Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITGB8
  • Mouse genes Itgb8
  • Rat genes Itgb8
  • Zfish genes itgb8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itgb8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990430	extracellular matrix protein binding	ITGB8	IDA		Human	PMID:7525578
Molecular Function	GO:0005102	signaling receptor binding	Itgb8	IPI	RGD:2277	Rat	PMID:21969374|RGD:7205691
Cellular Component	GO:0009986	cell surface	ITGB8	IDA		Human	PMID:1918072
Cellular Component	GO:0009986	cell surface	ITGB8	IDA		Human	PMID:7525578
Cellular Component	GO:0070062	extracellular exosome	ITGB8	HDA		Human	PMID:19056867
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGB8	IPI		Human	PMID:30061598
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGB8	IDA		Human	PMID:1918072
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ITGB8	IDA		Human	PMID:7525578
Cellular Component	GO:0034686	integrin alphav-beta8 complex	Itgb8	IDA		Mouse	MGI:MGI:5490445|PMID:22278742
Biological Process	GO:0001525	angiogenesis	itgb8	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0001568	blood vessel development	itgb8	IMP	ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0001568	blood vessel development	itgb8	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0001568	blood vessel development	itgb8	IMP	ZFIN:ZDB-MRPHLNO-120907-2	Zfish	PMID:22206757
Biological Process	GO:0051216	cartilage development	ITGB8	IMP		Human	PMID:24312400
Biological Process	GO:0001935	endothelial cell proliferation	itgb8	IGI	ZFIN:ZDB-MRPHLNO-120823-7,ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:22206757
Biological Process	GO:0001573	ganglioside metabolic process	Itgb8	IMP	MGI:MGI:2180548	Mouse	PMID:16251442
Biological Process	GO:0060022	hard palate development	Itgb8	IGI	MGI:MGI:96615	Mouse	PMID:19118215
Biological Process	GO:0006955	immune response	Itgb8	IGI	MGI:MGI:96615	Mouse	PMID:19118215
Biological Process	GO:0007229	integrin-mediated signaling pathway	ITGB8	IDA		Human	PMID:11970960
Biological Process	GO:0061520	Langerhans cell differentiation	Itgb8	IGI	MGI:MGI:96615	Mouse	PMID:19118215
Biological Process	GO:0010629	negative regulation of gene expression	ITGB8	IMP		Human	PMID:24312400
Biological Process	GO:0045766	positive regulation of angiogenesis	ITGB8	IMP		Human	PMID:25801897
Biological Process	GO:0010628	positive regulation of gene expression	ITGB8	IMP		Human	PMID:24312400
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ITGB8	IDA		Human	PMID:11970960
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	Itgb8	IDA		Mouse	MGI:MGI:5490445|PMID:22278742
Biological Process	GO:0009615	response to virus	Itgb8	IGI	MGI:MGI:96615	Mouse	PMID:30952606
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Itgb8	IGI	MGI:MGI:96615	Mouse	PMID:30952606
Biological Process	GO:0001944	vasculature development	itgb8	IGI	ZFIN:ZDB-MRPHLNO-050906-3,ZFIN:ZDB-MRPHLNO-170503-1	Zfish	PMID:26586223
Biological Process	GO:0001944	vasculature development	itgb8	IGI	ZFIN:ZDB-MRPHLNO-120907-1,ZFIN:ZDB-MRPHLNO-130827-3	Zfish	PMID:26586223
Biological Process	GO:0001944	vasculature development	itgb8	IMP	ZFIN:ZDB-MRPHLNO-170503-1	Zfish	PMID:26586223
Biological Process	GO:0001944	vasculature development	itgb8	IMP	ZFIN:ZDB-MRPHLNO-120907-1	Zfish	PMID:26586223
Biological Process	GO:0001570	vasculogenesis	ITGB8	IMP		Human	PMID:12050137

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern