Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAM2
  • Mouse genes Jam2
  • Rat genes Jam2
  • Zfish genes jam2a,jam2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jam2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	JAM2	IDA		Human	PMID:12070135
Molecular Function	GO:0005515	protein binding	JAM2	IPI	UniProtKB:Q9BX67	Human	PMID:11590146
Molecular Function	GO:0005515	protein binding	JAM2	IPI	UniProtKB:Q9BX67	Human	PMID:11823489
Molecular Function	GO:0005515	protein binding	JAM2	IPI	UniProtKB:Q9BX67	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	Jam2	IPI	PR:Q9D8B7	Mouse	PMID:16093349
Molecular Function	GO:0005515	protein binding	jam2a	IPI	UniProtKB:A3KPA0	Zfish	PMID:18296487
Molecular Function	GO:0046982	protein heterodimerization activity	jam2a	IPI	ZFIN:ZDB-GENE-030131-2416	Zfish	PMID:25119047
Cellular Component	GO:0009986	cell surface	JAM2	IDA		Human	PMID:19740376
Cellular Component	GO:0009986	cell surface	Jam2	IDA		Mouse	MGI:MGI:6316481|PMID:12239159
Cellular Component	GO:0044291	cell-cell contact zone	JAM2	IDA		Human	PMID:12239159
Cellular Component	GO:0005886	plasma membrane	JAM2	IDA		Human	PMID:11590146
Cellular Component	GO:0005886	plasma membrane	JAM2	IMP		Human	PMID:31851307
Cellular Component	GO:0098636	protein complex involved in cell adhesion	JAM2	IDA		Human	PMID:11590146
Cellular Component	GO:0036477	somatodendritic compartment	Jam2	IDA		Mouse	MGI:MGI:5883159|PMID:27499083
Cellular Component	GO:0070160	tight junction	Jam2	IDA		Mouse	MGI:MGI:3054279|PMID:15372036
Biological Process	GO:0098609	cell-cell adhesion	JAM2	IMP		Human	PMID:24357068
Biological Process	GO:0098609	cell-cell adhesion	Jam2	IMP		Mouse	MGI:MGI:5691914|PMID:24357068
Biological Process	GO:0045123	cellular extravasation	JAM2	IDA		Human	PMID:12239159
Biological Process	GO:0045123	cellular extravasation	Jam2	IDA		Mouse	MGI:MGI:6316481|PMID:12239159
Biological Process	GO:0048534	hematopoietic or lymphoid organ development	jam2a	IMP	ZFIN:ZDB-MRPHLNO-120130-1	Zfish	PMID:25119047
Biological Process	GO:0048534	hematopoietic or lymphoid organ development	jam2a	IMP	ZFIN:ZDB-GENO-120127-11	Zfish	PMID:25119047
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	JAM2	IMP		Human	PMID:24357068
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	Jam2	IMP		Mouse	MGI:MGI:5691914|PMID:24357068
Biological Process	GO:0050901	leukocyte tethering or rolling	JAM2	IDA		Human	PMID:19740376
Biological Process	GO:0050901	leukocyte tethering or rolling	Jam2	IDA		Mouse	MGI:MGI:6316549|PMID:19740376
Biological Process	GO:0071593	lymphocyte aggregation	JAM2	IDA		Human	PMID:11823489
Biological Process	GO:0007520	myoblast fusion	jam2a	IMP	ZFIN:ZDB-GENO-120127-11	Zfish	PMID:30467785
Biological Process	GO:0007520	myoblast fusion	jam2a	IGI	ZFIN:ZDB-GENO-120127-11,ZFIN:ZDB-MRPHLNO-120130-2	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam2a	IGI	ZFIN:ZDB-GENO-120130-990,ZFIN:ZDB-MRPHLNO-120130-1	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam2a	IMP	ZFIN:ZDB-GENO-120127-11	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam2a	IMP	ZFIN:ZDB-MRPHLNO-120130-1	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam2a	IGI	ZFIN:ZDB-GENO-120127-11,ZFIN:ZDB-GENO-120130-990	Zfish	PMID:22180726
Biological Process	GO:0007162	negative regulation of cell adhesion	Jam2	IGI	MGI:MGI:1933825	Mouse	PMID:16093349
Biological Process	GO:0007162	negative regulation of cell adhesion	Jam2	IGI	MGI:MGI:96611	Mouse	PMID:16093349
Biological Process	GO:0007162	negative regulation of cell adhesion	Jam2	IGI	MGI:MGI:96607	Mouse	PMID:16093349
Biological Process	GO:0031642	negative regulation of myelination	Jam2	IMP		Mouse	MGI:MGI:5883159|PMID:27499083
Biological Process	GO:2000403	positive regulation of lymphocyte migration	JAM2	IDA		Human	PMID:12239159
Biological Process	GO:2000403	positive regulation of lymphocyte migration	Jam2	IMP		Mouse	MGI:MGI:6316481|PMID:12239159
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	jam2a	IMP	ZFIN:ZDB-GENO-210728-4	Zfish	PMID:32165147
Biological Process	GO:0007286	spermatid development	Jam2	IDA		Mouse	MGI:MGI:3054279|PMID:15372036

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern