Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNH6
  • Mouse genes Kcnh6
  • Rat genes Kcnh6
  • Zfish genes kcnh6a,kcnh6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnh6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnh6	IDA		Rat	PMID:15677682|RGD:1580505
Molecular Function	GO:0005216	monoatomic ion channel activity	kcnh6a	IMP		Zfish	PMID:17592134
Molecular Function	GO:0005216	monoatomic ion channel activity	kcnh6a	IDA		Zfish	PMID:17592134
Molecular Function	GO:0044877	protein-containing complex binding	Kcnh6	IDA		Rat	PMID:11212207|RGD:2314395
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnh6	IDA		Rat	PMID:15677682|RGD:1580505
Molecular Function	GO:0005249	voltage-gated potassium channel activity	kcnh6a	IDA		Zfish	PMID:19232322
Molecular Function	GO:0005249	voltage-gated potassium channel activity	kcnh6a	IDA		Zfish	PMID:18250272
Cellular Component	GO:0005886	plasma membrane	Kcnh6	IDA		Rat	PMID:11804849|RGD:625508
Biological Process	GO:0060047	heart contraction	kcnh6a	IMP	ZFIN:ZDB-MRPHLNO-070805-1	Zfish	PMID:24311987
Biological Process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	kcnh6a	IMP	ZFIN:ZDB-MRPHLNO-070805-1	Zfish	PMID:23303164
Biological Process	GO:0071805	potassium ion transmembrane transport	kcnh6a	IDA		Zfish	PMID:18250272|ZFIN:ZDB-PUB-080309-4
Biological Process	GO:0006813	potassium ion transport	Kcnh6	IDA		Rat	PMID:9390998|RGD:632747
Biological Process	GO:0008016	regulation of heart contraction	kcnh6a	IMP	ZFIN:ZDB-GENO-081010-2	Zfish	PMID:18250272
Biological Process	GO:0008016	regulation of heart contraction	kcnh6a	IMP	ZFIN:ZDB-GENO-070808-14	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	kcnh6a	IMP	ZFIN:ZDB-GENO-980202-856	Zfish	PMID:14678746
Biological Process	GO:0008016	regulation of heart contraction	kcnh6a	IMP	ZFIN:ZDB-MRPHLNO-071108-1	Zfish	PMID:20339120
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	kcnh6a	IMP	ZFIN:ZDB-GENO-070808-14	Zfish	PMID:21458413

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern