Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ITSN1
  • Mouse genes Itsn1
  • Rat genes Itsn1
  • Zfish genes itsn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itsn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019209	kinase activator activity	Itsn1	IDA		Mouse	PMID:17875942
Molecular Function	GO:0060090	molecular adaptor activity	ITSN1	IDA		Human	PMID:20946875
Molecular Function	GO:0070064	proline-rich region binding	ITSN1	IPI	UniProtKB:Q9BQI5	Human	PMID:20946875
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P42566	Human	PMID:10064583
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P60953-1	Human	PMID:12006984
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:Q9NRI5	Human	PMID:12812986
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P50570	Human	PMID:16696976
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P22681	Human	PMID:16914641
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P22681	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P63010	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:Q3UQN2	Human	PMID:20448150
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:Q96D71	Human	PMID:20946875
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P50570	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:O94868	Human	PMID:29887380
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P42566	Human	PMID:32203420
Molecular Function	GO:0005515	protein binding	ITSN1	IPI	UniProtKB:P63010	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	UniProtKB:Q8K382	Mouse	MGI:MGI:3694831|PMID:17182770
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	UniProtKB:A6X8Z5	Mouse	MGI:MGI:5294523|PMID:21349274
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	UniProtKB:Q6P549	Mouse	MGI:MGI:5512958|PMID:18692052
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	PR:A6X8Z5	Mouse	PMID:11744688
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	MGI:MGI:2685045	Mouse	PMID:17875942
Molecular Function	GO:0005515	protein binding	Itsn1	IPI	RGD:3728|RGD:620221|RGD:71096	Rat	PMID:10373452|RGD:69862
Cellular Component	GO:0097440	apical dendrite	Itsn1	IDA		Rat	PMID:12548702|RGD:13461862
Cellular Component	GO:0044305	calyx of Held	Itsn1	IDA		Mouse	PMID:23633571
Cellular Component	GO:0005905	clathrin-coated pit	ITSN1	IDA		Human	PMID:29887380
Cellular Component	GO:0005905	clathrin-coated pit	ITSN1	IDA		Human	PMID:20946875
Cellular Component	GO:0005905	clathrin-coated pit	Itsn1	IDA		Mouse	PMID:26437238
Cellular Component	GO:0005905	clathrin-coated pit	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Cellular Component	GO:0043197	dendritic spine	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Cellular Component	GO:0030139	endocytic vesicle	Itsn1	IDA		Mouse	PMID:17875942
Cellular Component	GO:0098978	glutamatergic synapse	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Cellular Component	GO:0098978	glutamatergic synapse	Itsn1	IMP		Rat	PMID:19258322|RGD:13461864
Cellular Component	GO:0097708	intracellular vesicle	Itsn1	IDA		Rat	PMID:12548702|RGD:13461862
Cellular Component	GO:0030027	lamellipodium	Itsn1	IDA		Mouse	PMID:11744688
Cellular Component	GO:0043025	neuronal cell body	Itsn1	IDA		Rat	PMID:12548702|RGD:13461862
Cellular Component	GO:0005886	plasma membrane	ITSN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ITSN1	IDA		Human	PMID:20946875
Cellular Component	GO:0005886	plasma membrane	Itsn1	IDA		Rat	PMID:16874303|RGD:13461861
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Cellular Component	GO:0098833	presynaptic endocytic zone	Itsn1	IDA		Mouse	PMID:23633571
Cellular Component	GO:0045202	synapse	Itsn1	IDA		Rat	PMID:10373452|RGD:69862
Cellular Component	GO:0043195	terminal bouton	Itsn1	HDA		Rat	PMID:24876496|RGD:10047219
Biological Process	GO:0007420	brain development	Itsn1	IEP		Rat	PMID:10373452|RGD:69862
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Itsn1	IMP		Mouse	PMID:17875942
Biological Process	GO:0051402	neuron apoptotic process	Itsn1	IMP		Mouse	PMID:17875942
Biological Process	GO:2001288	positive regulation of caveolin-mediated endocytosis	Itsn1	IMP		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:0060999	positive regulation of dendritic spine development	Itsn1	IMP		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Itsn1	IMP		Rat	PMID:16874303|RGD:13461861
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Itsn1	IDA		Mouse	PMID:17875942
Biological Process	GO:0008104	protein localization	ITSN1	IMP		Human	PMID:29887380
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	Itsn1	IMP		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:0099175	regulation of postsynapse organization	Itsn1	IDA		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:0099175	regulation of postsynapse organization	Itsn1	IMP		Rat	PMID:19258322|RGD:13461864
Biological Process	GO:0007264	small GTPase mediated signal transduction	Itsn1	IDA		Mouse	PMID:11744688
Biological Process	GO:0048488	synaptic vesicle endocytosis	Itsn1	IDA		Mouse	PMID:18676989
Biological Process	GO:0048488	synaptic vesicle endocytosis	Itsn1	IMP		Mouse	PMID:18676989

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern