleoplasm	ITGB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043235	receptor complex	ITGB6	IDA		Human	PMID:23382219
Biological Process	GO:0060348	bone development	Itgb6	IMP		Mouse	PMID:30467097
Biological Process	GO:0060435	bronchiole development	Itgb6	IDA		Mouse	PMID:12634787
Biological Process	GO:0060435	bronchiole development	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0033627	cell adhesion mediated by integrin	ITGB6	IDA		Human	PMID:17158881
Biological Process	GO:0033627	cell adhesion mediated by integrin	Itgb6	IDA		Mouse	MGI:MGI:5571208|PMID:24681597
Biological Process	GO:0000902	cell morphogenesis	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:17641300
Biological Process	GO:0007160	cell-matrix adhesion	Itgb6	IMP		Mouse	PMID:23264742
Biological Process	GO:0071479	cellular response to ionizing radiation	Itgb6	IDA		Mouse	PMID:17916808
Biological Process	GO:0002534	cytokine production involved in inflammatory response	Itgb6	IMP		Mouse	PMID:30467097
Biological Process	GO:0070166	enamel mineralization	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:23264742
Biological Process	GO:0010467	gene expression	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0010467	gene expression	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:23264742
Biological Process	GO:0010467	gene expression	Itgb6	IMP		Mouse	PMID:30467097
Biological Process	GO:0060022	hard palate development	Itgb6	IGI	MGI:MGI:1338035	Mouse	PMID:19118215
Biological Process	GO:0006955	immune response	Itgb6	IGI	MGI:MGI:1338035	Mouse	PMID:19118215
Biological Process	GO:0006954	inflammatory response	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:15963261
Biological Process	GO:0061520	Langerhans cell differentiation	Itgb6	IGI	MGI:MGI:1338035	Mouse	PMID:19118215
Biological Process	GO:0048286	lung alveolus development	Itgb6	IDA		Mouse	PMID:12634787
Biological Process	GO:0048286	lung alveolus development	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0055091	phospholipid homeostasis	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:17641300
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ITGB6	IDA		Human	PMID:22278742
Biological Process	GO:0009615	response to virus	Itgb6	IGI	MGI:MGI:1338035	Mouse	PMID:30952606
Biological Process	GO:0009611	response to wounding	Itgb6	IDA		Mouse	PMID:24488487
Biological Process	GO:0009611	response to wounding	Itgb6	IDA		Mouse	PMID:24319098
Biological Process	GO:0043588	skin development	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0060395	SMAD protein signal transduction	Itgb6	IDA		Mouse	PMID:30467097
Biological Process	GO:0043129	surfactant homeostasis	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:17641300
Biological Process	GO:0071604	transforming growth factor beta production	Itgb6	IDA		Mouse	MGI:MGI:5571208|PMID:24681597
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Itgb6	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Itgb6	IGI	MGI:MGI:1338035	Mouse	PMID:30952606
Biological Process	GO:0042060	wound healing	Itgb6	IMP		Mouse	PMID:30500364

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern