Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes JUP
  • Mouse genes Jup
  • Rat genes Jup
  • Zfish genes jupa,jupb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Jup

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045294	alpha-catenin binding	JUP	IPI	UniProtKB:Q9UI47	Human	PMID:23136403
Molecular Function	GO:0045294	alpha-catenin binding	JUP	IPI	UniProtKB:P35221	Human	PMID:7650039
Molecular Function	GO:0045294	alpha-catenin binding	JUP	IPI	UniProtKB:P35221	Human	PMID:7890674
Molecular Function	GO:0045294	alpha-catenin binding	Jup	IPI	PR:P26231	Mouse	PMID:14579029
Molecular Function	GO:0045296	cadherin binding	JUP	IPI	UniProtKB:P10288	Human	PMID:1639850
Molecular Function	GO:0045296	cadherin binding	JUP	IPI	UniProtKB:P12830	Human	PMID:1639850
Molecular Function	GO:0045296	cadherin binding	JUP	HDA		Human	PMID:25468996
Molecular Function	GO:0045296	cadherin binding	JUP	IPI	UniProtKB:P19022	Human	PMID:7650039
Molecular Function	GO:0050839	cell adhesion molecule binding	JUP	IPI	UniProtKB:Q14126	Human	PMID:17559062
Molecular Function	GO:0106006	cytoskeletal protein-membrane anchor activity	JUP	IDA		Human	PMID:9049256
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P16284	Human	PMID:10801826
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q99959	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q12913	Human	PMID:12370829
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9NQB0	Human	PMID:14661054
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9UJU2	Human	PMID:14661054
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q96HA8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9NSA3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P15924	Human	PMID:16917092
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P19022	Human	PMID:17098867
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P23327	Human	PMID:17924338
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q96HA8	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q02413	Human	PMID:19136012
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9Y446	Human	PMID:20859650
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P25054	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P25054	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q14192	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:O15169	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P25054	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:A0A0S2Z4M1	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:O15169	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q14192	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P0CG20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P26196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q14192	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9NQB0-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9NSA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9UHP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q9UI47-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P19022	Human	PMID:7650039
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:P25054	Human	PMID:7890674
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q02413	Human	PMID:7983064
Molecular Function	GO:0005515	protein binding	JUP	IPI	UniProtKB:Q14574-1	Human	PMID:7983064
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:P55849	Mouse	PMID:14673151
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:Q99M80	Mouse	PMID:16973135
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:P26231	Mouse	PMID:14579029
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:Q61495	Mouse	PMID:12847106
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:P09803	Mouse	PMID:12847106
Molecular Function	GO:0005515	protein binding	Jup	IPI	PR:P55849	Mouse	PMID:12847106
Molecular Function	GO:0005515	protein binding	Jup	IPI	UniProtKB:Q02487	Rat	PMID:21062920|RGD:8553494
Molecular Function	GO:0005515	protein binding	Jup	IPI	RGD:69247	Rat	PMID:23066018|RGD:7296922
Molecular Function	GO:0019901	protein kinase binding	Jup	IPI	RGD:1306273	Rat	PMID:12700184|RGD:2291909
Molecular Function	GO:0019903	protein phosphatase binding	JUP	IPI	UniProtKB:Q15262	Human	PMID:8663237
Molecular Function	GO:1990782	protein tyrosine kinase binding	Jup	IPI	RGD:1306273	Rat	PMID:12700184|RGD:2291909
Molecular Function	GO:0044877	protein-containing complex binding	Jup	IPI	RGD:69280|RGD:1359485	Rat	PMID:8834786|RGD:2291902
Molecular Function	GO:0003713	transcription coactivator activity	JUP	IDA		Human	PMID:14661054
Cellular Component	GO:0015629	actin cytoskeleton	Jup	IDA		Rat	PMID:12478657|RGD:633036
Cellular Component	GO:0005912	adherens junction	JUP	IDA		Human	PMID:10403777
Cellular Component	GO:0005912	adherens junction	Jup	IDA		Mouse	PMID:8582267
Cellular Component	GO:0005912	adherens junction	Jup	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005912	adherens junction	Jup	IDA		Rat	PMID:8834786|RGD:2291902
Cellular Component	GO:0005912	adherens junction	jupa	IDA		Zfish	PMID:15494018
Cellular Component	GO:0005912	adherens junction	jupa	IDA		Zfish	PMID:10456847
Cellular Component	GO:0016327	apicolateral plasma membrane	Jup	IDA		Rat	PMID:10335358|RGD:2291899
Cellular Component	GO:0016342	catenin complex	JUP	IDA		Human	PMID:7650039
Cellular Component	GO:0016342	catenin complex	Jup	IDA		Mouse	PMID:8853988
Cellular Component	GO:0016342	catenin complex	jupa	IDA		Zfish	PMID:10456847
Cellular Component	GO:0005911	cell-cell junction	JUP	IDA		Human	PMID:10460003
Cellular Component	GO:0005911	cell-cell junction	JUP	IDA		Human	PMID:14661054
Cellular Component	GO:0005911	cell-cell junction	JUP	IDA		Human	PMID:1639850
Cellular Component	GO:0005911	cell-cell junction	JUP	IDA		Human	PMID:7650039
Cellular Component	GO:0005911	cell-cell junction	JUP	IDA		Human	PMID:7983064
Cellular Component	GO:0005911	cell-cell junction	Jup	IDA		Mouse	PMID:12847106
Cellular Component	GO:0005911	cell-cell junction	Jup	IDA		Mouse	PMID:18816447
Cellular Component	GO:0005911	cell-cell junction	Jup	IDA		Mouse	PMID:21296051
Cellular Component	GO:0005911	cell-cell junction	Jup	IDA		Rat	PMID:12478657|RGD:633036
Cellular Component	GO:0001533	cornified envelope	Jup	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005737	cytoplasm	JUP	IMP		Human	PMID:14661054
Cellular Component	GO:0005737	cytoplasm	Jup	IDA		Rat	PMID:12478657|RGD:633036
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Jup	IDA		Rat	PMID:12478657|RGD:633036
Cellular Component	GO:0005829	cytosol	Jup	IDA		Mouse	PMID:12847106
Cellular Component	GO:0030057	desmosome	JUP	IDA		Human	PMID:1639850
Cellular Component	GO:0030057	desmosome	JUP	IDA		Human	PMID:2726765
Cellular Component	GO:0030057	desmosome	Jup	IMP		Mouse	MGI:MGI:5295503|PMID:21880664
Cellular Component	GO:0030057	desmosome	Jup	IDA		Mouse	PMID:10662781
Cellular Component	GO:0030057	desmosome	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:18496566
Cellular Component	GO:0030057	desmosome	Jup	IDA		Mouse	PMID:15775979
Cellular Component	GO:0030057	desmosome	Jup	IDA		Mouse	PMID:14673151
Cellular Component	GO:0030057	desmosome	Jup	IDA		Mouse	PMID:9864371
Cellular Component	GO:0030057	desmosome	Jup	IDA		Rat	PMID:16406610|RGD:1581654
Cellular Component	GO:0030057	desmosome	Jup	IDA		Rat	PMID:26858265|RGD:11526329
Cellular Component	GO:0030057	desmosome	jupa	IDA		Zfish	PMID:10456847
Cellular Component	GO:0070062	extracellular exosome	JUP	HDA		Human	PMID:19056867
Cellular Component	GO:0005916	fascia adherens	Jup	IDA		Rat	PMID:16406610|RGD:1581654
Cellular Component	GO:0005925	focal adhesion	JUP	HDA		Human	PMID:21423176
Cellular Component	GO:0071665	gamma-catenin-TCF7L2 complex	JUP	IDA		Human	PMID:14661054
Cellular Component	GO:0014704	intercalated disc	JUP	IDA		Human	PMID:22781308
Cellular Component	GO:0014704	intercalated disc	JUP	IDA		Human	PMID:22889254
Cellular Component	GO:0014704	intercalated disc	JUP	IDA		Human	PMID:23381804
Cellular Component	GO:0005882	intermediate filament	Jup	IDA		Mouse	MGI:MGI:3723417|PMID:16917092
Cellular Component	GO:0016328	lateral plasma membrane	Jup	IDA		Rat	PMID:10335358|RGD:2291899
Cellular Component	GO:0005634	nucleus	JUP	IMP		Human	PMID:14661054
Cellular Component	GO:0005634	nucleus	jupa	IDA		Zfish	PMID:15494018
Cellular Component	GO:0005886	plasma membrane	JUP	IDA		Human	PMID:14661054
Cellular Component	GO:0005886	plasma membrane	JUP	IDA		Human	PMID:20859650
Cellular Component	GO:0032993	protein-DNA complex	JUP	IDA		Human	PMID:14661054
Cellular Component	GO:0030018	Z disc	Jup	IDA		Mouse	PMID:8821035
Biological Process	GO:0003181	atrioventricular valve morphogenesis	jupa	IMP	ZFIN:ZDB-MRPHLNO-091103-3	Zfish	PMID:19101534
Biological Process	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	JUP	IMP		Human	PMID:17924338
Biological Process	GO:0007155	cell adhesion	Jup	IDA		Mouse	PMID:12847106
Biological Process	GO:0016477	cell migration	JUP	IMP		Human	PMID:18937352
Biological Process	GO:0098609	cell-cell adhesion	JUP	IDA		Human	PMID:18937352
Biological Process	GO:0098609	cell-cell adhesion	JUP	IMP		Human	PMID:20859650
Biological Process	GO:0098609	cell-cell adhesion	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:8954745
Biological Process	GO:0071681	cellular response to indole-3-methanol	JUP	IDA		Human	PMID:10868478
Biological Process	GO:0002159	desmosome assembly	JUP	IMP		Human	PMID:20859650
Biological Process	GO:0002159	desmosome assembly	JUP	IDA		Human	PMID:9049256
Biological Process	GO:0002159	desmosome assembly	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:8954745
Biological Process	GO:0002159	desmosome assembly	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:18496566
Biological Process	GO:0002159	desmosome assembly	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:9847250
Biological Process	GO:0050982	detection of mechanical stimulus	JUP	IDA		Human	PMID:18937352
Biological Process	GO:0007507	heart development	jupa	IMP	ZFIN:ZDB-MRPHLNO-091103-3	Zfish	PMID:19101534
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	JUP	IGI	RNAcentral:URS00005A31EB_9606	Human	PMID:28115160
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	jupa	IMP	ZFIN:ZDB-MRPHLNO-091103-3	Zfish	PMID:19101534
Biological Process	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	jupa	IGI	ZFIN:ZDB-GENE-990708-5,ZFIN:ZDB-MRPHLNO-091103-3	Zfish	PMID:19101534
Biological Process	GO:0045766	positive regulation of angiogenesis	JUP	IGI	RNAcentral:URS00005A31EB_9606	Human	PMID:28115160
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	JUP	IGI	RNAcentral:URS00005A31EB_9606	Human	PMID:28115160
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	JUP	IDA		Human	PMID:14661054
Biological Process	GO:0042307	positive regulation of protein import into nucleus	JUP	IDA		Human	PMID:10825188
Biological Process	GO:0042307	positive regulation of protein import into nucleus	JUP	IDA		Human	PMID:14661054
Biological Process	GO:0072659	protein localization to plasma membrane	JUP	IMP		Human	PMID:20859650
Biological Process	GO:0042127	regulation of cell population proliferation	JUP	IDA		Human	PMID:17924338
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	JUP	IMP		Human	PMID:17924338
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	JUP	IMP		Human	PMID:17924338
Biological Process	GO:0043588	skin development	Jup	IMP	MGI:MGI:1857539	Mouse	PMID:8954745

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern