Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNAB1
  • Mouse genes Kcnab1
  • Rat genes Kcnab1
  • Zfish genes kcnab1a,kcnab1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnab1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	Kcnab1	IDA		Rat	PMID:18222921|RGD:10047381
Molecular Function	GO:0140678	molecular function inhibitor activity	KCNAB1	IDA		Human	PMID:10585425
Molecular Function	GO:0070402	NADPH binding	KCNAB1	IDA		Human	PMID:17540341
Molecular Function	GO:0015459	potassium channel regulator activity	KCNAB1	IDA		Human	PMID:12130714
Molecular Function	GO:0015459	potassium channel regulator activity	KCNAB1	IDA		Human	PMID:7890032
Molecular Function	GO:0015459	potassium channel regulator activity	Kcnab1	IDA		Rat	PMID:18222921|RGD:10047381
Molecular Function	GO:0015459	potassium channel regulator activity	Kcnab1	IDA		Rat	PMID:8183366|RGD:61642
Molecular Function	GO:0005515	protein binding	Kcnab1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:25707359
Molecular Function	GO:0005515	protein binding	Kcnab1	IPI	PR:Q9Z0V2	Mouse	PMID:15662035
Molecular Function	GO:0005515	protein binding	Kcnab1	IPI	UniProtKB:P10499	Rat	PMID:10585425|RGD:153298938
Molecular Function	GO:0005515	protein binding	Kcnab1	IPI	UniProtKB:Q8K4Y5	Rat	PMID:16504945|RGD:8554700
Molecular Function	GO:0019904	protein domain specific binding	KCNAB1	IPI	UniProtKB:Q09470	Human	PMID:10585425
Molecular Function	GO:0044325	transmembrane transporter binding	Kcnab1	IPI	RGD:2950	Rat	PMID:8756417|RGD:9743934
Molecular Function	GO:0044325	transmembrane transporter binding	Kcnab1	IPI	RGD:61828	Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0030424	axon	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0005829	cytosol	KCNAB1	IDA		Human	PMID:17540341
Cellular Component	GO:0032839	dendrite cytoplasm	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	KCNAB1	IDA		Human	PMID:17540341
Cellular Component	GO:0044224	juxtaparanode region of axon	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0016020	membrane	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0043025	neuronal cell body	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0043204	perikaryon	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0005886	plasma membrane	Kcnab1	IDA		Rat	PMID:8938716|RGD:9743937
Cellular Component	GO:0034705	potassium channel complex	KCNAB1	IDA		Human	PMID:12130714
Cellular Component	GO:0034705	potassium channel complex	Kcnab1	IDA		Rat	PMID:9334400|RGD:10047182
Cellular Component	GO:1990635	proximal dendrite	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNAB1	IMP		Human	PMID:10585425
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcnab1	IDA		Rat	PMID:8756417|RGD:9743934
Biological Process	GO:0007420	brain development	Kcnab1	IEP		Rat	PMID:12652645|RGD:9743957
Biological Process	GO:0060539	diaphragm development	Kcnab1	IEP		Rat	PMID:12652645|RGD:9743957
Biological Process	GO:0007507	heart development	Kcnab1	IEP		Rat	PMID:12652645|RGD:9743957
Biological Process	GO:0007611	learning or memory	Kcnab1	IMP	MGI:MGI:2181771	Mouse	PMID:14511342
Biological Process	GO:0045445	myoblast differentiation	Kcnab1	IEP		Rat	PMID:12652645|RGD:9743957
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	Kcnab1	IDA		Rat	PMID:8183366|RGD:61642
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	Kcnab1	IMP		Rat	PMID:8799886|RGD:9743956
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	KCNAB1	IMP		Human	PMID:10585425
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	Kcnab1	IDA		Rat	PMID:18222921|RGD:10047381
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	Kcnab1	IDA		Rat	PMID:8183366|RGD:61642
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	KCNAB1	IDA		Human	PMID:7890032
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	Kcnab1	IMP	MGI:MGI:3621902	Mouse	PMID:15662035
Biological Process	GO:0007519	skeletal muscle tissue development	Kcnab1	IEP		Rat	PMID:12652645|RGD:9743957

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern