Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JAM3
  • Mouse genes Jam3
  • Rat genes Jam3
  • Zfish genes jam3a,jam3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jam3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	JAM3	IDA		Human	PMID:11823489
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	JAM3	IDA		Human	PMID:19740376
Molecular Function	GO:0042802	identical protein binding	Jam3	IPI	PR:Q9D8B7	Mouse	PMID:16093349
Molecular Function	GO:0005178	integrin binding	JAM3	IPI	UniProtKB:P05107	Human	PMID:12208882
Molecular Function	GO:0005178	integrin binding	JAM3	IPI	UniProtKB:P11215	Human	PMID:12208882
Molecular Function	GO:0005178	integrin binding	JAM3	IPI	UniProtKB:P11215	Human	PMID:15194813
Molecular Function	GO:0005178	integrin binding	JAM3	IPI	UniProtKB:P05106	Human	PMID:19461049
Molecular Function	GO:0005178	integrin binding	Jam3	IPI	PR:P11835	Mouse	PMID:16093349
Molecular Function	GO:0005178	integrin binding	Jam3	IPI	PR:P05555	Mouse	PMID:16093349
Molecular Function	GO:0005515	protein binding	JAM3	IPI	UniProtKB:P57087	Human	PMID:11590146
Molecular Function	GO:0005515	protein binding	JAM3	IPI	UniProtKB:P57087	Human	PMID:11823489
Molecular Function	GO:0005515	protein binding	JAM3	IPI	UniProtKB:P55196	Human	PMID:19461049
Molecular Function	GO:0005515	protein binding	JAM3	IPI	UniProtKB:P57087	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	JAM3	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Jam3	IPI	PR:Q99NH2	Mouse	PMID:18055550
Molecular Function	GO:0005515	protein binding	Jam3	IPI	PR:Q8R5M8	Mouse	PMID:18055550
Molecular Function	GO:0005515	protein binding	Jam3	IPI	PR:Q9JI59	Mouse	PMID:16093349
Molecular Function	GO:0005515	protein binding	Jam3	IPI	PR:P97792	Mouse	PMID:16410001
Molecular Function	GO:0005515	protein binding	jam3b	IPI	UniProtKB:A4JYM3	Zfish	PMID:22180726|ZFIN:ZDB-PUB-120105-71
Molecular Function	GO:0005515	protein binding	jam3b	IPI	UniProtKB:A4JYM3	Zfish	PMID:18296487
Cellular Component	GO:0005923	bicellular tight junction	JAM3	IDA		Human	PMID:28196865
Cellular Component	GO:0005923	bicellular tight junction	Jam3	IDA		Mouse	PMID:17853450
Cellular Component	GO:0044291	cell-cell contact zone	JAM3	IDA		Human	PMID:15994945
Cellular Component	GO:0005911	cell-cell junction	JAM3	IMP		Human	PMID:19461049
Cellular Component	GO:0005911	cell-cell junction	Jam3	IDA		Mouse	PMID:17099249
Cellular Component	GO:0005911	cell-cell junction	Jam3	IDA		Mouse	PMID:16093349
Cellular Component	GO:0005911	cell-cell junction	Jam3	IDA		Mouse	PMID:17853450
Cellular Component	GO:0005911	cell-cell junction	Jam3	IDA		Mouse	PMID:15372036
Cellular Component	GO:0030057	desmosome	JAM3	IDA		Human	PMID:15194813
Cellular Component	GO:0005615	extracellular space	JAM3	IDA		Human	PMID:20592283
Cellular Component	GO:0031941	filamentous actin	JAM3	IDA		Human	PMID:19060272
Cellular Component	GO:0005794	Golgi apparatus	JAM3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005902	microvillus	JAM3	IDA		Human	PMID:19060272
Cellular Component	GO:0033010	paranodal junction	Jam3	IDA		Mouse	PMID:21097846
Cellular Component	GO:0033010	paranodal junction	Jam3	IDA		Mouse	PMID:18048693
Cellular Component	GO:0005886	plasma membrane	JAM3	IDA		Human	PMID:11590146
Cellular Component	GO:0005886	plasma membrane	JAM3	IDA		Human	PMID:19461049
Cellular Component	GO:0098636	protein complex involved in cell adhesion	JAM3	IDA		Human	PMID:11590146
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	Jam3	IDA		Mouse	PMID:21097846
Cellular Component	GO:0070160	tight junction	JAM3	IDA		Human	PMID:19060272
Biological Process	GO:0002250	adaptive immune response	Jam3	IMP	MGI:MGI:3055281	Mouse	PMID:19342649
Biological Process	GO:0034333	adherens junction assembly	JAM3	IMP		Human	PMID:19060272
Biological Process	GO:0001525	angiogenesis	JAM3	IDA		Human	PMID:20592283
Biological Process	GO:0001525	angiogenesis	Jam3	IDA		Mouse	MGI:MGI:5009412|PMID:15994945
Biological Process	GO:0045176	apical protein localization	JAM3	IMP	UniProtKB:P15311	Human	PMID:19060272
Biological Process	GO:0031103	axon regeneration	Jam3	IEP		Rat	PMID:22950044|RGD:7488944
Biological Process	GO:0007155	cell adhesion	Jam3	IGI	MGI:MGI:96611	Mouse	PMID:16093349
Biological Process	GO:0007155	cell adhesion	Jam3	IGI	MGI:MGI:96607	Mouse	PMID:16093349
Biological Process	GO:0007155	cell adhesion	Jam3	IGI	MGI:MGI:96611	Mouse	PMID:19342649
Biological Process	GO:0007155	cell adhesion	Jam3	IGI	MGI:MGI:96607	Mouse	PMID:19342649
Biological Process	GO:0007155	cell adhesion	Jam3	IGI	MGI:MGI:1933820	Mouse	PMID:16093349
Biological Process	GO:0007155	cell adhesion	Jam3	IMP		Mouse	PMID:16093349
Biological Process	GO:0016477	cell migration	Jam3	IDA		Mouse	PMID:17099249
Biological Process	GO:0098609	cell-cell adhesion	JAM3	IDA		Human	PMID:11823489
Biological Process	GO:0098609	cell-cell adhesion	JAM3	IDA		Human	PMID:19740376
Biological Process	GO:0098609	cell-cell adhesion	JAM3	IMP		Human	PMID:24357068
Biological Process	GO:0098609	cell-cell adhesion	Jam3	IMP		Mouse	MGI:MGI:5691914|PMID:24357068
Biological Process	GO:0007160	cell-matrix adhesion	Jam3	IDA		Mouse	PMID:17099249
Biological Process	GO:0007160	cell-matrix adhesion	Jam3	IGI	MGI:MGI:96610	Mouse	PMID:17099249
Biological Process	GO:0007160	cell-matrix adhesion	Jam3	IGI	MGI:MGI:96612	Mouse	PMID:17099249
Biological Process	GO:0030010	establishment of cell polarity	Jam3	IDA		Mouse	PMID:17099249
Biological Process	GO:0097530	granulocyte migration	JAM3	IMP		Human	PMID:19060272
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	JAM3	IMP		Human	PMID:24357068
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	Jam3	IMP		Mouse	MGI:MGI:5691914|PMID:24357068
Biological Process	GO:0034113	heterotypic cell-cell adhesion	JAM3	IDA		Human	PMID:12208882
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Jam3	IMP		Mouse	PMID:15879142
Biological Process	GO:0042552	myelination	Jam3	IMP		Mouse	PMID:18048693
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Jam3	IMP		Mouse	PMID:19109565
Biological Process	GO:0007520	myoblast fusion	jam3b	IMP	ZFIN:ZDB-GENO-120130-990	Zfish	PMID:30467785
Biological Process	GO:0007520	myoblast fusion	jam3b	IGI	ZFIN:ZDB-GENO-120127-11,ZFIN:ZDB-GENO-120130-990	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam3b	IGI	ZFIN:ZDB-GENO-120127-11,ZFIN:ZDB-MRPHLNO-120130-2	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam3b	IMP	ZFIN:ZDB-GENO-120130-990	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam3b	IMP	ZFIN:ZDB-MRPHLNO-120130-2	Zfish	PMID:22180726
Biological Process	GO:0007520	myoblast fusion	jam3b	IGI	ZFIN:ZDB-GENO-120130-990,ZFIN:ZDB-MRPHLNO-120130-1	Zfish	PMID:22180726
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	JAM3	IMP		Human	PMID:19461049
Biological Process	GO:0033624	negative regulation of integrin activation	JAM3	IMP		Human	PMID:19461049
Biological Process	GO:0001780	neutrophil homeostasis	Jam3	IMP	MGI:MGI:3055281	Mouse	PMID:17455169
Biological Process	GO:0002693	positive regulation of cellular extravasation	JAM3	IMP		Human	PMID:31926946
Biological Process	GO:1905710	positive regulation of membrane permeability	JAM3	IMP		Human	PMID:31926946
Biological Process	GO:1902414	protein localization to cell junction	JAM3	IMP	UniProtKB:Q07157	Human	PMID:19060272
Biological Process	GO:0034394	protein localization to cell surface	JAM3	IMP	UniProtKB:P19022	Human	PMID:19060272
Biological Process	GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion	Jam3	IMP	MGI:MGI:3055281	Mouse	PMID:15372036
Biological Process	GO:0090022	regulation of neutrophil chemotaxis	JAM3	IDA		Human	PMID:15194813
Biological Process	GO:0007286	spermatid development	Jam3	IMP	MGI:MGI:3055281	Mouse	PMID:15372036
Biological Process	GO:0007283	spermatogenesis	Jam3	IMP	MGI:MGI:3055281	Mouse	PMID:15372036
Biological Process	GO:0019226	transmission of nerve impulse	Jam3	IMP		Mouse	PMID:18048693

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern