Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Jak2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes JAK2
- Mouse genes Jak2
- Rat genes Jak2
- Zfish genes jak2a,jak2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jak2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0033130	acetylcholine receptor binding	Jak2	IPI	RGD:2348	Rat	PMID:12244045\|RGD:633056
Molecular Function	GO:0005131	growth hormone receptor binding	Jak2	IPI	UniProtKB:P10912	Rat	PMID:10502458\|RGD:8553995
Molecular Function	GO:0005131	growth hormone receptor binding	Jak2	IPI	RGD:2687	Rat	PMID:11244571\|RGD:1624962
Molecular Function	GO:0020037	heme binding	JAK2	IDA		Human	PMID:21036157
Molecular Function	GO:0042393	histone binding	JAK2	IDA		Human	PMID:19783980
Molecular Function	GO:0035401	histone H3Y41 kinase activity	JAK2	IDA		Human	PMID:19783980
Molecular Function	GO:0042802	identical protein binding	JAK2	IPI	UniProtKB:O60674	Human	PMID:21841788
Molecular Function	GO:0042802	identical protein binding	JAK2	IPI	UniProtKB:O60674	Human	PMID:22820988
Molecular Function	GO:0043560	insulin receptor substrate binding	Jak2	IPI	RGD:2922	Rat	PMID:15701573\|RGD:1641881
Molecular Function	GO:0005143	interleukin-12 receptor binding	Jak2	IPI	PR:P97378	Mouse	PMID:11489994
Molecular Function	GO:0051428	peptide hormone receptor binding	Jak2	IPI	RGD:2687	Rat	PMID:11244571\|RGD:1624962
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Jak2	IPI	RGD:3329	Rat	PMID:15530849\|RGD:1641930
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q96EY1-1	Human	PMID:11679576
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q96EY1-2	Human	PMID:11679576
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P18031	Human	PMID:11694501
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P18031	Human	PMID:11970898
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P18031	Human	PMID:15821101
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P32927	Human	PMID:16437163
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P32927	Human	PMID:18692472
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q9JHI9	Human	PMID:19234114
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P07900	Human	PMID:20353823
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q96Q27	Human	PMID:21119685
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P18031	Human	PMID:21806020
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P40238	Human	PMID:24931576
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q6ZWK4	Human	PMID:25092874
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P23458	Human	PMID:26175413
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:P29597	Human	PMID:26175413
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:O75116	Human	PMID:30413785
Molecular Function	GO:0005515	protein binding	JAK2	IPI	UniProtKB:Q01344	Human	PMID:9516124
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P46527	Mouse	MGI:MGI:5448519\|PMID:21423214
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:Q91ZM2	Mouse	MGI:MGI:5508275\|PMID:15121872
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P14753	Mouse	MGI:MGI:5508729\|PMID:21362419
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P35428\|UniProtKB:P70120	Mouse	MGI:MGI:5284803\|PMID:15156153
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P19941	Mouse	MGI:MGI:3836108\|PMID:17761766
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P10686	Mouse	MGI:MGI:5508616\|PMID:17128263
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P14753	Mouse	MGI:MGI:5508621\|PMID:17024180
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P48356	Mouse	MGI:MGI:4944032\|PMID:21264353
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P29353	Mouse	MGI:MGI:5508319\|PMID:7535773
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P20491	Mouse	MGI:MGI:5568184\|PMID:24608040
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:Q5VWK5	Mouse	MGI:MGI:2180423\|PMID:12023369
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:Q91ZM2	Mouse	MGI:MGI:5508631\|PMID:16824542
Molecular Function	GO:0005515	protein binding	Jak2	IPI	PR:P29351	Mouse	PMID:8943354
Molecular Function	GO:0005515	protein binding	Jak2	IPI	PR:Q9JID9	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P97710	Rat	PMID:16055727\|RGD:13792550
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P15127	Rat	PMID:8912646\|RGD:8553635
Molecular Function	GO:0005515	protein binding	Jak2	IPI	UniProtKB:P41499	Rat	PMID:8912646\|RGD:8553635
Molecular Function	GO:0019901	protein kinase binding	JAK2	IDA		Human	PMID:10925297
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	EXP		Human	PMID:15143187
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	EXP		Human	PMID:19665053
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	EXP		Human	PMID:20304997
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	IDA		Human	PMID:23061660
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	IDA		Human	PMID:8007942
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK2	EXP		Human	PMID:9111318
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IDA		Mouse	MGI:MGI:4457458\|PMID:20304997
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6218056\|PMID:7527668
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6217114\|PMID:10822380
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6216670\|PMID:9111318
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6219204\|PMID:8400282
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6216743\|PMID:7538110
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	EXP		Mouse	MGI:MGI:6216146\|PMID:7961995
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IDA		Mouse	PMID:12147240
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IDA		Mouse	PMID:8378315
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IMP		Mouse	PMID:15012602
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IDA		Mouse	PMID:10872802
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak2	IMP		Rat	PMID:15659221\|RGD:1641883
Molecular Function	GO:0042169	SH2 domain binding	JAK2	IPI	UniProtKB:O15524	Human	PMID:9727029
Molecular Function	GO:0005102	signaling receptor binding	JAK2	IPI	UniProtKB:P06800	Human	PMID:11201744
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Jak2	IPI	RGD:2070	Rat	PMID:9287353\|RGD:5133683
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Jak2	IPI	RGD:2070	Rat	PMID:9314843\|RGD:6478796
Cellular Component	GO:0005901	caveola	Jak2	IDA		Mouse	PMID:12388746
Cellular Component	GO:0005737	cytoplasm	JAK2	IDA		Human	PMID:10502458
Cellular Component	GO:0005737	cytoplasm	Jak2	IDA		Rat	PMID:8756581\|RGD:1641941
Cellular Component	GO:0005829	cytosol	Jak2	IDA		Rat	PMID:16972141\|RGD:1641944
Cellular Component	GO:0000791	euchromatin	Jak2	IDA		Rat	PMID:8756581\|RGD:1641941
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	JAK2	IDA		Human	PMID:8007942
Cellular Component	GO:0019897	extrinsic component of plasma membrane	JAK2	IDA		Human	PMID:8007942
Cellular Component	GO:0005925	focal adhesion	JAK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098978	glutamatergic synapse	Jak2	EXP		Rat	PMID:22284190\|RGD:13702421
Cellular Component	GO:0098978	glutamatergic synapse	Jak2	IDA		Rat	PMID:22284190\|RGD:13702421
Cellular Component	GO:0098978	glutamatergic synapse	Jak2	IMP		Rat	PMID:22284190\|RGD:13702421
Cellular Component	GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	JAK2	IDA		Human	PMID:27396825
Cellular Component	GO:0045121	membrane raft	Jak2	IDA		Mouse	PMID:12388746
Cellular Component	GO:0005730	nucleolus	Jak2	IDA		Rat	PMID:8756581\|RGD:1641941
Cellular Component	GO:0005654	nucleoplasm	JAK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	JAK2	IDA		Human	PMID:10502458
Cellular Component	GO:0005634	nucleus	JAK2	IDA		Human	PMID:19783980
Cellular Component	GO:0005634	nucleus	Jak2	IDA		Mouse	MGI:MGI:5284803\|PMID:15156153
Cellular Component	GO:0005886	plasma membrane	JAK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098794	postsynapse	Jak2	IDA		Rat	PMID:22284190\|RGD:13702421
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Jak2	IDA		Mouse	MGI:MGI:5009182\|PMID:12426001
Biological Process	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Jak2	IDA		Mouse	MGI:MGI:5009182\|PMID:12426001
Biological Process	GO:0042976	activation of Janus kinase activity	Jak2	IDA		Mouse	MGI:MGI:4457458\|PMID:20304997
Biological Process	GO:0031103	axon regeneration	Jak2	IMP		Rat	PMID:15716400\|RGD:1641846
Biological Process	GO:0048514	blood vessel morphogenesis	jak2a	IMP		Zfish	PMID:19059211
Biological Process	GO:0030154	cell differentiation	Jak2	IMP		Mouse	PMID:11821424
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Jak2	IDA		Mouse	PMID:21606371
Biological Process	GO:0036016	cellular response to interleukin-3	Jak2	IDA		Mouse	PMID:8378315
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Jak2	IDA		Mouse	PMID:21606371
Biological Process	GO:0038065	collagen-activated signaling pathway	JAK2	IMP		Human	PMID:31145836
Biological Process	GO:0019221	cytokine-mediated signaling pathway	JAK2	IDA		Human	PMID:8609418
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Jak2	IMP		Mouse	MGI:MGI:1203274\|PMID:9590173
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Jak2	IMP		Mouse	MGI:MGI:1203273\|PMID:9590174
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Jak2	IDA		Mouse	PMID:8022486
Biological Process	GO:0030218	erythrocyte differentiation	Jak2	IMP		Mouse	MGI:MGI:1203274\|PMID:9590173
Biological Process	GO:0030218	erythrocyte differentiation	Jak2	IMP		Mouse	MGI:MGI:1203273\|PMID:9590174
Biological Process	GO:0030218	erythrocyte differentiation	jak2a	IGI	ZFIN:ZDB-MRPHLNO-100427-10	Zfish	PMID:19772888
Biological Process	GO:0030218	erythrocyte differentiation	jak2a	IMP		Zfish	PMID:19772888
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Jak2	IDA		Mouse	PMID:12426001
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Jak2	IMP		Rat	PMID:17021051\|RGD:1641809
Biological Process	GO:0038157	granulocyte-macrophage colony-stimulating factor signaling pathway	JAK2	IDA		Human	PMID:18692472
Biological Process	GO:0060396	growth hormone receptor signaling pathway	JAK2	IDA		Human	PMID:10925297
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Jak2	IMP		Mouse	MGI:MGI:4457458\|PMID:20304997
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Jak2	IDA		Mouse	MGI:MGI:3828422\|PMID:8923468
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Jak2	IDA		Rat	PMID:11244571\|RGD:1624962
Biological Process	GO:0030097	hemopoiesis	jak2a	IMP		Zfish	PMID:19059211
Biological Process	GO:0009755	hormone-mediated signaling pathway	Jak2	IDA		Rat	PMID:11064147\|RGD:1624963
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	JAK2	IDA		Human	PMID:7528775
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	JAK2	IDA		Human	PMID:8007942
Biological Process	GO:0038043	interleukin-5-mediated signaling pathway	JAK2	IDA		Human	PMID:7613138
Biological Process	GO:0035556	intracellular signal transduction	Jak2	IDA		Mouse	PMID:8022486
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Jak2	IMP		Rat	PMID:15659221\|RGD:1641883
Biological Process	GO:0061180	mammary gland epithelium development	Jak2	IMP		Mouse	PMID:12040017
Biological Process	GO:0001774	microglial cell activation	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0031959	mineralocorticoid receptor signaling pathway	Jak2	IMP		Rat	PMID:15932931\|RGD:1641841
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Jak2	IDA		Rat	PMID:22284190\|RGD:13702421
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Jak2	IMP		Rat	PMID:22284190\|RGD:13702421
Biological Process	GO:0030099	myeloid cell differentiation	Jak2	IMP	MGI:MGI:3045147	Mouse	PMID:15354294
Biological Process	GO:0043066	negative regulation of apoptotic process	Jak2	IDA		Mouse	PMID:12147240
Biological Process	GO:0043066	negative regulation of apoptotic process	Jak2	IMP		Rat	PMID:22382519\|RGD:10403070
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Jak2	IMP		Rat	PMID:23796350\|RGD:8694332
Biological Process	GO:0008285	negative regulation of cell population proliferation	Jak2	IMP		Mouse	PMID:11821424
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	Jak2	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:0043392	negative regulation of DNA binding	Jak2	IDA		Mouse	PMID:12388746
Biological Process	GO:0045822	negative regulation of heart contraction	Jak2	IMP		Rat	PMID:12595539\|RGD:1641934
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Jak2	IMP		Rat	PMID:12244045\|RGD:633056
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Jak2	IMP		Rat	PMID:23236988\|RGD:10403076
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Jak2	IDA		Mouse	PMID:10872802
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Jak2	IMP		Rat	PMID:15948243\|RGD:1600095
Biological Process	GO:0043065	positive regulation of apoptotic process	Jak2	IMP		Rat	PMID:16269269\|RGD:1600094
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Jak2	IMP		Mouse	PMID:15012602
Biological Process	GO:0050867	positive regulation of cell activation	Jak2	IMP		Rat	PMID:15256805\|RGD:1641933
Biological Process	GO:0045597	positive regulation of cell differentiation	Jak2	IMP		Rat	PMID:16514419\|RGD:1641813
Biological Process	GO:0030335	positive regulation of cell migration	Jak2	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:0008284	positive regulation of cell population proliferation	Jak2	IMP		Rat	PMID:16567515\|RGD:1641817
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	JAK2	IDA		Human	PMID:10925297
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Jak2	IMP		Mouse	MGI:MGI:5776660\|PMID:26515423
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Jak2	IMP		Rat	PMID:16597920\|RGD:1641815
Biological Process	GO:0043388	positive regulation of DNA binding	Jak2	IMP		Rat	PMID:15322111\|RGD:1641932
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Jak2	IMP		Rat	PMID:15322111\|RGD:1641932
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	Jak2	IMP		Rat	PMID:22777122\|RGD:10403072
Biological Process	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	Jak2	IMP		Rat	PMID:23869758\|RGD:8694323
Biological Process	GO:0060399	positive regulation of growth hormone receptor signaling pathway	Jak2	IMP		Mouse	MGI:MGI:3836108\|PMID:17761766
Biological Process	GO:0050729	positive regulation of inflammatory response	Jak2	IMP		Rat	PMID:16934228\|RGD:1641810
Biological Process	GO:0032024	positive regulation of insulin secretion	Jak2	IMP		Rat	PMID:16597920\|RGD:1641815
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Jak2	IMP		Rat	PMID:16934228\|RGD:1641810
Biological Process	GO:0070665	positive regulation of leukocyte proliferation	JAK2	IDA		Human	PMID:18692472
Biological Process	GO:0043410	positive regulation of MAPK cascade	Jak2	IMP		Rat	PMID:16567515\|RGD:1641817
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	JAK2	IDA		Human	PMID:19088061
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Jak2	IMP		Rat	PMID:12595539\|RGD:1641934
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Jak2	IDA		Mouse	MGI:MGI:5009182\|PMID:12426001
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Jak2	IDA		Mouse	MGI:MGI:5009205\|PMID:10600756
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Jak2	IDA		Rat	PMID:11536325\|RGD:8553830
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	JAK2	IDA		Human	PMID:19088061
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Jak2	IMP		Mouse	MGI:MGI:3828423\|PMID:7782332
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Jak2	IMP		Mouse	MGI:MGI:3828423\|PMID:7782332
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	Jak2	IMP		Rat	PMID:17021051\|RGD:1641809
Biological Process	GO:0010572	positive regulation of platelet activation	JAK2	IDA		Human	PMID:31145836
Biological Process	GO:1901731	positive regulation of platelet aggregation	JAK2	IDA		Human	PMID:31145836
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Jak2	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	JAK2	IDA		Human	PMID:12023369
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	JAK2	IDA		Human	PMID:7638186
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	jak2a	IDA		Zfish	PMID:16459186
Biological Process	GO:2000273	positive regulation of signaling receptor activity	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	JAK2	IGI	UniProtKB:Q5VV43	Human	PMID:28334068
Biological Process	GO:0042102	positive regulation of T cell proliferation	JAK2	IDA		Human	PMID:11114383
Biological Process	GO:0042102	positive regulation of T cell proliferation	Jak2	IDA		Mouse	MGI:MGI:1927676\|PMID:11114383
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Jak2	IGI	MGI:MGI:1933533	Mouse	PMID:20530874
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	jak2a	IDA		Zfish	PMID:16459186
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Jak2	IDA		Mouse	MGI:MGI:5009182\|PMID:12426001
Biological Process	GO:0032729	positive regulation of type II interferon production	JAK2	IDA		Human	PMID:12023369
Biological Process	GO:0032729	positive regulation of type II interferon production	JAK2	IDA		Human	PMID:19088061
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Jak2	IDA		Mouse	MGI:MGI:3828422\|PMID:8923468
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Jak2	IDA		Mouse	MGI:MGI:5284803\|PMID:15156153
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Jak2	IMP		Rat	PMID:23516544\|RGD:10403075
Biological Process	GO:0035166	post-embryonic hemopoiesis	Jak2	IMP		Mouse	MGI:MGI:5505744\|PMID:23544085
Biological Process	GO:0043687	post-translational protein modification	JAK2	IDA		Human	PMID:19783980
Biological Process	GO:0060215	primitive hemopoiesis	jak2a	IMP	ZFIN:ZDB-MRPHLNO-080430-1	Zfish	PMID:17545503
Biological Process	GO:0060215	primitive hemopoiesis	jak2a	IMP	ZFIN:ZDB-MRPHLNO-080428-1	Zfish	PMID:17545503
Biological Process	GO:0034050	programmed cell death induced by symbiont	Jak2	IDA		Mouse	PMID:12426001
Biological Process	GO:0046777	protein autophosphorylation	Jak2	IDA		Mouse	MGI:MGI:4457458\|PMID:20304997
Biological Process	GO:0046777	protein autophosphorylation	Jak2	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:0006468	protein phosphorylation	JAK2	IDA		Human	PMID:18692472
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK2	IDA		Human	PMID:18692472
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	JAK2	IDA		Human	PMID:31145836
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IGI	UniProtKB:P01580	Mouse	MGI:MGI:5776417\|PMID:26227742
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IDA		Mouse	PMID:12147240
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IMP		Mouse	PMID:11821424
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IDA		Mouse	PMID:21606371
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IMP	MGI:MGI:3045147	Mouse	PMID:15354294
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Jak2	IDA		Rat	PMID:11064147\|RGD:1624963
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	jak2a	IMP		Zfish	PMID:19772888
Biological Process	GO:0050727	regulation of inflammatory response	JAK2	IDA		Human	PMID:10925297
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	Jak2	IGI	UniProtKB:P97710	Rat	PMID:16055727\|RGD:13792550
Biological Process	GO:1905539	regulation of postsynapse to nucleus signaling pathway	Jak2	EXP		Rat	PMID:22284190\|RGD:13702421
Biological Process	GO:1905539	regulation of postsynapse to nucleus signaling pathway	Jak2	IDA		Rat	PMID:22284190\|RGD:13702421
Biological Process	GO:0014075	response to amine	Jak2	IEP		Rat	PMID:29486150\|RGD:127285672
Biological Process	GO:0046677	response to antibiotic	JAK2	IDA		Human	PMID:16280321
Biological Process	GO:0033194	response to hydroperoxide	Jak2	IMP		Rat	PMID:15659221\|RGD:1641883
Biological Process	GO:0070671	response to interleukin-12	JAK2	IDA		Human	PMID:7528775
Biological Process	GO:0032496	response to lipopolysaccharide	Jak2	IDA		Mouse	MGI:MGI:5050078\|PMID:11536325
Biological Process	GO:0014070	response to organic cyclic compound	Jak2	IEP		Rat	PMID:29486150\|RGD:127285672
Biological Process	GO:0006979	response to oxidative stress	Jak2	IMP		Rat	PMID:16269269\|RGD:1600094
Biological Process	GO:0034612	response to tumor necrosis factor	JAK2	IDA		Human	PMID:8609418
Biological Process	GO:0007165	signal transduction	Jak2	IMP		Mouse	MGI:MGI:1203273\|PMID:9590174
Biological Process	GO:0007165	signal transduction	Jak2	IMP		Mouse	MGI:MGI:1203274\|PMID:9590173
Biological Process	GO:0006366	transcription by RNA polymerase II	Jak2	IGI	MGI:MGI:1933533	Mouse	PMID:20530874
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	JAK2	IDA		Human	PMID:8609418
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	Jak2	IDA		Rat	PMID:11536325\|RGD:8553830
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Jak2	IMP		Mouse	PMID:11821424
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Jak2	IDA		Mouse	PMID:12388746
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Jak2	IMP		Rat	PMID:15659221\|RGD:1641883
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Jak2	IMP		Rat	PMID:17920330\|RGD:5686906

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.