Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itpr3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITPR3
- Mouse genes Itpr3
- Rat genes Itpr3
- Zfish genes itpr3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itpr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Itpr3	IDA		Rat	PMID:17320950\|RGD:7175265
Molecular Function	GO:0005509	calcium ion binding	Itpr3	IDA		Rat	PMID:17373911\|RGD:7175268
Molecular Function	GO:0015278	calcium-release channel activity	Itpr3	IDA		Mouse	MGI:MGI:4944154\|PMID:20813840
Molecular Function	GO:0042802	identical protein binding	Itpr3	IPI	RGD:2934	Rat	PMID:10694253\|RGD:2290285
Molecular Function	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding	Itpr3	IDA		Rat	PMID:8388391\|RGD:729040
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	ITPR3	IDA		Human	PMID:8288584
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Itpr3	IDA		Rat	PMID:17320950\|RGD:7175265
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Itpr3	IDA		Rat	PMID:17373911\|RGD:7175268
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ITPR3	IDA		Human	PMID:10828023
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Mouse	MGI:MGI:4944154\|PMID:20813840
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Mouse	PMID:17327232
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Mouse	PMID:15890645
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Rat	PMID:10694253\|RGD:2290285
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Rat	PMID:15533917\|RGD:7175271
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Rat	PMID:17320950\|RGD:7175265
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Itpr3	IDA		Rat	PMID:17373911\|RGD:7175268
Molecular Function	GO:0000822	inositol hexakisphosphate binding	Itpr3	IDA		Rat	PMID:8388391\|RGD:729040
Molecular Function	GO:0035091	phosphatidylinositol binding	Itpr3	IDA		Mouse	PMID:17327232
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q13507	Human	PMID:10611319
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:P48995	Human	PMID:19052258
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q03135	Human	PMID:19052258
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q9HC24	Human	PMID:19553469
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q12797-2	Human	PMID:21062895
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q969S6	Human	PMID:25996873
Molecular Function	GO:0005515	protein binding	ITPR3	IPI	UniProtKB:Q92560	Human	PMID:28614305
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:Q60664	Mouse	MGI:MGI:5526934\|PMID:20071408
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:P31750\|UniProtKB:Q60953	Mouse	MGI:MGI:4849347\|PMID:21030605
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:P61264	Mouse	MGI:MGI:5796262\|PMID:21424589
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:O35425	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:P11881	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	PR:A2A863	Mouse	PMID:29315582
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	PR:G5E829	Mouse	PMID:16352659
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:P61265	Rat	PMID:21424589\|RGD:11535091
Molecular Function	GO:0005515	protein binding	Itpr3	IPI	UniProtKB:O35425	Rat	PMID:23884412\|RGD:11535097
Molecular Function	GO:0044877	protein-containing complex binding	Itpr3	IDA		Rat	PMID:10694253\|RGD:2290285
Cellular Component	GO:0045177	apical part of cell	Itpr3	IDA		Rat	PMID:8288584\|RGD:8553539
Cellular Component	GO:0005903	brush border	Itpr3	IDA		Rat	PMID:8288584\|RGD:8553539
Cellular Component	GO:0005737	cytoplasm	Itpr3	IDA		Mouse	PMID:16014380
Cellular Component	GO:0005737	cytoplasm	Itpr3	IDA		Rat	PMID:12615969\|RGD:7175278
Cellular Component	GO:0005737	cytoplasm	Itpr3	IDA		Rat	PMID:15537642\|RGD:7175270
Cellular Component	GO:0005737	cytoplasm	Itpr3	IDA		Rat	PMID:17091480\|RGD:2289692
Cellular Component	GO:0030425	dendrite	Itpr3	IDA		Rat	PMID:17471556\|RGD:6482792
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr3	IDA		Rat	PMID:19116207\|RGD:7242196
Cellular Component	GO:0005783	endoplasmic reticulum	Itpr3	IDA		Rat	PMID:8388391\|RGD:729040
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ITPR3	IDA		Human	PMID:21062895
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr3	IDA		Mouse	MGI:MGI:4849347\|PMID:21030605
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr3	IDA		Rat	PMID:10096607\|RGD:13702443
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr3	IDA		Rat	PMID:15533917\|RGD:7175271
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Itpr3	IDA		Rat	PMID:15537642\|RGD:7175270
Cellular Component	GO:0016020	membrane	ITPR3	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Itpr3	IDA		Rat	PMID:17091480\|RGD:2289692
Cellular Component	GO:0043025	neuronal cell body	Itpr3	IDA		Rat	PMID:17091480\|RGD:2289692
Cellular Component	GO:0005635	nuclear envelope	Itpr3	IDA		Rat	PMID:15537642\|RGD:7175270
Cellular Component	GO:0005640	nuclear outer membrane	Itpr3	IDA		Rat	PMID:8388391\|RGD:729040
Cellular Component	GO:0005730	nucleolus	Itpr3	IDA		Mouse	PMID:16014380
Cellular Component	GO:0005654	nucleoplasm	Itpr3	IDA		Mouse	PMID:16014380
Cellular Component	GO:0005634	nucleus	Itpr3	IDA		Mouse	PMID:16014380
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Itpr3	IDA		Rat	PMID:21550988\|RGD:7247592
Cellular Component	GO:0005886	plasma membrane	ITPR3	IDA		Human	PMID:10828023
Cellular Component	GO:0005886	plasma membrane	ITPR3	IDA		Human	PMID:21062895
Cellular Component	GO:0098793	presynapse	Itpr3	IDA		Rat	PMID:10096607\|RGD:13702443
Cellular Component	GO:0043235	receptor complex	ITPR3	IDA		Human	PMID:23382219
Biological Process	GO:0055074	calcium ion homeostasis	ITPR3	IMP		Human	PMID:32949214
Biological Process	GO:0006816	calcium ion transport	Itpr3	IDA		Mouse	PMID:15890645
Biological Process	GO:0006816	calcium ion transport	Itpr3	IDA		Mouse	PMID:16014380
Biological Process	GO:0071320	cellular response to cAMP	Itpr3	IDA		Rat	PMID:20189985\|RGD:7242277
Biological Process	GO:0048706	embryonic skeletal system development	itpr3	IMP	ZFIN:ZDB-GENO-180504-4	Zfish	PMID:28835471
Biological Process	GO:0048706	embryonic skeletal system development	itpr3	IMP	ZFIN:ZDB-GENO-180504-5	Zfish	PMID:28835471
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Itpr3	IDA		Rat	PMID:11788349\|RGD:619539
Biological Process	GO:0060291	long-term synaptic potentiation	Itpr3	IMP	MGI:MGI:1857070	Mouse	PMID:18417102
Biological Process	GO:0007613	memory	Itpr3	IMP	MGI:MGI:1857070	Mouse	PMID:18417102
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itpr3	IDA		Rat	PMID:11788349\|RGD:619539
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itpr3	IDA		Rat	PMID:17320950\|RGD:7175265
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Itpr3	IDA		Rat	PMID:17373911\|RGD:7175268
Biological Process	GO:0051592	response to calcium ion	ITPR3	IDA		Human	PMID:19052258
Biological Process	GO:0050913	sensory perception of bitter taste	Itpr3	IMP	MGI:MGI:3604625	Mouse	PMID:17925404
Biological Process	GO:0050916	sensory perception of sweet taste	Itpr3	IMP	MGI:MGI:3604625	Mouse	PMID:17925404
Biological Process	GO:0050917	sensory perception of umami taste	Itpr3	IMP	MGI:MGI:3604625	Mouse	PMID:17925404
Biological Process	GO:0001501	skeletal system development	itpr3	IMP	ZFIN:ZDB-GENO-180503-10	Zfish	PMID:28835471

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.