Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNH2
  • Mouse genes Kcnh2
  • Rat genes Kcnh2
  • Zfish genes kcnh2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	KCNH2	IPI	UniProtKB:Q6ZRF8	Human	PMID:25281747
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNH2	IGI	UniProtKB:Q6ZRF8	Human	PMID:25281747
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNH2	IDA		Human	PMID:7736582
Molecular Function	GO:0042802	identical protein binding	KCNH2	IPI	UniProtKB:Q12809	Human	PMID:24931372
Molecular Function	GO:0042802	identical protein binding	KCNH2	IPI	UniProtKB:Q12809	Human	PMID:8995352
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNH2	IMP		Human	PMID:14525949
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNH2	IDA		Human	PMID:7604285
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNH2	IDA		Human	PMID:8587608
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnh2	IDA		Mouse	PMID:9351462
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnh2	IDA		Rat	PMID:15677682|RGD:1580505
Molecular Function	GO:0005216	monoatomic ion channel activity	Kcnh2	IDA		Rat	PMID:11804849|RGD:625508
Molecular Function	GO:0005267	potassium channel activity	Kcnh2	IDA		Rat	PMID:11804849|RGD:625508
Molecular Function	GO:0005515	protein binding	KCNH2	IPI	UniProtKB:P62258	Human	PMID:11953308
Molecular Function	GO:0005515	protein binding	KCNH2	IPI	UniProtKB:Q04917	Human	PMID:11953308
Molecular Function	GO:0005515	protein binding	KCNH2	IPI	UniProtKB:P27824	Human	PMID:16361248
Molecular Function	GO:0005515	protein binding	KCNH2	IPI	UniProtKB:Q03135	Human	PMID:18923542
Molecular Function	GO:0005515	protein binding	Kcnh2	IPI	UniProtKB:P51638	Rat	PMID:22879586|RGD:8553349
Molecular Function	GO:0042803	protein homodimerization activity	KCNH2	IPI	UniProtKB:Q12809	Human	PMID:8995352
Molecular Function	GO:0044877	protein-containing complex binding	Kcnh2	IDA		Rat	PMID:11212207|RGD:2314395
Molecular Function	GO:0097110	scaffold protein binding	KCNH2	IPI	UniProtKB:Q03135	Human	PMID:18923542
Molecular Function	GO:0097110	scaffold protein binding	Kcnh2	IPI	UniProtKB:P41350	Rat	PMID:18923542|RGD:10047293
Molecular Function	GO:0000976	transcription cis-regulatory region binding	KCNH2	IDA		Human	PMID:31146003
Molecular Function	GO:0031625	ubiquitin protein ligase binding	KCNH2	IPI	UniProtKB:Q96PU5	Human	PMID:21463633
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNH2	IDA		Human	PMID:11953308
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNH2	IDA		Human	PMID:21063088
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNH2	IDA		Human	PMID:28280240
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnh2	IDA		Mouse	PMID:9351446
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnh2	IDA		Rat	PMID:15677682|RGD:1580505
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCNH2	IMP		Human	PMID:21536673
Cellular Component	GO:0009986	cell surface	KCNH2	IDA		Human	PMID:21536673
Cellular Component	GO:1902937	inward rectifier potassium channel complex	KCNH2	IMP		Human	PMID:14525949
Cellular Component	GO:0048471	perinuclear region of cytoplasm	KCNH2	IMP		Human	PMID:25281747
Cellular Component	GO:0005886	plasma membrane	KCNH2	IDA		Human	PMID:21463633
Cellular Component	GO:0005886	plasma membrane	KCNH2	IMP		Human	PMID:25281747
Cellular Component	GO:0005886	plasma membrane	Kcnh2	IDA		Rat	PMID:11804849|RGD:625508
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNH2	IMP		Human	PMID:25281747
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNH2	IDA		Human	PMID:7604285
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNH2	IDA		Human	PMID:7736582
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:0007420	brain development	Kcnh2	IEP		Rat	PMID:15365256|RGD:7243961
Biological Process	GO:0060048	cardiac muscle contraction	KCNH2	IMP		Human	PMID:21536673
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0086010	membrane depolarization during action potential	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0086009	membrane repolarization	KCNH2	IMP		Human	PMID:14525949
Biological Process	GO:0086011	membrane repolarization during action potential	KCNH2	IDA		Human	PMID:11953308
Biological Process	GO:0086011	membrane repolarization during action potential	KCNH2	IDA		Human	PMID:21463633
Biological Process	GO:0086011	membrane repolarization during action potential	KCNH2	IDA		Human	PMID:7736582
Biological Process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	KCNH2	IMP		Human	PMID:21536673
Biological Process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	KCNH2	IMP		Human	PMID:21536673
Biological Process	GO:0106057	negative regulation of calcineurin-mediated signaling	kcnh2a	IMP	ZFIN:ZDB-GENO-230124-3	Zfish	PMID:34061172
Biological Process	GO:1903765	negative regulation of potassium ion export across plasma membrane	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:1903765	negative regulation of potassium ion export across plasma membrane	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KCNH2	IMP		Human	PMID:31146003
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:7736582
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNH2	IGI	UniProtKB:Q6ZRF8	Human	PMID:25281747
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0055075	potassium ion homeostasis	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0055075	potassium ion homeostasis	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:1990573	potassium ion import across plasma membrane	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:11953308
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:21063088
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:7604285
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:7736582
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnh2	IDA		Mouse	PMID:9351462
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnh2	IDA		Mouse	PMID:9351446
Biological Process	GO:0006813	potassium ion transport	Kcnh2	IDA		Rat	PMID:9390998|RGD:632747
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNH2	IMP		Human	PMID:7889573
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNH2	IMP		Human	PMID:21536673
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Kcnh2	IDA		Mouse	PMID:10843886
Biological Process	GO:0042391	regulation of membrane potential	KCNH2	IDA		Human	PMID:21463633
Biological Process	GO:0042391	regulation of membrane potential	KCNH2	IDA		Human	PMID:8587608
Biological Process	GO:0042391	regulation of membrane potential	Kcnh2	IDA		Mouse	PMID:9351446
Biological Process	GO:0042391	regulation of membrane potential	Kcnh2	IDA		Mouse	PMID:9351462
Biological Process	GO:0042391	regulation of membrane potential	Kcnh2	IDA		Rat	PMID:11804849|RGD:625508
Biological Process	GO:0060306	regulation of membrane repolarization	KCNH2	IDA		Human	PMID:21463633
Biological Process	GO:0060306	regulation of membrane repolarization	KCNH2	IDA		Human	PMID:7736582
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	KCNH2	IDA		Human	PMID:11953308
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	KCNH2	IMP		Human	PMID:21536673
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Kcnh2	IDA		Mouse	PMID:10843886
Biological Process	GO:0021510	spinal cord development	Kcnh2	IEP		Rat	PMID:15365256|RGD:7243961
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	KCNH2	IMP		Human	PMID:21536673

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern