Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITPR2
  • Mouse genes Itpr2
  • Rat genes Itpr2
  • Zfish genes itpr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itpr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Itpr2	IDA		Rat	PMID:10969001|RGD:7175277
Molecular Function	GO:0015278	calcium-release channel activity	Itpr2	IDA		Mouse	PMID:8063813
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Itpr2	IDA		Rat	PMID:10969001|RGD:7175277
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Itpr2	IDA		Rat	PMID:17081354|RGD:7175267
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr2	IDA		Mouse	PMID:17327232
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr2	IDA		Mouse	PMID:8063813
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr2	IDA		Rat	PMID:10969001|RGD:7175277
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr2	IDA		Rat	PMID:15533917|RGD:7175271
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr2	IMP		Rat	PMID:23166348|RGD:12790654
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr2	IDA		Mouse	PMID:17327232
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr2	IDA		Mouse	PMID:8063813
Molecular Function	GO:0005515	protein binding	Itpr2	IPI	UniProtKB:P61264	Mouse	MGI:MGI:5796262|PMID:21424589
Molecular Function	GO:0005515	protein binding	Itpr2	IPI	UniProtKB:O35425	Rat	PMID:23884412|RGD:11535097
Molecular Function	GO:0097110	scaffold protein binding	ITPR2	IPI	UniProtKB:Q8NDB2	Human	PMID:11782428
Molecular Function	GO:0044325	transmembrane transporter binding	ITPR2	IPI	UniProtKB:P48995	Human	PMID:18068335
Cellular Component	GO:0030424	axon	Itpr2	IDA		Rat	PMID:17091480|RGD:2289692
Cellular Component	GO:0005938	cell cortex	Itpr2	IDA		Mouse	PMID:9858485
Cellular Component	GO:0005737	cytoplasm	Itpr2	IDA		Mouse	PMID:9858485
Cellular Component	GO:0005737	cytoplasm	Itpr2	IDA		Rat	PMID:17091480|RGD:2289692
Cellular Component	GO:0005783	endoplasmic reticulum	ITPR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr2	IDA		Rat	PMID:17081354|RGD:7175267
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr2	IDA		Rat	PMID:17091480|RGD:2289692
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr2	IDA		Rat	PMID:10969001|RGD:7175277
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr2	IDA		Rat	PMID:15533917|RGD:7175271
Cellular Component	GO:0016020	membrane	ITPR2	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Itpr2	IDA		Rat	PMID:17091480|RGD:2289692
Cellular Component	GO:0005654	nucleoplasm	ITPR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ITPR2	IDA		Human	PMID:10828023
Cellular Component	GO:0043235	receptor complex	ITPR2	IDA		Human	PMID:23382219
Cellular Component	GO:0016529	sarcoplasmic reticulum	Itpr2	IDA		Mouse	PMID:16014380
Cellular Component	GO:0016529	sarcoplasmic reticulum	Itpr2	IDA		Rat	PMID:16014380|RGD:7175269
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	ITPR2	IMP		Human	PMID:10828023
Biological Process	GO:0006816	calcium ion transport	Itpr2	IDA		Mouse	PMID:8063813
Biological Process	GO:0071320	cellular response to cAMP	Itpr2	IDA		Mouse	MGI:MGI:4834733|PMID:20189985
Biological Process	GO:0071361	cellular response to ethanol	Itpr2	IMP	MGI:MGI:3604623	Mouse	PMID:21436055
Biological Process	GO:0071456	cellular response to hypoxia	Itpr2	IEP		Rat	PMID:17285299|RGD:6482794
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Itpr2	IMP		Rat	PMID:23166348|RGD:12790654
Biological Process	GO:0001666	response to hypoxia	ITPR2	IDA		Human	PMID:19120137

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern