Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcna5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNA5
- Mouse genes Kcna5
- Rat genes Kcna5
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcna5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	KCNA5	IPI	UniProtKB:P35609	Human	PMID:10812072
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNA5	IDA		Human	PMID:12130714
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNA5	IMP		Human	PMID:19343045
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNA5	IDA		Human	PMID:1986382
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcna5	IDA		Rat	PMID:15618540\|RGD:10047274
Molecular Function	GO:0015271	outward rectifier potassium channel activity	KCNA5	IDA		Human	PMID:12970345
Molecular Function	GO:0015271	outward rectifier potassium channel activity	KCNA5	IMP		Human	PMID:16236819
Molecular Function	GO:0015271	outward rectifier potassium channel activity	Kcna5	IMP		Rat	PMID:12127166\|RGD:1581351
Molecular Function	GO:0015271	outward rectifier potassium channel activity	Kcna5	IMP		Rat	PMID:15930148\|RGD:1581348
Molecular Function	GO:0005515	protein binding	KCNA5	IPI	UniProtKB:P35609	Human	PMID:10812072
Molecular Function	GO:0005515	protein binding	KCNA5	IPI	UniProtKB:P35609	Human	PMID:11389904
Molecular Function	GO:0005515	protein binding	KCNA5	IPI	UniProtKB:Q14160	Human	PMID:24550280
Molecular Function	GO:0005515	protein binding	KCNA5	IPI	UniProtKB:Q6UX40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kcna5	IPI	UniProtKB:Q4U4S6	Mouse	MGI:MGI:6114554\|PMID:29306897
Molecular Function	GO:0005515	protein binding	Kcna5	IPI	PR:Q811D0	Mouse	PMID:15277200
Molecular Function	GO:0005515	protein binding	Kcna5	IPI	PR:P51637	Mouse	PMID:15277200
Molecular Function	GO:0005515	protein binding	Kcna5	IPI	PR:Q9D808	Mouse	PMID:18603586
Molecular Function	GO:0005515	protein binding	Kcna5	IPI	RGD:2280	Rat	PMID:16527989\|RGD:1582161
Molecular Function	GO:0019901	protein kinase binding	KCNA5	IPI	UniProtKB:P12931	Human	PMID:8953041
Molecular Function	GO:0097110	scaffold protein binding	KCNA5	IPI	UniProtKB:Q12959	Human	PMID:12970345
Molecular Function	GO:0097110	scaffold protein binding	KCNA5	IPI	UniProtKB:Q13642	Human	PMID:18281375
Molecular Function	GO:0005102	signaling receptor binding	Kcna5	IPI	RGD:61800	Rat	PMID:16527989\|RGD:1582161
Molecular Function	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	KCNA5	IMP		Human	PMID:19343045
Molecular Function	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	KCNA5	IMP		Human	PMID:23264583
Molecular Function	GO:0086087	voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	KCNA5	IMP		Human	PMID:23264583
Molecular Function	GO:0086090	voltage-gated potassium channel activity involved in SA node cell action potential repolarization	KCNA5	IMP		Human	PMID:19343045
Molecular Function	GO:0086090	voltage-gated potassium channel activity involved in SA node cell action potential repolarization	KCNA5	IMP		Human	PMID:23264583
Cellular Component	GO:0009986	cell surface	KCNA5	IDA		Human	PMID:23264583
Cellular Component	GO:0005783	endoplasmic reticulum	Kcna5	IDA		Rat	PMID:16185660\|RGD:7242767
Cellular Component	GO:0005794	Golgi apparatus	KCNA5	HDA		Human	PMID:16780588
Cellular Component	GO:0005794	Golgi apparatus	Kcna5	IDA		Rat	PMID:16185660\|RGD:7242767
Cellular Component	GO:0014704	intercalated disc	KCNA5	IDA		Human	PMID:7615797
Cellular Component	GO:0014704	intercalated disc	Kcna5	IDA		Mouse	PMID:18603586
Cellular Component	GO:0014704	intercalated disc	Kcna5	IDA		Rat	PMID:20357183\|RGD:7242751
Cellular Component	GO:0046691	intracellular canaliculus	Kcna5	IDA		Rat	PMID:17496801\|RGD:7242765
Cellular Component	GO:0016020	membrane	Kcna5	IDA		Mouse	PMID:18603586
Cellular Component	GO:0045121	membrane raft	KCNA5	IDA		Human	PMID:18218624
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Kcna5	IDA		Rat	PMID:17496801\|RGD:7242765
Cellular Component	GO:0005886	plasma membrane	KCNA5	IDA		Human	PMID:12130714
Cellular Component	GO:0005886	plasma membrane	KCNA5	HDA		Human	PMID:16780588
Cellular Component	GO:0005886	plasma membrane	KCNA5	IDA		Human	PMID:7615797
Cellular Component	GO:0005886	plasma membrane	Kcna5	IDA		Mouse	PMID:15277200
Cellular Component	GO:0005886	plasma membrane	Kcna5	IMP		Rat	PMID:15618540\|RGD:10047274
Cellular Component	GO:0005886	plasma membrane	Kcna5	IDA		Rat	PMID:17496801\|RGD:7242765
Cellular Component	GO:0034705	potassium channel complex	KCNA5	IDA		Human	PMID:12130714
Cellular Component	GO:0034705	potassium channel complex	Kcna5	IDA		Rat	PMID:9334400\|RGD:10047182
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNA5	IDA		Human	PMID:1986382
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNA5	IDA		Human	PMID:23264583
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcna5	IDA		Rat	PMID:15618540\|RGD:10047274
Cellular Component	GO:0030018	Z disc	Kcna5	IDA		Rat	PMID:17054951\|RGD:7242766
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	KCNA5	IMP		Human	PMID:19343045
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	KCNA5	IMP		Human	PMID:23264583
Biological Process	GO:0060081	membrane hyperpolarization	KCNA5	IMP		Human	PMID:16236819
Biological Process	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	KCNA5	IMP		Human	PMID:19343045
Biological Process	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	KCNA5	IMP		Human	PMID:23264583
Biological Process	GO:0086050	membrane repolarization during bundle of His cell action potential	KCNA5	IMP		Human	PMID:23264583
Biological Process	GO:0086052	membrane repolarization during SA node cell action potential	KCNA5	IMP		Human	PMID:19343045
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Kcna5	IMP		Rat	PMID:15151918\|RGD:1627657
Biological Process	GO:0007219	Notch signaling pathway	Kcna5	IDA		Mouse	PMID:23117660
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Kcna5	IDA		Rat	PMID:18230363\|RGD:7242757
Biological Process	GO:2000288	positive regulation of myoblast proliferation	Kcna5	IDA		Rat	PMID:18230363\|RGD:7242757
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNA5	IDA		Human	PMID:12970345
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNA5	IMP		Human	PMID:16236819
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNA5	IDA		Human	PMID:1986382
Biological Process	GO:0097623	potassium ion export across plasma membrane	Kcna5	IMP		Rat	PMID:12127166\|RGD:1581351
Biological Process	GO:0055075	potassium ion homeostasis	Kcna5	IMP		Rat	PMID:12127166\|RGD:1581351
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNA5	IDA		Human	PMID:12130714
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcna5	IDA		Rat	PMID:15618540\|RGD:10047274
Biological Process	GO:0006813	potassium ion transport	KCNA5	IDA		Human	PMID:8576199
Biological Process	GO:0051259	protein complex oligomerization	Kcna5	IMP		Rat	PMID:12127166\|RGD:1581351
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	KCNA5	IMP		Human	PMID:19343045
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNA5	IMP		Human	PMID:19343045
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNA5	IMP		Human	PMID:23264583
Biological Process	GO:0042391	regulation of membrane potential	KCNA5	IDA		Human	PMID:1986382
Biological Process	GO:0042391	regulation of membrane potential	Kcna5	IGI	MGI:MGI:107570	Mouse	PMID:15277200
Biological Process	GO:0042391	regulation of membrane potential	Kcna5	IGI	MGI:MGI:107231	Mouse	PMID:15277200
Biological Process	GO:0042391	regulation of membrane potential	Kcna5	IMP		Rat	PMID:18230363\|RGD:7242757
Biological Process	GO:0043266	regulation of potassium ion transport	KCNA5	IMP		Human	PMID:12021261
Biological Process	GO:0019229	regulation of vasoconstriction	Kcna5	IMP	MGI:MGI:2384510	Mouse	PMID:11481235
Biological Process	GO:0042542	response to hydrogen peroxide	Kcna5	IEP		Rat	PMID:16735674\|RGD:8693740
Biological Process	GO:0055093	response to hyperoxia	Kcna5	IEP		Rat	PMID:16735674\|RGD:8693740
Biological Process	GO:0001666	response to hypoxia	Kcna5	IEP		Rat	PMID:15151918\|RGD:1627657
Biological Process	GO:0009612	response to mechanical stimulus	Kcna5	IEP		Rat	PMID:17293496\|RGD:7247436
Biological Process	GO:0010033	response to organic substance	Kcna5	IEP		Rat	PMID:16735674\|RGD:8693740

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.