Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAK3
  • Mouse genes Jak3
  • Rat genes Jak3
  • Zfish genes jak3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jak3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	JAK3	IPI	UniProtKB:P55209	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	JAK3	IPI	UniProtKB:Q9UNF1	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	JAK3	IPI	UniProtKB:P55209	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	JAK3	IPI	UniProtKB:Q9UNF1	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	JAK3	IPI	UniProtKB:Q07666	Human	PMID:9045636
Molecular Function	GO:0005515	protein binding	Jak3	IPI	PR:Q9JID9	Mouse	PMID:10872802
Molecular Function	GO:0019903	protein phosphatase binding	JAK3	IPI	UniProtKB:P17706	Human	PMID:11909529
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK3	IMP		Human	PMID:18250158
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK3	IDA		Human	PMID:18829468
Molecular Function	GO:0004713	protein tyrosine kinase activity	JAK3	IDA		Human	PMID:7973658
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak3	IDA		Mouse	PMID:8022486
Molecular Function	GO:0004713	protein tyrosine kinase activity	Jak3	IDA		Mouse	PMID:10872802
Cellular Component	GO:0005737	cytoplasm	Jak3	IDA		Rat	PMID:9030713|RGD:1600278
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	JAK3	IDA		Human	PMID:7568001
Biological Process	GO:0030183	B cell differentiation	Jak3	IMP		Mouse	MGI:MGI:3655405|PMID:9498750
Biological Process	GO:0071345	cellular response to cytokine stimulus	Jak3	IMP		Mouse	PMID:19414010
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Jak3	IDA		Mouse	PMID:8022486
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Jak3	IDA		Rat	PMID:7518451|RGD:1600268
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Jak3	IDA		Mouse	PMID:8022486
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	JAK3	IDA		Human	PMID:7568001
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	JAK3	IDA		Human	PMID:7973659
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	JAK3	IDA		Human	PMID:7538655
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	JAK3	IDA		Human	PMID:18829468
Biological Process	GO:0035556	intracellular signal transduction	Jak3	IDA		Mouse	PMID:8022486
Biological Process	GO:0030098	lymphocyte differentiation	jak3	IMP	ZFIN:ZDB-MRPHLNO-160527-4	Zfish	PMID:26590317
Biological Process	GO:0001779	natural killer cell differentiation	jak3	IMP	ZFIN:ZDB-GENO-170927-3	Zfish	PMID:27810924
Biological Process	GO:0002731	negative regulation of dendritic cell cytokine production	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:0045221	negative regulation of FasL production	Jak3	IMP		Mouse	MGI:MGI:3655405|PMID:9498750
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:0050868	negative regulation of T cell activation	Jak3	IMP		Mouse	MGI:MGI:3655405|PMID:9498750
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Jak3	IMP		Mouse	MGI:MGI:3619195|PMID:9973401
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Jak3	IDA		Mouse	PMID:10872802
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Jak3	IMP		Rat	PMID:11781254|RGD:1600262
Biological Process	GO:0051928	positive regulation of calcium ion transport	Jak3	IMP		Rat	PMID:16371324|RGD:1600273
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Jak3	IMP		Rat	PMID:16371324|RGD:1600273
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Jak3	IMP		Mouse	MGI:MGI:3719947|PMID:16020505
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Jak3	IMP		Rat	PMID:22788969|RGD:11533941
Biological Process	GO:0042102	positive regulation of T cell proliferation	Jak3	IDA		Rat	PMID:9637481|RGD:8554088
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Jak3	IMP	MGI:MGI:2675061	Mouse	PMID:10485657
Biological Process	GO:0070232	regulation of T cell apoptotic process	Jak3	IMP		Mouse	MGI:MGI:3655405|PMID:9498750
Biological Process	GO:0070670	response to interleukin-4	JAK3	IDA		Human	PMID:7538655
Biological Process	GO:0070670	response to interleukin-4	JAK3	IDA		Human	PMID:7594533
Biological Process	GO:0030217	T cell differentiation	jak3	IMP	ZFIN:ZDB-GENO-170927-3	Zfish	PMID:27810924
Biological Process	GO:0033077	T cell differentiation in thymus	jak3	IMP	ZFIN:ZDB-GENO-121204-2	Zfish	PMID:21562163
Biological Process	GO:0043029	T cell homeostasis	Jak3	IMP		Mouse	MGI:MGI:3655405|PMID:9498750
Biological Process	GO:0006366	transcription by RNA polymerase II	Jak3	IMP	MGI:MGI:2675061	Mouse	PMID:10485657

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern