Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNC4
  • Mouse genes Kcnc4
  • Rat genes Kcnc4
  • Zfish genes kcnc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KCNC4	IPI	UniProtKB:P56817	Human	PMID:29507146
Molecular Function	GO:0005515	protein binding	Kcnc4	IPI	RGD:2955	Rat	PMID:21943417|RGD:12910700
Molecular Function	GO:0005515	protein binding	Kcnc4	IPI	RGD:2956	Rat	PMID:21943417|RGD:12910700
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Kcnc4	IDA		Rat	PMID:12592408|RGD:13702380
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Kcnc4	IMP		Rat	PMID:12592408|RGD:13702380
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcnc4	IDA		Rat	PMID:12592408|RGD:13702380
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcnc4	IMP		Rat	PMID:12592408|RGD:13702380
Cellular Component	GO:0030424	axon	Kcnc4	IDA		Rat	PMID:22473424|RGD:10411906
Cellular Component	GO:0043679	axon terminus	Kcnc4	IDA		Mouse	PMID:15610163
Cellular Component	GO:0044305	calyx of Held	Kcnc4	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0009986	cell surface	Kcnc4	IDA		Rat	PMID:21943416|RGD:7242916
Cellular Component	GO:0030425	dendrite	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0005783	endoplasmic reticulum	Kcnc4	IDA		Rat	PMID:21943416|RGD:7242916
Cellular Component	GO:0098978	glutamatergic synapse	Kcnc4	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0098978	glutamatergic synapse	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0098690	glycinergic synapse	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0005794	Golgi apparatus	Kcnc4	IDA		Rat	PMID:21943416|RGD:7242916
Cellular Component	GO:0031594	neuromuscular junction	Kcnc4	IDA		Mouse	PMID:15610163
Cellular Component	GO:0043025	neuronal cell body	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0043025	neuronal cell body	Kcnc4	IDA		Rat	PMID:22473424|RGD:10411906
Cellular Component	GO:0005886	plasma membrane	Kcnc4	IDA		Rat	PMID:15161842|RGD:10411909
Cellular Component	GO:0098794	postsynapse	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0045211	postsynaptic membrane	Kcnc4	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0045211	postsynaptic membrane	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0042734	presynaptic membrane	Kcnc4	IDA		Rat	PMID:14614103|RGD:13702408
Cellular Component	GO:0042734	presynaptic membrane	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Cellular Component	GO:0008021	synaptic vesicle	Kcnc4	IDA		Rat	PMID:15207333|RGD:10411903
Biological Process	GO:0061564	axon development	Kcnc4	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0021987	cerebral cortex development	Kcnc4	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0022038	corpus callosum development	Kcnc4	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0030900	forebrain development	Kcnc4	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:1904456	negative regulation of neuronal action potential	Kcnc4	IMP		Rat	PMID:18048010|RGD:10412022
Biological Process	GO:1904057	negative regulation of sensory perception of pain	Kcnc4	IMP		Rat	PMID:17855600|RGD:10411908
Biological Process	GO:0021554	optic nerve development	Kcnc4	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Kcnc4	IMP		Mouse	PMID:15610163

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern