Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itpr1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITPR1
- Mouse genes Itpr1
- Rat genes Itpr1
- Zfish genes itpr1a,itpr1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itpr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019855	calcium channel inhibitor activity	ITPR1	IDA		Human	PMID:16793548
Molecular Function	GO:0015278	calcium-release channel activity	Itpr1	IDA		Mouse	MGI:MGI:4944154\|PMID:20813840
Molecular Function	GO:0042802	identical protein binding	Itpr1	IPI	UniProtKB:P29994-1	Rat	PMID:21827954\|RGD:13432241
Molecular Function	GO:0042802	identical protein binding	Itpr1	IPI	RGD:2933	Rat	PMID:23479737\|RGD:13793385
Molecular Function	GO:0042802	identical protein binding	Itpr1	IPI	UniProtKB:P29994-1	Rat	PMID:26458101\|RGD:13432250
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	Itpr1	IMP		Mouse	PMID:11117745
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	Itpr1	EXP		Mouse	PMID:11117745
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	Itpr1	IDA		Mouse	PMID:11117745
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IDA		Mouse	MGI:MGI:4944154\|PMID:20813840
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IDA		Mouse	PMID:2554142
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IDA		Mouse	PMID:17327232
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IDA		Rat	PMID:15533917\|RGD:7175271
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr1	IDA		Rat	PMID:19036964\|RGD:6480876
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr1	IDA		Mouse	MGI:MGI:4944154\|PMID:20813840
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr1	IDA		Mouse	PMID:8663526
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr1	IDA		Mouse	PMID:17327232
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:O43865	Human	PMID:16793548
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:O43865	Human	PMID:19220705
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:Q96HN2	Human	PMID:19220705
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:Q8N5K1	Human	PMID:20010695
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:Q15011	Human	PMID:22045699
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:Q9UMX3	Human	PMID:23884412
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:O43865	Human	PMID:27995898
Molecular Function	GO:0005515	protein binding	ITPR1	IPI	UniProtKB:Q9HD36	Human	PMID:27995898
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P70227	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q9CPV7	Mouse	MGI:MGI:5609483\|PMID:25368151
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P61264	Mouse	MGI:MGI:5796262\|PMID:21424589
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q80SW1	Mouse	MGI:MGI:5634882\|PMID:23542070
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q9D1Q6	Mouse	MGI:MGI:3529386\|PMID:15652484
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:O35425\|UniProtKB:O35425\|UniProtKB:Q8BFZ9	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:O35425	Mouse	MGI:MGI:5790897\|PMID:27053113
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:O35157\|UniProtKB:Q6PIE5\|UniProtKB:Q8VDN2	Mouse	MGI:MGI:3610760\|PMID:16292983
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P10415	Mouse	MGI:MGI:6093410\|PMID:19706527
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:32675284
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:P28651	Mouse	PMID:12611586
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q91UZ1	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:P97772	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q9Z2H5	Mouse	PMID:12444087
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q9WUX5	Mouse	PMID:15483626
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q61625	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q9Z2Y3	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q9R244	Mouse	PMID:10051594
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q61056	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:Q9QUQ5	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:P10417	Mouse	PMID:15613488
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	PR:P63328	Mouse	PMID:12617961
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:71087	Rat	PMID:12676536\|RGD:7175275
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:733700	Rat	PMID:12676536\|RGD:7175275
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:68327	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:68337	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:71087	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P42858	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P51111	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P54256-1	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P54256-2	Rat	PMID:12873381\|RGD:6482800
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:620833	Rat	PMID:15911880\|RGD:1582340
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:621595	Rat	PMID:16103111\|RGD:1599730
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	RGD:1606333	Rat	PMID:19036964\|RGD:6480876
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:P61265	Rat	PMID:21424589\|RGD:11535091
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q9ESS9	Rat	PMID:22045699\|RGD:10047316
Molecular Function	GO:0005515	protein binding	Itpr1	IPI	UniProtKB:Q3U182	Rat	PMID:22495310\|RGD:13432287
Molecular Function	GO:0019904	protein domain specific binding	Itpr1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:32675284
Molecular Function	GO:0019903	protein phosphatase binding	Itpr1	IDA		Rat	PMID:15212990\|RGD:6482804
Molecular Function	GO:0044877	protein-containing complex binding	Itpr1	IDA		Rat	PMID:15212990\|RGD:6482804
Molecular Function	GO:0044325	transmembrane transporter binding	Itpr1	IPI	RGD:1310786	Rat	PMID:23982204\|RGD:14696826
Cellular Component	GO:0005955	calcineurin complex	Itpr1	IDA		Mouse	PMID:12617961
Cellular Component	GO:0005737	cytoplasm	Itpr1	IDA		Mouse	PMID:9858485
Cellular Component	GO:0005737	cytoplasm	Itpr1	IDA		Rat	PMID:12615969\|RGD:7175278
Cellular Component	GO:0030425	dendrite	Itpr1	IDA		Rat	PMID:17471556\|RGD:6482792
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr1	IDA		Mouse	MGI:MGI:5553206\|PMID:24374158
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr1	IDA		Mouse	MGI:MGI:5609483\|PMID:25368151
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr1	IDA		Mouse	PMID:15613488
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr1	IDA		Rat	PMID:15533917\|RGD:7175271
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr1	IDA		Rat	PMID:15911880\|RGD:1582340
Cellular Component	GO:0098982	GABA-ergic synapse	Itpr1	IDA		Rat	PMID:1311032\|RGD:13702190
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Itpr1	IDA		Rat	PMID:21859719\|RGD:6480675
Cellular Component	GO:0016020	membrane	ITPR1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Itpr1	IDA		Rat	PMID:1311032\|RGD:13702190
Cellular Component	GO:0045121	membrane raft	Itpr1	IDA		Rat	PMID:15911880\|RGD:1582340
Cellular Component	GO:0043025	neuronal cell body	Itpr1	IDA		Rat	PMID:17471556\|RGD:6482792
Cellular Component	GO:0005635	nuclear envelope	Itpr1	IDA		Mouse	PMID:16014380
Cellular Component	GO:0005635	nuclear envelope	Itpr1	IDA		Rat	PMID:16014380\|RGD:7175269
Cellular Component	GO:0005637	nuclear inner membrane	Itpr1	IDA		Mouse	PMID:16014380
Cellular Component	GO:0005730	nucleolus	Itpr1	IDA		Mouse	PMID:16014380
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Itpr1	IDA		Rat	PMID:12615969\|RGD:7175278
Cellular Component	GO:0005886	plasma membrane	Itpr1	IDA		Rat	PMID:15911880\|RGD:1582340
Cellular Component	GO:0031088	platelet dense granule membrane	ITPR1	IDA		Human	PMID:10828023
Cellular Component	GO:0031094	platelet dense tubular network	ITPR1	IDA		Human	PMID:10828023
Cellular Component	GO:0098794	postsynapse	Itpr1	IDA		Rat	PMID:1311032\|RGD:13702190
Cellular Component	GO:0014069	postsynaptic density	Itpr1	IDA		Mouse	PMID:15579147
Cellular Component	GO:0014069	postsynaptic density	Itpr1	IDA		Rat	PMID:1338970\|RGD:1582341
Cellular Component	GO:0098793	presynapse	Itpr1	IDA		Rat	PMID:1311032\|RGD:13702190
Cellular Component	GO:0032991	protein-containing complex	Itpr1	IPI	PR:Q9QUQ5	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Itpr1	IPI	PR:P49817	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Itpr1	IPI	PR:Q61056	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Itpr1	IDA		Rat	PMID:12676536\|RGD:7175275
Cellular Component	GO:0016529	sarcoplasmic reticulum	Itpr1	IDA		Mouse	PMID:16014380
Cellular Component	GO:0016529	sarcoplasmic reticulum	Itpr1	IDA		Rat	PMID:16014380\|RGD:7175269
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Itpr1	IDA		Mouse	PMID:11117745
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Itpr1	IMP		Mouse	PMID:11117745
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Itpr1	EXP		Mouse	PMID:11117745
Cellular Component	GO:0030667	secretory granule membrane	Itpr1	IDA		Rat	PMID:15911880\|RGD:1582340
Cellular Component	GO:0030868	smooth endoplasmic reticulum membrane	Itpr1	IDA		Rat	PMID:1311032\|RGD:13702190
Cellular Component	GO:0045202	synapse	Itpr1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:32675284
Cellular Component	GO:0097060	synaptic membrane	Itpr1	IDA		Rat	PMID:12676536\|RGD:7175275
Biological Process	GO:0036302	atrioventricular canal development	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-210329-5	Zfish	PMID:32859249
Biological Process	GO:0036302	atrioventricular canal development	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-210329-2	Zfish	PMID:32859249
Biological Process	GO:0006816	calcium ion transport	Itpr1	IDA		Mouse	PMID:16014380
Biological Process	GO:0019722	calcium-mediated signaling	Itpr1	IDA		Mouse	MGI:MGI:6202152\|PMID:11117745
Biological Process	GO:0000902	cell morphogenesis	Itpr1	IMP		Mouse	PMID:32675284
Biological Process	GO:0071320	cellular response to cAMP	Itpr1	IDA		Rat	PMID:20189985\|RGD:7242277
Biological Process	GO:0071456	cellular response to hypoxia	Itpr1	IEP		Rat	PMID:17285299\|RGD:6482794
Biological Process	GO:1904888	cranial skeletal system development	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-211206-1	Zfish	PMID:33747042
Biological Process	GO:1904888	cranial skeletal system development	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-211206-2	Zfish	PMID:33747042
Biological Process	GO:0016358	dendrite development	Itpr1	IEP		Rat	PMID:19236309\|RGD:13793388
Biological Process	GO:0061371	determination of heart left/right asymmetry	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-210329-5	Zfish	PMID:32859249
Biological Process	GO:0061371	determination of heart left/right asymmetry	itpr1b	IMP	ZFIN:ZDB-MRPHLNO-210329-2	Zfish	PMID:32859249
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Itpr1	IGI	MGI:MGI:1097161	Mouse	PMID:15613488
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Itpr1	IGI	MGI:MGI:99702	Mouse	PMID:15613488
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Itpr1	IGI	MGI:MGI:88138	Mouse	PMID:15613488
Biological Process	GO:0042045	epithelial fluid transport	Itpr1	IDA		Mouse	MGI:MGI:5634882\|PMID:23542070
Biological Process	GO:0048016	inositol phosphate-mediated signaling	Itpr1	IDA		Mouse	MGI:MGI:6202152\|PMID:11117745
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Itpr1	IMP		Mouse	MGI:MGI:4366390\|PMID:19752026
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Itpr1	IMP		Mouse	PMID:31664108
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Itpr1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Itpr1	IMP		Mouse	PMID:26075576
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Itpr1	IMP		Mouse	PMID:31664108
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Itpr1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Itpr1	IMP		Mouse	PMID:26075576
Biological Process	GO:0097421	liver regeneration	Itpr1	IMP		Rat	PMID:24814243\|RGD:13793384
Biological Process	GO:0050849	negative regulation of calcium-mediated signaling	ITPR1	IDA		Human	PMID:16793548
Biological Process	GO:1901215	negative regulation of neuron death	Itpr1	IMP		Rat	PMID:20434434\|RGD:6480688
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Itpr1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Itpr1	IMP		Mouse	PMID:31664108
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Itpr1	IMP		Mouse	PMID:26075576
Biological Process	GO:0043065	positive regulation of apoptotic process	Itpr1	IMP		Rat	PMID:28072885\|RGD:13793382
Biological Process	GO:0051928	positive regulation of calcium ion transport	Itpr1	IDA		Rat	PMID:19036964\|RGD:6480876
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itpr1	IMP		Rat	PMID:15911880\|RGD:1582340
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itpr1	IMP		Rat	PMID:24814243\|RGD:13793384
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Itpr1	IMP		Rat	PMID:24814243\|RGD:13793384
Biological Process	GO:0032024	positive regulation of insulin secretion	Itpr1	IMP		Mouse	PMID:31664108
Biological Process	GO:0032024	positive regulation of insulin secretion	Itpr1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:0032024	positive regulation of insulin secretion	Itpr1	IMP		Mouse	PMID:26075576
Biological Process	GO:0010976	positive regulation of neuron projection development	Itpr1	IMP		Rat	PMID:21211516\|RGD:13793387
Biological Process	GO:0009791	post-embryonic development	Itpr1	IMP	MGI:MGI:1856981	Mouse	PMID:17590087
Biological Process	GO:0009791	post-embryonic development	Itpr1	IMP	MGI:MGI:3715928	Mouse	PMID:17590087
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	Itpr1	IDA		Mouse	MGI:MGI:6202152\|PMID:11117745
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Itpr1	IMP		Mouse	MGI:MGI:4366390\|PMID:19752026
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Itpr1	IDA		Mouse	MGI:MGI:6202152\|PMID:11117745
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Itpr1	IMP		Rat	PMID:16223735\|RGD:8554324
Biological Process	GO:0001666	response to hypoxia	ITPR1	IDA		Human	PMID:19120137
Biological Process	GO:0001666	response to hypoxia	Itpr1	IDA		Mouse	MGI:MGI:3836482\|PMID:19120137
Biological Process	GO:0050882	voluntary musculoskeletal movement	Itpr1	IMP	MGI:MGI:1856981	Mouse	PMID:17590087
Biological Process	GO:0050882	voluntary musculoskeletal movement	Itpr1	IMP	MGI:MGI:3715928	Mouse	PMID:17590087

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.