Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IZUMO1
  • Mouse genes Izumo1
  • Rat genes Izumo1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Izumo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IZUMO1	IPI	UniProtKB:A6ND01	Human	PMID:27309808
Molecular Function	GO:0005515	protein binding	Izumo1	IPI	UniProtKB:Q9EQF4	Mouse	MGI:MGI:5896483|PMID:27416963
Molecular Function	GO:0005515	protein binding	Izumo1	IPI	UniProtKB:Q9DAG6	Mouse	MGI:MGI:6436237|PMID:31672133
Molecular Function	GO:0005515	protein binding	Izumo1	IPI	UniProtKB:Q8CF31	Mouse	MGI:MGI:7332329|PMID:35960805
Molecular Function	GO:0005515	protein binding	Izumo1	IPI	PR:D0G895	Mouse	PMID:20421979
Molecular Function	GO:0086080	protein binding involved in heterotypic cell-cell adhesion	Izumo1	IMP		Mouse	MGI:MGI:5796060|PMID:27309808
Molecular Function	GO:0042803	protein homodimerization activity	Izumo1	IDA		Mouse	MGI:MGI:4412213|PMID:19658160
Molecular Function	GO:0042803	protein homodimerization activity	Izumo1	IDA		Rat	PMID:19658160|RGD:8553965
Molecular Function	GO:0005102	signaling receptor binding	IZUMO1	IPI	UniProtKB:A6ND01	Human	PMID:24739963
Molecular Function	GO:0005102	signaling receptor binding	Izumo1	IPI	UniProtKB:Q9EQF4	Mouse	MGI:MGI:5568137|PMID:24739963
Cellular Component	GO:0002080	acrosomal membrane	Izumo1	IDA		Mouse	MGI:MGI:6144353|PMID:27624483
Cellular Component	GO:0002080	acrosomal membrane	Izumo1	IDA		Mouse	PMID:19144954
Cellular Component	GO:0002080	acrosomal membrane	Izumo1	IDA		Mouse	PMID:20375058
Cellular Component	GO:0001669	acrosomal vesicle	Izumo1	IDA		Mouse	MGI:MGI:6436237|PMID:31672133
Cellular Component	GO:0001669	acrosomal vesicle	Izumo1	IDA		Mouse	PMID:32529245
Cellular Component	GO:0001669	acrosomal vesicle	Izumo1	IDA		Mouse	PMID:20421979
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Izumo1	IDA		Mouse	MGI:MGI:7332329|PMID:35960805
Cellular Component	GO:0016020	membrane	IZUMO1	IDA		Human	PMID:15759005
Cellular Component	GO:0016020	membrane	Izumo1	IDA		Mouse	MGI:MGI:3575846|PMID:15759005
Cellular Component	GO:0005886	plasma membrane	Izumo1	IMP		Mouse	MGI:MGI:5796060|PMID:27309808
Cellular Component	GO:0005886	plasma membrane	Izumo1	IDA		Mouse	MGI:MGI:6144353|PMID:27624483
Cellular Component	GO:0098635	protein complex involved in cell-cell adhesion	Izumo1	IDA		Mouse	MGI:MGI:6436237|PMID:31672133
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	IZUMO1	IDA		Human	PMID:15759005
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Izumo1	IMP		Mouse	MGI:MGI:7332329|PMID:35960805
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Izumo1	IDA		Mouse	MGI:MGI:3575846|PMID:15759005
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Izumo1	IMP		Mouse	MGI:MGI:5568137|PMID:24739963
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Izumo1	IMP		Mouse	MGI:MGI:6436237|PMID:31672133
Biological Process	GO:0034113	heterotypic cell-cell adhesion	Izumo1	IMP		Mouse	MGI:MGI:5796060|PMID:27309808
Biological Process	GO:0007338	single fertilization	Izumo1	IMP		Mouse	MGI:MGI:5568137|PMID:24739963
Biological Process	GO:0035036	sperm-egg recognition	Izumo1	IMP		Mouse	MGI:MGI:7332329|PMID:35960805
Biological Process	GO:0035036	sperm-egg recognition	Izumo1	IMP		Mouse	MGI:MGI:5568137|PMID:24739963

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern