Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KAT8
  • Mouse genes Kat8
  • Rat genes Kat8
  • Zfish genes kat8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kat8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016407	acetyltransferase activity	Kat8	IDA		Mouse	MGI:MGI:3852588|PMID:19578370
Molecular Function	GO:0019899	enzyme binding	Kat8	IPI	UniProtKB:Q91YE5	Mouse	MGI:MGI:3852588|PMID:19578370
Molecular Function	GO:0046972	histone H4K16 acetyltransferase activity	KAT8	IDA		Human	PMID:20018852
Molecular Function	GO:0046972	histone H4K16 acetyltransferase activity	KAT8	IDA		Human	PMID:31794431
Molecular Function	GO:0046972	histone H4K16 acetyltransferase activity	Kat8	IMP		Mouse	MGI:MGI:6479278|PMID:31794431
Molecular Function	GO:0043995	histone H4K5 acetyltransferase activity	KAT8	IDA		Human	PMID:20018852
Molecular Function	GO:0043996	histone H4K8 acetyltransferase activity	KAT8	IDA		Human	PMID:20018852
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:Q01196-1	Human	PMID:11742995
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:Q13950	Human	PMID:11965546
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:P04637	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:Q03164	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:Q99496	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:P04637	Human	PMID:16601686
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:P02309	Human	PMID:22020126
Molecular Function	GO:0005515	protein binding	KAT8	IPI	UniProtKB:Q8N5Y2	Human	PMID:30224647
Molecular Function	GO:0005515	protein binding	Kat8	IPI	UniProtKB:Q6PDM1|UniProtKB:Q922L6	Mouse	MGI:MGI:3706282|PMID:17335777
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	KAT8	IDA		Human	PMID:11965546
Molecular Function	GO:0003713	transcription coactivator activity	KAT8	IDA		Human	PMID:11742995
Cellular Component	GO:0000123	histone acetyltransferase complex	KAT8	IDA		Human	PMID:20018852
Cellular Component	GO:0000776	kinetochore	Kat8	IDA		Mouse	PMID:14519686
Cellular Component	GO:0071339	MLL1 complex	KAT8	IDA		Human	PMID:15960975
Cellular Component	GO:0072487	MSL complex	KAT8	IDA		Human	PMID:20018852
Cellular Component	GO:0072487	MSL complex	KAT8	IDA		Human	PMID:31794431
Cellular Component	GO:0044545	NSL complex	KAT8	IDA		Human	PMID:20018852
Cellular Component	GO:0016363	nuclear matrix	Kat8	IDA		Mouse	PMID:21746928
Cellular Component	GO:0005654	nucleoplasm	KAT8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KAT8	IDA		Human	PMID:11742995
Cellular Component	GO:0005634	nucleus	KAT8	IDA		Human	PMID:16227571
Cellular Component	GO:0005634	nucleus	KAT8	IDA		Human	PMID:31794431
Biological Process	GO:0043984	histone H4-K16 acetylation	KAT8	IDA		Human	PMID:16227571
Biological Process	GO:0043984	histone H4-K16 acetylation	KAT8	IDA		Human	PMID:20018852
Biological Process	GO:0043981	histone H4-K5 acetylation	KAT8	IDA		Human	PMID:20018852
Biological Process	GO:0043982	histone H4-K8 acetylation	KAT8	IDA		Human	PMID:20018852
Biological Process	GO:0030099	myeloid cell differentiation	KAT8	IDA		Human	PMID:11742995
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	KAT8	IDA		Human	PMID:11742995
Biological Process	GO:0022008	neurogenesis	KAT8	IDA		Human	PMID:31794431
Biological Process	GO:0022008	neurogenesis	Kat8	IMP		Mouse	MGI:MGI:6479278|PMID:31794431
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KAT8	IDA		Human	PMID:11742995
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KAT8	IDA		Human	PMID:11965546
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Kat8	IMP		Mouse	MGI:MGI:6207704|PMID:24842875
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	KAT8	IDA		Human	PMID:24244196
Biological Process	GO:0060215	primitive hemopoiesis	kat8	IMP	ZFIN:ZDB-MRPHLNO-141120-3	Zfish	PMID:24240475
Biological Process	GO:0010506	regulation of autophagy	KAT8	IDA		Human	PMID:23863932
Biological Process	GO:1900095	regulation of dosage compensation by inactivation of X chromosome	Kat8	IDA		Mouse	MGI:MGI:6207704|PMID:24842875

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern