Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcnh1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNH1
- Mouse genes Kcnh1
- Rat genes Kcnh1
- Zfish genes kcnh1a,kcnh1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Kcnh1	IPI	RGD:3979	Rat	PMID:22911758\|RGD:9693692
Molecular Function	GO:0005516	calmodulin binding	Kcnh1	IDA		Rat	PMID:27516594\|RGD:11533419
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNH1	IDA		Human	PMID:22732247
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNH1	IDA		Human	PMID:27005320
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNH1	IDA		Human	PMID:27325704
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcnh1	IDA		Mouse	MGI:MGI:5616314\|PMID:19671703
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcnh1	IDA		Rat	PMID:27516594\|RGD:11533419
Molecular Function	GO:0042802	identical protein binding	Kcnh1	IDA		Rat	PMID:21646358\|RGD:9693690
Molecular Function	GO:1902936	phosphatidylinositol bisphosphate binding	KCNH1	IDA		Human	PMID:27005320
Molecular Function	GO:0005515	protein binding	KCNH1	IPI	UniProtKB:P02638	Human	PMID:20708613
Molecular Function	GO:0005515	protein binding	KCNH1	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KCNH1	IPI	UniProtKB:Q7L8L6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KCNH1	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Kcnh1	IPI	RGD:619772	Rat	PMID:10559257\|RGD:9693722
Molecular Function	GO:0005515	protein binding	Kcnh1	IPI	UniProtKB:O35550	Rat	PMID:22841712\|RGD:8553845
Molecular Function	GO:0005515	protein binding	Kcnh1	IPI	RGD:708500	Rat	PMID:9722534\|RGD:1299478
Molecular Function	GO:0019901	protein kinase binding	Kcnh1	IPI	RGD:620795	Rat	PMID:11834728\|RGD:634207
Molecular Function	GO:0044877	protein-containing complex binding	Kcnh1	IPI	RGD:621417	Rat	PMID:25008323\|RGD:9693717
Molecular Function	GO:0044325	transmembrane transporter binding	Kcnh1	IPI	RGD:621417	Rat	PMID:25008323\|RGD:9693717
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcnh1	IMP		Mouse	PMID:25556795
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Kcnh1	IDA		Mouse	PMID:25556795
Molecular Function	GO:0005249	voltage-gated potassium channel activity	kcnh1a	IDA		Zfish	PMID:22927438
Molecular Function	GO:0005249	voltage-gated potassium channel activity	kcnh1b	IDA		Zfish	PMID:22927438
Cellular Component	GO:0030673	axolemma	Kcnh1	IDA		Rat	PMID:20111597\|RGD:9693719
Cellular Component	GO:0030424	axon	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Cellular Component	GO:0009986	cell surface	Kcnh1	IDA		Rat	PMID:21646358\|RGD:9693690
Cellular Component	GO:0030425	dendrite	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Cellular Component	GO:0031901	early endosome membrane	KCNH1	IDA		Human	PMID:22841712
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KCNH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Cellular Component	GO:0005637	nuclear inner membrane	Kcnh1	IDA		Rat	PMID:21559285\|RGD:9693693
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Kcnh1	IDA		Mouse	PMID:25556795
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Kcnh1	IMP		Mouse	PMID:25556795
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Kcnh1	IDA		Rat	PMID:18650019\|RGD:9693716
Cellular Component	GO:0005886	plasma membrane	KCNH1	IMP		Human	PMID:22732247
Cellular Component	GO:0005886	plasma membrane	KCNH1	IDA		Human	PMID:27005320
Cellular Component	GO:0005886	plasma membrane	KCNH1	IDA		Human	PMID:27325704
Cellular Component	GO:0005886	plasma membrane	Kcnh1	IDA		Mouse	MGI:MGI:5616314\|PMID:19671703
Cellular Component	GO:0005886	plasma membrane	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Cellular Component	GO:0005886	plasma membrane	Kcnh1	IDA		Rat	PMID:27516594\|RGD:11533419
Cellular Component	GO:0034705	potassium channel complex	Kcnh1	IDA		Rat	PMID:27516594\|RGD:11533419
Cellular Component	GO:0042734	presynaptic membrane	Kcnh1	IDA		Rat	PMID:25556795\|RGD:13702416
Cellular Component	GO:0042734	presynaptic membrane	Kcnh1	IDA		Rat	PMID:20111597\|RGD:9693719
Cellular Component	GO:0045202	synapse	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNH1	IDA		Human	PMID:22732247
Biological Process	GO:0071277	cellular response to calcium ion	KCNH1	IMP		Human	PMID:27005320
Biological Process	GO:0071277	cellular response to calcium ion	KCNH1	IMP		Human	PMID:27325704
Biological Process	GO:0071277	cellular response to calcium ion	Kcnh1	IDA		Rat	PMID:27516594\|RGD:11533419
Biological Process	GO:0071277	cellular response to calcium ion	Kcnh1	IDA		Rat	PMID:8790430\|RGD:9693720
Biological Process	GO:0043009	chordate embryonic development	kcnh1a	IMP	ZFIN:ZDB-MRPHLNO-121127-4	Zfish	PMID:22927438
Biological Process	GO:0043009	chordate embryonic development	kcnh1b	IMP	ZFIN:ZDB-MRPHLNO-121128-6	Zfish	PMID:22927438
Biological Process	GO:0021576	hindbrain formation	kcnh1a	IMP	ZFIN:ZDB-MRPHLNO-121127-4	Zfish	PMID:22927438
Biological Process	GO:0021576	hindbrain formation	kcnh1b	IMP	ZFIN:ZDB-MRPHLNO-121128-6	Zfish	PMID:22927438
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Kcnh1	IDA		Rat	PMID:24495567\|RGD:9693685
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	KCNH1	IMP		Human	PMID:27005320
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH1	IDA		Human	PMID:22732247
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH1	IDA		Human	PMID:27005320
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH1	IDA		Human	PMID:27325704
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnh1	IDA		Mouse	MGI:MGI:5616314\|PMID:19671703
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnh1	IDA		Rat	PMID:7925287\|RGD:68271
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnh1	IDA		Rat	PMID:9722534\|RGD:1299478
Biological Process	GO:0042127	regulation of cell population proliferation	KCNH1	IMP		Human	PMID:23881642
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Kcnh1	IDA		Mouse	PMID:25556795
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Kcnh1	IMP		Mouse	PMID:25556795
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Kcnh1	IMP		Mouse	PMID:25556795
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Kcnh1	IDA		Mouse	PMID:25556795
Biological Process	GO:0001756	somitogenesis	kcnh1a	IMP	ZFIN:ZDB-MRPHLNO-121127-4	Zfish	PMID:22927438
Biological Process	GO:0001756	somitogenesis	kcnh1b	IMP	ZFIN:ZDB-MRPHLNO-121128-6	Zfish	PMID:22927438
Biological Process	GO:0001964	startle response	Kcnh1	IMP		Rat	PMID:24284010\|RGD:9693684

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.