Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNE3
  • Mouse genes Kcne3
  • Rat genes Kcne3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcne3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015459	potassium channel regulator activity	KCNE3	IDA		Human	PMID:12954870
Molecular Function	GO:0015459	potassium channel regulator activity	Kcne3	IDA		Rat	PMID:11426298|RGD:633042
Molecular Function	GO:0015459	potassium channel regulator activity	Kcne3	IDA		Rat	PMID:12954870|RGD:10047250
Molecular Function	GO:0005515	protein binding	KCNE3	IPI	UniProtKB:P51787	Human	PMID:20533308
Molecular Function	GO:0005515	protein binding	Kcne3	IPI	UniProtKB:Q9Z0N7	Rat	PMID:21911611|RGD:10412297
Molecular Function	GO:0044325	transmembrane transporter binding	Kcne3	IPI	UniProtKB:P15387	Rat	PMID:12954870|RGD:10047250
Molecular Function	GO:0044325	transmembrane transporter binding	Kcne3	IPI	UniProtKB:P25122	Rat	PMID:12954870|RGD:10047250
Cellular Component	GO:1990794	basolateral part of cell	Kcne3	IDA		Mouse	PMID:11527966
Cellular Component	GO:0005737	cytoplasm	KCNE3	IDA		Human	PMID:12954870
Cellular Component	GO:0030425	dendrite	KCNE3	IDA		Human	PMID:12954870
Cellular Component	GO:0045121	membrane raft	KCNE3	IDA		Human	PMID:20533308
Cellular Component	GO:0032809	neuronal cell body membrane	KCNE3	IDA		Human	PMID:12954870
Cellular Component	GO:0043204	perikaryon	KCNE3	IDA		Human	PMID:12954870
Cellular Component	GO:0005886	plasma membrane	KCNE3	IPI	UniProtKB:P51787	Human	PMID:10646604
Cellular Component	GO:0005886	plasma membrane	KCNE3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Kcne3	IDA		Rat	PMID:12954870|RGD:10047250
Cellular Component	GO:0031982	vesicle	KCNE3	IDA		Human	PMID:10646604
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Kcne3	IDA		Mouse	PMID:11527966
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Kcne3	IMP		Mouse	PMID:11527966
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	KCNE3	IDA		Human	PMID:12954870
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	Kcne3	IDA		Rat	PMID:12954870|RGD:10047250
Biological Process	GO:1905025	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential	KCNE3	IMP		Human	PMID:22987075
Biological Process	GO:1903765	negative regulation of potassium ion export across plasma membrane	KCNE3	IDA		Human	PMID:22987075
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	KCNE3	IDA		Human	PMID:22987075
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	Kcne3	IDA		Rat	PMID:14679187|RGD:7243967
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	Kcne3	IDA		Rat	PMID:14679187|RGD:7243967
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcne3	IMP		Mouse	PMID:11527966
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcne3	IDA		Mouse	PMID:11527966
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNE3	IMP		Human	PMID:22987075
Biological Process	GO:0043266	regulation of potassium ion transport	Kcne3	IMP		Rat	PMID:11426298|RGD:633042
Biological Process	GO:0006814	sodium ion transport	Kcne3	IDA		Mouse	PMID:11527966
Biological Process	GO:0006814	sodium ion transport	Kcne3	IMP		Mouse	PMID:11527966

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern