Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAK1
  • Mouse genes Jak1
  • Rat genes Jak1
  • Zfish genes jak1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jak1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	Jak1	IPI	RGD:620596	Rat	PMID:14674010|RGD:1582346
Molecular Function	GO:0005131	growth hormone receptor binding	Jak1	IPI	UniProtKB:P10912	Mouse	MGI:MGI:4418639|PMID:10502458
Molecular Function	GO:0005131	growth hormone receptor binding	Jak1	IPI	RGD:2687	Rat	PMID:11244571|RGD:1624962
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	JAK1	IDA		Human	PMID:7657660
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	JAK1	IDA		Human	PMID:8232552
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P48551	Human	PMID:16710296
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P40189-1	Human	PMID:21220115
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:Q9UDY2	Human	PMID:21679692
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P40763	Human	PMID:25065853
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:O60674	Human	PMID:26175413
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P42224	Human	PMID:32953130
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P42224	Human	PMID:34521819
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P42224	Human	PMID:34950606
Molecular Function	GO:0005515	protein binding	JAK1	IPI	UniProtKB:P48551	Human	PMID:7759950
Molecular Function	GO:0005515	protein binding	Jak1	IPI	PR:P70451	Mouse	PMID:12738762
Molecular Function	GO:0005515	protein binding	Jak1	IPI	PR:P61372	Mouse	PMID:15659653
Molecular Function	GO:0005515	protein binding	Jak1	IPI	PR:P42227	Mouse	PMID:15659653
Molecular Function	GO:0019903	protein phosphatase binding	JAK1	IPI	UniProtKB:P17706	Human	PMID:11909529
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	EXP		Human	PMID:10825200
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	EXP		Human	PMID:1386289
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	EXP		Human	PMID:31892268
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	IDA		Human	PMID:7532278
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	IDA		Human	PMID:7929391
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	IDA		Human	PMID:7973659
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	IDA		Human	PMID:8272873
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK1	IDA		Human	PMID:8756628
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak1	IMP	MGI:MGI:2176165,MGI:MGI:5688302	Mouse	PMID:27671227
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak1	IDA		Mouse	PMID:10872802
Molecular Function	GO:0140537	transcription regulator activator activity	JAK1	IDA		Human	PMID:8272873
Molecular Function	GO:0031625	ubiquitin protein ligase binding	JAK1	IPI	UniProtKB:Q9C030	Human	PMID:24882218
Cellular Component	GO:0005737	cytoplasm	JAK1	IDA		Human	PMID:10502458
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	JAK1	IDA		Human	PMID:8272873
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	JAK1	IDA		Human	PMID:7973659
Cellular Component	GO:0005925	focal adhesion	JAK1	HDA		Human	PMID:21423176
Cellular Component	GO:0005634	nucleus	JAK1	IDA		Human	PMID:10502458
Biological Process	GO:0036016	cellular response to interleukin-3	Jak1	IDA		Mouse	PMID:8378315
Biological Process	GO:0098761	cellular response to interleukin-7	Jak1	IDA		Mouse	PMID:29581031
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Jak1	IDA		Mouse	PMID:8022486
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Jak1	IDA		Mouse	PMID:8022486
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	JAK1	IDA		Human	PMID:8272872
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	JAK1	IDA		Human	PMID:7568001
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	JAK1	IDA		Human	PMID:11909529
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	JAK1	IDA		Human	PMID:7973659
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	JAK1	IDA		Human	PMID:7929391
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	JAK1	IDA		Human	PMID:8272873
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	JAK1	IDA		Human	PMID:8756628
Biological Process	GO:0035556	intracellular signal transduction	Jak1	IDA		Mouse	PMID:8022486
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Jak1	IDA		Mouse	PMID:10872802
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	JAK1	IMP		Human	PMID:21679692
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	JAK1	IDA		Human	PMID:26479788
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	Jak1	IMP	MGI:MGI:2176165,MGI:MGI:5688302	Mouse	PMID:27671227
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	JAK1	IGI	RNAcentral:URS00002075FA_9606	Human	PMID:20299512
Biological Process	GO:0150105	protein localization to cell-cell junction	JAK1	IMP		Human	PMID:21679692
Biological Process	GO:0006468	protein phosphorylation	JAK1	IMP		Human	PMID:28111307
Biological Process	GO:0006468	protein phosphorylation	JAK1	IMP		Human	PMID:32750333
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK1	IMP		Human	PMID:28111307
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK1	IMP		Human	PMID:32750333
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK1	IDA		Human	PMID:7657660
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK1	IDA		Human	PMID:8232552
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK1	IDA		Human	PMID:8272873
Biological Process	GO:0046677	response to antibiotic	JAK1	IDA		Human	PMID:16280321
Biological Process	GO:0033077	T cell differentiation in thymus	jak1	IMP	ZFIN:ZDB-GENO-121204-3	Zfish	PMID:21562163
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	JAK1	IDA		Human	PMID:7532278
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	JAK1	IDA		Human	PMID:8232552
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	JAK1	IDA		Human	PMID:8232552
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Jak1	IMP	MGI:MGI:2176165,MGI:MGI:5688302	Mouse	PMID:27671227

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern