Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAG2
  • Mouse genes Jag2
  • Rat genes Jag2
  • Zfish genes jag2a,jag2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jag2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008083	growth factor activity	JAG2	IDA		Human	PMID:10383933
Molecular Function	GO:0005112	Notch binding	JAG2	IPI	UniProtKB:Q01705	Human	PMID:9315665
Molecular Function	GO:0005112	Notch binding	Jag2	IPI	UniProtKB:O35516	Mouse	MGI:MGI:3029032|PMID:10958687
Molecular Function	GO:0005515	protein binding	JAG2	IPI	UniProtKB:Q5VTD9	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	Jag2	IPI	UniProtKB:P55002|UniProtKB:Q9QZJ6	Mouse	MGI:MGI:5693233|PMID:15788413
Molecular Function	GO:0005515	protein binding	Jag2	IPI	UniProtKB:O35516	Mouse	MGI:MGI:3691907|PMID:12496659
Cellular Component	GO:0016020	membrane	Jag2	IDA		Mouse	PMID:15886206
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Jag2	IDA		Rat	PMID:11700865|RGD:2302248
Cellular Component	GO:0005886	plasma membrane	Jag2	IDA		Mouse	MGI:MGI:1861322|PMID:10910909
Biological Process	GO:0009912	auditory receptor cell fate commitment	Jag2	IMP		Mouse	MGI:MGI:1332721|PMID:10080181
Biological Process	GO:0007420	brain development	Jag2	IEP		Rat	PMID:14743446|RGD:1304491
Biological Process	GO:0030154	cell differentiation	JAG2	IDA		Human	PMID:11700865
Biological Process	GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:16607638
Biological Process	GO:0031017	exocrine pancreas development	jag2b	IGI	ZFIN:ZDB-GENO-180614-3	Zfish	PMID:28974684
Biological Process	GO:0042492	gamma-delta T cell differentiation	Jag2	IMP		Mouse	MGI:MGI:1342169|PMID:10383933
Biological Process	GO:0001701	in utero embryonic development	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:9531541
Biological Process	GO:0035622	intrahepatic bile duct development	jag2b	IGI	ZFIN:ZDB-GENO-180614-3	Zfish	PMID:28974684
Biological Process	GO:0001889	liver development	jag2b	IGI	ZFIN:ZDB-GENE-011128-4	Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	jag2b	IGI	ZFIN:ZDB-GENE-000329-5	Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	jag2b	IMP		Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	jag2b	IGI	ZFIN:ZDB-GENE-000329-4	Zfish	PMID:15509774
Biological Process	GO:0008584	male gonad development	Jag2	IEP		Rat	PMID:15292098|RGD:2302247
Biological Process	GO:0016331	morphogenesis of embryonic epithelium	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:16607638
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:15721140
Biological Process	GO:0031016	pancreas development	jag2b	IGI	ZFIN:ZDB-MRPHLNO-041207-2,ZFIN:ZDB-MRPHLNO-041207-3	Zfish	PMID:15963491
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Jag2	IDA		Mouse	MGI:MGI:3029032|PMID:10958687
Biological Process	GO:0048793	pronephros development	jag2b	IMP	ZFIN:ZDB-MRPHLNO-070611-2	Zfish	PMID:17287248
Biological Process	GO:0030155	regulation of cell adhesion	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:16607638
Biological Process	GO:0042127	regulation of cell population proliferation	JAG2	IDA		Human	PMID:10383933
Biological Process	GO:0003016	respiratory system process	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:9531541
Biological Process	GO:0001666	response to hypoxia	Jag2	IEP		Rat	PMID:18344904|RGD:2302246
Biological Process	GO:0001501	skeletal system development	Jag2	IMP	MGI:MGI:2657215	Mouse	PMID:15721140
Biological Process	GO:0007283	spermatogenesis	JAG2	IEP		Human	PMID:11700865
Biological Process	GO:0007283	spermatogenesis	Jag2	IMP		Rat	PMID:11700865|RGD:2302248
Biological Process	GO:0021522	spinal cord motor neuron differentiation	jag2b	IMP	ZFIN:ZDB-MRPHLNO-070615-2	Zfish	PMID:17389390
Biological Process	GO:0030217	T cell differentiation	JAG2	IDA		Human	PMID:10383933
Biological Process	GO:0045061	thymic T cell selection	JAG2	IDA		Human	PMID:10383933
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	jag2b	IMP	ZFIN:ZDB-MRPHLNO-070615-3	Zfish	PMID:17389390
Biological Process	GO:0042060	wound healing	Jag2	IEP		Rat	PMID:11549580|RGD:13506277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern