Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAG1
  • Mouse genes Jag1
  • Rat genes Jag1
  • Zfish genes jag1a,jag1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jag1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	JAG1	EXP		Human	PMID:16427310
Molecular Function	GO:0060090	molecular adaptor activity	JAG1	IDA		Human	PMID:16427310
Molecular Function	GO:0005112	Notch binding	JAG1	IPI	UniProtKB:P46531|UniProtKB:Q9UM47	Human	PMID:11006133
Molecular Function	GO:0005112	Notch binding	Jag1	IPI	UniProtKB:O35516	Mouse	MGI:MGI:3029032|PMID:10958687
Molecular Function	GO:0005112	Notch binding	Jag1	IPI	UniProtKB:O35516|UniProtKB:Q01705|UniProtKB:Q61982	Mouse	MGI:MGI:1347427|PMID:10551863
Molecular Function	GO:0005112	Notch binding	Jag1	IPI	UniProtKB:Q01705	Rat	PMID:28089369|RGD:13210539
Molecular Function	GO:0005543	phospholipid binding	JAG1	IMP		Human	PMID:22465068
Molecular Function	GO:0005515	protein binding	JAG1	IPI	UniProtKB:P46531	Human	PMID:18660822
Molecular Function	GO:0005515	protein binding	JAG1	IPI	UniProtKB:P15529	Human	PMID:23086448
Molecular Function	GO:0005515	protein binding	JAG1	IPI	UniProtKB:P46531	Human	PMID:23086448
Molecular Function	GO:0005515	protein binding	Jag1	IPI	UniProtKB:P55002|UniProtKB:Q9QZJ6	Mouse	MGI:MGI:5693233|PMID:15788413
Molecular Function	GO:0005515	protein binding	Jag1	IPI	PR:Q80SY4	Mouse	PMID:16000382
Molecular Function	GO:0005515	protein binding	Jag1	IPI	PR:Q01705	Mouse	PMID:15574878
Molecular Function	GO:0005515	protein binding	Jag1	IPI	RGD:1311546	Rat	PMID:20145246|RGD:7242200
Molecular Function	GO:0005515	protein binding	Jag1	IPI	UniProtKB:Q03350	Rat	PMID:20472562|RGD:8553581
Molecular Function	GO:0005515	protein binding	Jag1	IPI	UniProtKB:Q07954	Rat	PMID:20472562|RGD:8553581
Molecular Function	GO:0048018	receptor ligand activity	Jag1	IDA		Rat	PMID:7697721|RGD:69863
Cellular Component	GO:0005912	adherens junction	Jag1	IDA		Mouse	MGI:MGI:5565112|PMID:24715457
Cellular Component	GO:0045177	apical part of cell	Jag1	IDA		Mouse	MGI:MGI:3576186|PMID:15821257
Cellular Component	GO:0016324	apical plasma membrane	Jag1	IDA		Mouse	MGI:MGI:5565112|PMID:24715457
Cellular Component	GO:0016020	membrane	JAG1	IMP		Human	PMID:22465068
Cellular Component	GO:0005886	plasma membrane	JAG1	IDA		Human	PMID:20437614
Cellular Component	GO:0005886	plasma membrane	JAG1	IDA		Human	PMID:32065591
Cellular Component	GO:0005886	plasma membrane	Jag1	IDA		Mouse	PMID:16495313
Cellular Component	GO:0005886	plasma membrane	Jag1	IDA		Mouse	PMID:16000382
Cellular Component	GO:0005886	plasma membrane	Jag1	IDA		Rat	PMID:15057910|RGD:1334443
Cellular Component	GO:0005886	plasma membrane	jag1a	IMP		Zfish	PMID:25416946
Biological Process	GO:0009887	animal organ morphogenesis	Jag1	IMP	MGI:MGI:1931798	Mouse	PMID:11181574
Biological Process	GO:0031100	animal organ regeneration	Jag1	IEP		Rat	PMID:15057910|RGD:1334443
Biological Process	GO:0035909	aorta morphogenesis	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0060117	auditory receptor cell development	jag1b	IMP	ZFIN:ZDB-GENO-071114-4	Zfish	PMID:17574823
Biological Process	GO:0001974	blood vessel remodeling	Jag1	IMP	MGI:MGI:1857713	Mouse	PMID:10196361
Biological Process	GO:0043010	camera-type eye development	Jag1	IMP	MGI:MGI:1857713	Mouse	PMID:10196361
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0060411	cardiac septum morphogenesis	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	jag1b	IGI	ZFIN:ZDB-GENO-100727-7	Zfish	PMID:20431122
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-100604-1	Zfish	PMID:20431122
Biological Process	GO:0061073	ciliary body morphogenesis	Jag1	IMP	MGI:MGI:3692444	Mouse	PMID:23676271
Biological Process	GO:1904888	cranial skeletal system development	jag1b	IMP	ZFIN:ZDB-GENO-100604-1	Zfish	PMID:27058748
Biological Process	GO:0072017	distal tubule development	Jag1	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0009953	dorsal/ventral pattern formation	jag1b	IMP	ZFIN:ZDB-GENO-100604-1	Zfish	PMID:20431122
Biological Process	GO:0061444	endocardial cushion cell development	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0031017	exocrine pancreas development	jag1b	IGI	ZFIN:ZDB-GENO-180614-3	Zfish	PMID:28974684
Biological Process	GO:0060325	face morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-100604-1	Zfish	PMID:20431122
Biological Process	GO:0060325	face morphogenesis	jag1b	IGI	ZFIN:ZDB-GENO-100727-7	Zfish	PMID:20431122
Biological Process	GO:0031101	fin regeneration	jag1b	IMP	ZFIN:ZDB-MRPHLNO-041207-3	Zfish	PMID:23344707
Biological Process	GO:0060218	hematopoietic stem cell differentiation	jag1a	IGI	ZFIN:ZDB-GENE-980526-375	Zfish	PMID:27499523
Biological Process	GO:0060218	hematopoietic stem cell differentiation	jag1a	IMP	ZFIN:ZDB-MRPHLNO-100809-2	Zfish	PMID:27499523
Biological Process	GO:0002085	inhibition of neuroepithelial cell differentiation	Jag1	IMP		Mouse	PMID:15064243
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Jag1	IMP	MGI:MGI:1932522,MGI:MGI:3623344	Mouse	PMID:16495313
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Jag1	IMP		Rat	PMID:10887092|RGD:1582345
Biological Process	GO:0048839	inner ear development	Jag1	IMP		Mouse	MGI:MGI:3848573|PMID:19389353
Biological Process	GO:0042472	inner ear morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-071114-4	Zfish	PMID:17574823
Biological Process	GO:0042472	inner ear morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-071114-4	Zfish	PMID:23052906
Biological Process	GO:0042472	inner ear morphogenesis	jag1b	IMP	ZFIN:ZDB-MRPHLNO-121210-1	Zfish	PMID:23052906
Biological Process	GO:0035622	intrahepatic bile duct development	jag1b	IGI	ZFIN:ZDB-GENO-180614-3	Zfish	PMID:28974684
Biological Process	GO:0001889	liver development	jag1b	IGI	ZFIN:ZDB-GENE-011128-3	Zfish	PMID:15509774
Biological Process	GO:0072070	loop of Henle development	Jag1	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	Jag1	IMP	MGI:MGI:1857713	Mouse	PMID:11861489
Biological Process	GO:0045596	negative regulation of cell differentiation	Jag1	IDA		Rat	PMID:7697721|RGD:69863
Biological Process	GO:0030336	negative regulation of cell migration	JAG1	IDA		Human	PMID:11549580
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	JAG1	IDA		Human	PMID:11549580
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	JAG1	IDA		Human	PMID:11549580
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	Jag1	IDA		Mouse	MGI:MGI:5661129|PMID:25535084
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Jag1	IDA		Mouse	PMID:15060169
Biological Process	GO:0045665	negative regulation of neuron differentiation	Jag1	IMP	MGI:MGI:4420947	Mouse	PMID:20081190
Biological Process	GO:0045665	negative regulation of neuron differentiation	Jag1	IMP		Mouse	PMID:15064243
Biological Process	GO:2000737	negative regulation of stem cell differentiation	JAG1	IMP		Human	PMID:19682396
Biological Process	GO:0072006	nephron development	Jag1	IMP		Mouse	MGI:MGI:5498584|PMID:23806616
Biological Process	GO:0061101	neuroendocrine cell differentiation	Jag1	IMP		Mouse	PMID:15064243
Biological Process	GO:0030182	neuron differentiation	Jag1	IMP	MGI:MGI:4420947	Mouse	PMID:20081190
Biological Process	GO:0097150	neuronal stem cell population maintenance	JAG1	IEP		Human	PMID:19682396
Biological Process	GO:0038061	NIK/NF-kappaB signaling	jag1a	IMP		Zfish	PMID:25416946
Biological Process	GO:0061314	Notch signaling involved in heart development	JAG1	IMP		Human	PMID:20437614
Biological Process	GO:0061314	Notch signaling involved in heart development	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0007219	Notch signaling pathway	JAG1	IMP		Human	PMID:19682396
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Mouse	PMID:24667410
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Mouse	PMID:25446530
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Mouse	PMID:15845452
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Mouse	PMID:15574878
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IGI	MGI:MGI:96522	Mouse	PMID:25406395
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IMP		Rat	PMID:15057910|RGD:1334443
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Rat	PMID:18593716|RGD:11071830
Biological Process	GO:0007219	Notch signaling pathway	Jag1	IDA		Rat	PMID:7697721|RGD:69863
Biological Process	GO:0032474	otolith morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-071114-4	Zfish	PMID:17574823
Biological Process	GO:0031016	pancreas development	jag1b	IGI	ZFIN:ZDB-MRPHLNO-041207-2,ZFIN:ZDB-MRPHLNO-041207-3	Zfish	PMID:15963491
Biological Process	GO:0072015	podocyte development	Jag1	IMP		Mouse	MGI:MGI:5498584|PMID:23806616
Biological Process	GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	Jag1	IGI	UniProtKB:Q07008	Rat	PMID:20951801|RGD:13601997
Biological Process	GO:0010628	positive regulation of gene expression	Jag1	IGI	UniProtKB:Q07008	Rat	PMID:20951801|RGD:13601997
Biological Process	GO:1902038	positive regulation of hematopoietic stem cell differentiation	jag1a	IMP	ZFIN:ZDB-MRPHLNO-100809-2	Zfish	PMID:25416946
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	Jag1	IDA		Mouse	PMID:15845452
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Jag1	IDA		Mouse	MGI:MGI:3029032|PMID:10958687
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Jag1	IDA		Mouse	PMID:23980096
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	JAG1	IMP		Human	PMID:20437614
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Jag1	IMP		Mouse	MGI:MGI:4359139|PMID:19509466
Biological Process	GO:0061156	pulmonary artery morphogenesis	JAG1	IMP		Human	PMID:9207787
Biological Process	GO:0003184	pulmonary valve morphogenesis	JAG1	IMP		Human	PMID:20437614
Biological Process	GO:0003184	pulmonary valve morphogenesis	JAG1	IMP		Human	PMID:9207787
Biological Process	GO:0042127	regulation of cell population proliferation	Jag1	IMP		Rat	PMID:15057910|RGD:1334443
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Jag1	IGI	MGI:MGI:96522	Mouse	PMID:25406395
Biological Process	GO:2000241	regulation of reproductive process	Jag1	IGI	MGI:MGI:96522	Mouse	PMID:25406395
Biological Process	GO:0032495	response to muramyl dipeptide	Jag1	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0060872	semicircular canal development	jag1b	IMP	ZFIN:ZDB-GENO-150508-2	Zfish	PMID:25617438
Biological Process	GO:0048752	semicircular canal morphogenesis	jag1b	IMP	ZFIN:ZDB-GENO-071114-4	Zfish	PMID:17574823
Biological Process	GO:0002456	T cell mediated immunity	JAG1	IMP		Human	PMID:23086448
Biological Process	GO:0030878	thyroid gland development	jag1a	IMP	ZFIN:ZDB-MRPHLNO-121129-2	Zfish	PMID:23008514
Biological Process	GO:0030878	thyroid gland development	jag1a	IGI	ZFIN:ZDB-GENE-011128-4	Zfish	PMID:26760175
Biological Process	GO:0030878	thyroid gland development	jag1b	IGI	ZFIN:ZDB-GENE-011128-2	Zfish	PMID:26760175
Biological Process	GO:0030878	thyroid gland development	jag1b	IMP	ZFIN:ZDB-MRPHLNO-070206-6	Zfish	PMID:23008514
Biological Process	GO:0042060	wound healing	Jag1	IEP		Rat	PMID:11549580|RGD:13506277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern