Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcna1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNA1
- Mouse genes Kcna1
- Rat genes Kcna1
- Zfish genes kcna1a,kcna1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcna1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNA1	IDA		Human	PMID:19912772
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna1	IDA		Mouse	MGI:MGI:5605952\|PMID:15361858
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna1	IMP		Rat	PMID:14602579\|RGD:1300201
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna1	IDA		Rat	PMID:22206926\|RGD:10047237
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna1	IDA		Rat	PMID:8038169\|RGD:10047389
Molecular Function	GO:0097718	disordered domain specific binding	KCNA1	IPI	UniProtKB:Q14722	Human	PMID:10585425
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:P78352	Human	PMID:11937501
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q62936	Human	PMID:11937501
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q8N5I3	Human	PMID:19968958
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:G5E8K5	Human	PMID:23903368
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:P21145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:P22001	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q16322	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q8N2M4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q9BQE5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q9UPQ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNA1	IPI	UniProtKB:Q9Y5U9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kcna1	IPI	UniProtKB:Q9R1V4	Mouse	MGI:MGI:5695673\|PMID:26269648
Molecular Function	GO:0005515	protein binding	Kcna1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:25707359
Molecular Function	GO:0005515	protein binding	Kcna1	IPI	UniProtKB:Q8K4Y5	Rat	PMID:16504945\|RGD:8554700
Molecular Function	GO:0005515	protein binding	Kcna1	IPI	UniProtKB:P78352	Rat	PMID:7477295\|RGD:8554588
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Kcna1	IDA		Rat	PMID:8126562\|RGD:13702140
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Kcna1	IMP		Rat	PMID:8126562\|RGD:13702140
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcna1	IDA		Rat	PMID:8126562\|RGD:13702140
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcna1	IMP		Rat	PMID:8126562\|RGD:13702140
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNA1	IMP		Human	PMID:10585425
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNA1	IDA		Human	PMID:19912772
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcna1	IDA		Mouse	MGI:MGI:5605952\|PMID:15361858
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcna1	IMP		Rat	PMID:2555158\|RGD:69870
Cellular Component	GO:0016324	apical plasma membrane	Kcna1	IDA		Rat	PMID:14602579\|RGD:1300201
Cellular Component	GO:0030424	axon	Kcna1	IDA		Mouse	MGI:MGI:4947004\|PMID:21233214
Cellular Component	GO:0030424	axon	Kcna1	IDA		Mouse	MGI:MGI:5695673\|PMID:26269648
Cellular Component	GO:0030424	axon	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0043194	axon initial segment	Kcna1	IDA		Mouse	PMID:18509034
Cellular Component	GO:0043679	axon terminus	Kcna1	IDA		Mouse	MGI:MGI:4947004\|PMID:21233214
Cellular Component	GO:0044305	calyx of Held	Kcna1	IDA		Rat	PMID:14614103\|RGD:13702408
Cellular Component	GO:0030054	cell junction	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0009986	cell surface	Kcna1	IDA		Mouse	PMID:23836929
Cellular Component	GO:0009986	cell surface	Kcna1	IDA		Rat	PMID:22206926\|RGD:10047237
Cellular Component	GO:0005829	cytosol	Kcna1	IDA		Rat	PMID:8038169\|RGD:10047389
Cellular Component	GO:0030425	dendrite	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0030425	dendrite	Kcna1	IDA		Mouse	PMID:23836929
Cellular Component	GO:0030425	dendrite	Kcna1	IDA		Rat	PMID:19166515\|RGD:6483326
Cellular Component	GO:0005783	endoplasmic reticulum	Kcna1	IDA		Rat	PMID:10896669\|RGD:10047332
Cellular Component	GO:0098978	glutamatergic synapse	Kcna1	IDA		Rat	PMID:14614103\|RGD:13702408
Cellular Component	GO:0044224	juxtaparanode region of axon	KCNA1	IDA		Human	PMID:11086297
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna1	IDA		Mouse	MGI:MGI:5607246\|PMID:8361541
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna1	IDA		Mouse	MGI:MGI:2675531\|PMID:12963709
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna1	IDA		Mouse	PMID:18760366
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcna1	IDA		Rat	PMID:11086297\|RGD:10047340
Cellular Component	GO:0043025	neuronal cell body	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0043025	neuronal cell body	Kcna1	IDA		Mouse	PMID:23836929
Cellular Component	GO:0043025	neuronal cell body	Kcna1	IDA		Rat	PMID:10896669\|RGD:10047332
Cellular Component	GO:0043025	neuronal cell body	Kcna1	IDA		Rat	PMID:19166515\|RGD:6483326
Cellular Component	GO:0033270	paranode region of axon	KCNA1	IDA		Human	PMID:11086297
Cellular Component	GO:0033270	paranode region of axon	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0033270	paranode region of axon	Kcna1	IDA		Rat	PMID:11086297\|RGD:10047340
Cellular Component	GO:0043204	perikaryon	Kcna1	IDA		Mouse	MGI:MGI:5695673\|PMID:26269648
Cellular Component	GO:0005886	plasma membrane	KCNA1	IDA		Human	PMID:17136396
Cellular Component	GO:0005886	plasma membrane	KCNA1	IMP		Human	PMID:19912772
Cellular Component	GO:0005886	plasma membrane	Kcna1	IMP		Mouse	MGI:MGI:5605952\|PMID:15361858
Cellular Component	GO:0005886	plasma membrane	Kcna1	IDA		Rat	PMID:22206926\|RGD:10047237
Cellular Component	GO:0005886	plasma membrane	Kcna1	IMP		Rat	PMID:2555158\|RGD:69870
Cellular Component	GO:0005886	plasma membrane	Kcna1	IDA		Rat	PMID:8038169\|RGD:10047389
Cellular Component	GO:0045211	postsynaptic membrane	Kcna1	IDA		Rat	PMID:14614103\|RGD:13702408
Cellular Component	GO:0034705	potassium channel complex	Kcna1	IDA		Rat	PMID:10896669\|RGD:10047332
Cellular Component	GO:0034705	potassium channel complex	Kcna1	IDA		Rat	PMID:9334400\|RGD:10047182
Cellular Component	GO:0042734	presynaptic membrane	Kcna1	IDA		Rat	PMID:14614103\|RGD:13702408
Cellular Component	GO:0042734	presynaptic membrane	Kcna1	IDA		Rat	PMID:17869444\|RGD:10047215
Cellular Component	GO:0045202	synapse	Kcna1	IDA		Mouse	MGI:MGI:67695\|PMID:8046438
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNA1	IMP		Human	PMID:10585425
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNA1	IDA		Human	PMID:11086297
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna1	IDA		Mouse	MGI:MGI:5607246\|PMID:8361541
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna1	IMP		Rat	PMID:12177193\|RGD:10047355
Biological Process	GO:0061564	axon development	Kcna1	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0007420	brain development	Kcna1	IMP		Mouse	MGI:MGI:5297001\|PMID:21966978
Biological Process	GO:0010644	cell communication by electrical coupling	Kcna1	IMP		Rat	PMID:22206926\|RGD:10047237
Biological Process	GO:0071286	cellular response to magnesium ion	Kcna1	IMP		Mouse	MGI:MGI:5613458\|PMID:23903368
Biological Process	GO:0021987	cerebral cortex development	Kcna1	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0022038	corpus callosum development	Kcna1	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Kcna1	IMP		Mouse	MGI:MGI:5494919\|PMID:23473320
Biological Process	GO:0050976	detection of mechanical stimulus involved in sensory perception of touch	Kcna1	IMP		Mouse	MGI:MGI:5494919\|PMID:23473320
Biological Process	GO:0021766	hippocampus development	Kcna1	IMP		Mouse	MGI:MGI:5613474\|PMID:17315199
Biological Process	GO:0010960	magnesium ion homeostasis	KCNA1	IMP		Human	PMID:19307729
Biological Process	GO:0007405	neuroblast proliferation	Kcna1	IMP		Mouse	MGI:MGI:5613474\|PMID:17315199
Biological Process	GO:0050905	neuromuscular process	KCNA1	IMP		Human	PMID:17136396
Biological Process	GO:0050905	neuromuscular process	Kcna1	IMP		Mouse	MGI:MGI:2181308\|PMID:9736643
Biological Process	GO:0019228	neuronal action potential	Kcna1	IMP		Mouse	MGI:MGI:2181308\|PMID:9736643
Biological Process	GO:0019228	neuronal action potential	Kcna1	IMP		Rat	PMID:12177193\|RGD:10047355
Biological Process	GO:0019228	neuronal action potential	Kcna1	IMP		Rat	PMID:17869444\|RGD:10047215
Biological Process	GO:0023041	neuronal signal transduction	Kcna1	IMP		Rat	PMID:22206926\|RGD:10047237
Biological Process	GO:0021554	optic nerve development	Kcna1	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:1903818	positive regulation of voltage-gated potassium channel activity	Kcna1	IDA		Rat	PMID:21943416\|RGD:7242916
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNA1	IMP		Human	PMID:19912772
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna1	IDA		Mouse	MGI:MGI:5605952\|PMID:15361858
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna1	IDA		Rat	PMID:22206926\|RGD:10047237
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna1	IMP		Rat	PMID:2555158\|RGD:69870
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna1	IDA		Rat	PMID:8038169\|RGD:10047389
Biological Process	GO:0008104	protein localization	Kcna1	IDA		Rat	PMID:10896669\|RGD:10047332
Biological Process	GO:0042391	regulation of membrane potential	KCNA1	IMP		Human	PMID:19307729
Biological Process	GO:0006937	regulation of muscle contraction	Kcna1	IMP		Rat	PMID:22206926\|RGD:10047237
Biological Process	GO:0001964	startle response	Kcna1	IMP		Mouse	MGI:MGI:5297001\|PMID:21966978
Biological Process	GO:0001964	startle response	Kcna1	IMP		Rat	PMID:22206926\|RGD:10047237

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.