Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcnj11

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNJ11
- Mouse genes Kcnj11
- Rat genes Kcnj11
- Zfish genes kcnj11
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnj11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030506	ankyrin binding	KCNJ11	IPI	UniProtKB:Q01484	Human	PMID:20610380
Molecular Function	GO:0030506	ankyrin binding	Kcnj11	IPI	UniProtKB:Q8C8R3	Mouse	MGI:MGI:4844023\|PMID:20610380
Molecular Function	GO:0030506	ankyrin binding	Kcnj11	IPI	UniProtKB:F1LM42	Rat	PMID:19805355\|RGD:8554464
Molecular Function	GO:0005524	ATP binding	Kcnj11	IDA		Mouse	MGI:MGI:3793928\|PMID:12860923
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	Kcnj11	IDA		Mouse	MGI:MGI:3793935\|PMID:8630239
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	Kcnj11	IMP		Rat	PMID:15163199\|RGD:1598646
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	Kcnj11	IDA		Rat	PMID:17097686\|RGD:1625274
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	Kcnj11	IGI	UniProtKB:A0A1S4NYG1,UniProtKB:A0A1U7R319	Rat	PMID:28842488\|RGD:14995313
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	Kcnj11	IGI	UniProtKB:Q63563	Rat	PMID:28842488\|RGD:14995313
Molecular Function	GO:0019855	calcium channel inhibitor activity	Kcnj11	IMP		Mouse	PMID:33196462
Molecular Function	GO:0019855	calcium channel inhibitor activity	Kcnj11	IDA		Mouse	PMID:7502040
Molecular Function	GO:0019855	calcium channel inhibitor activity	Kcnj11	IMP	MGI:MGI:2178821	Mouse	PMID:16924481
Molecular Function	GO:0031072	heat shock protein binding	Kcnj11	IPI	RGD:1303075	Rat	PMID:20427569\|RGD:5686755
Molecular Function	GO:0031072	heat shock protein binding	Kcnj11	IPI	RGD:631409	Rat	PMID:20427569\|RGD:5686755
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnj11	IMP	MGI:MGI:2178821	Mouse	PMID:16924481
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnj11	IMP		Mouse	PMID:33196462
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnj11	IDA		Mouse	PMID:7502040
Molecular Function	GO:0005515	protein binding	KCNJ11	IPI	UniProtKB:Q01484	Human	PMID:19805355
Molecular Function	GO:0005515	protein binding	KCNJ11	IPI	UniProtKB:Q09428-1	Human	PMID:19805355
Molecular Function	GO:0005515	protein binding	KCNJ11	IPI	UniProtKB:Q96B26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	UniProtKB:G3I1T3	Mouse	MGI:MGI:5688851\|PMID:9488482
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	UniProtKB:Q8C8R3	Mouse	MGI:MGI:4361760\|PMID:19805355
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	UniProtKB:O94973	Mouse	MGI:MGI:5508626\|PMID:16902404
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	PR:Q8C8R3	Mouse	PMID:20610380
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	RGD:2048\|RGD:2281	Rat	PMID:19181933\|RGD:7297041
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	RGD:2281	Rat	PMID:20332621\|RGD:7296942
Molecular Function	GO:0005515	protein binding	Kcnj11	IPI	RGD:1306533\|RGD:620412	Rat	PMID:23066018\|RGD:7296922
Molecular Function	GO:0044325	transmembrane transporter binding	KCNJ11	IPI	UniProtKB:O60706	Human	PMID:20610380
Molecular Function	GO:0044325	transmembrane transporter binding	KCNJ11	IPI	UniProtKB:Q09428	Human	PMID:20610380
Molecular Function	GO:0044325	transmembrane transporter binding	Kcnj11	IPI	RGD:728331	Rat	PMID:14672537\|RGD:1598642
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNJ11	IDA		Human	PMID:18945825
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNJ11	IMP		Human	PMID:18945825
Molecular Function	GO:0005249	voltage-gated potassium channel activity	KCNJ11	IDA		Human	PMID:19805355
Cellular Component	GO:0001669	acrosomal vesicle	Kcnj11	IDA		Rat	PMID:21328565\|RGD:12792002
Cellular Component	GO:0030673	axolemma	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0070852	cell body fiber	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0005829	cytosol	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0005783	endoplasmic reticulum	Kcnj11	IDA		Rat	PMID:15983113\|RGD:1625265
Cellular Component	GO:0005768	endosome	Kcnj11	IDA		Rat	PMID:20971764\|RGD:7296940
Cellular Component	GO:0098978	glutamatergic synapse	Kcnj11	IDA		Rat	PMID:17883401\|RGD:155230746
Cellular Component	GO:0014704	intercalated disc	Kcnj11	IDA		Rat	PMID:23066018\|RGD:7296922
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Kcnj11	IDA		Rat	PMID:15983113\|RGD:1625265
Cellular Component	GO:0008282	inward rectifying potassium channel	KCNJ11	IPI		Human	PMID:29286281
Cellular Component	GO:0008282	inward rectifying potassium channel	KCNJ11	IDA		Human	PMID:19805355
Cellular Component	GO:0008282	inward rectifying potassium channel	KCNJ11	IDA		Human	PMID:20610380
Cellular Component	GO:0008282	inward rectifying potassium channel	Kcnj11	IDA		Mouse	MGI:MGI:3793935\|PMID:8630239
Cellular Component	GO:0008282	inward rectifying potassium channel	Kcnj11	IDA		Rat	PMID:17097686\|RGD:1625274
Cellular Component	GO:0005739	mitochondrion	Kcnj11	IDA		Rat	PMID:15983113\|RGD:1625265
Cellular Component	GO:0005739	mitochondrion	Kcnj11	IDA		Rat	PMID:16050978\|RGD:1598643
Cellular Component	GO:0043209	myelin sheath	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0043025	neuronal cell body	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0005635	nuclear envelope	Kcnj11	IDA		Rat	PMID:20102598\|RGD:7296980
Cellular Component	GO:0005886	plasma membrane	KCNJ11	IDA		Human	PMID:19805355
Cellular Component	GO:0005886	plasma membrane	Kcnj11	IDA		Mouse	PMID:16924481
Cellular Component	GO:0005886	plasma membrane	Kcnj11	IDA		Mouse	PMID:7502040
Cellular Component	GO:0005886	plasma membrane	Kcnj11	IDA		Mouse	PMID:16085792
Cellular Component	GO:0005886	plasma membrane	Kcnj11	IDA		Rat	PMID:15983113\|RGD:1625265
Cellular Component	GO:0042734	presynaptic membrane	Kcnj11	IDA		Rat	PMID:17883401\|RGD:155230746
Cellular Component	GO:0042383	sarcolemma	Kcnj11	IDA		Rat	PMID:12738227\|RGD:1598649
Cellular Component	GO:0042383	sarcolemma	Kcnj11	IDA		Rat	PMID:20971764\|RGD:7296940
Cellular Component	GO:0030315	T-tubule	Kcnj11	IDA		Mouse	PMID:20610380
Cellular Component	GO:0030315	T-tubule	Kcnj11	IDA		Rat	PMID:15647111\|RGD:1598637
Biological Process	GO:0071333	cellular response to glucose stimulus	Kcnj11	IEP		Rat	PMID:19720793\|RGD:7296981
Biological Process	GO:0071316	cellular response to nicotine	Kcnj11	IEP		Rat	PMID:22403787\|RGD:7296928
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Kcnj11	IEP		Rat	PMID:19460779\|RGD:7296986
Biological Process	GO:0031018	endocrine pancreas development	kcnj11	IMP	ZFIN:ZDB-CRISPR-160729-23	Zfish	PMID:26963759
Biological Process	GO:0031018	endocrine pancreas development	kcnj11	IMP	ZFIN:ZDB-MRPHLNO-160621-43	Zfish	PMID:26963759
Biological Process	GO:0006006	glucose metabolic process	KCNJ11	IMP		Human	PMID:15115830
Biological Process	GO:0006006	glucose metabolic process	KCNJ11	IMP		Human	PMID:8923010
Biological Process	GO:0098662	inorganic cation transmembrane transport	Kcnj11	IGI	UniProtKB:A0A1S4NYG1,UniProtKB:A0A1U7R319	Rat	PMID:28842488\|RGD:14995313
Biological Process	GO:0098662	inorganic cation transmembrane transport	Kcnj11	IGI	UniProtKB:Q63563	Rat	PMID:28842488\|RGD:14995313
Biological Process	GO:0046676	negative regulation of insulin secretion	KCNJ11	IMP		Human	PMID:8923010
Biological Process	GO:0046676	negative regulation of insulin secretion	Kcnj11	IMP	MGI:MGI:2178821	Mouse	PMID:16924481
Biological Process	GO:0046676	negative regulation of insulin secretion	Kcnj11	IMP		Mouse	PMID:33196462
Biological Process	GO:0050877	nervous system process	KCNJ11	IMP		Human	PMID:15115830
Biological Process	GO:0050877	nervous system process	KCNJ11	IMP		Human	PMID:18073297
Biological Process	GO:2001259	positive regulation of cation channel activity	Kcnj11	IMP		Rat	PMID:23785408\|RGD:7296920
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Kcnj11	IMP		Rat	PMID:23695995\|RGD:12790975
Biological Process	GO:1990573	potassium ion import across plasma membrane	Kcnj11	IDA		Mouse	MGI:MGI:3793935\|PMID:8630239
Biological Process	GO:1990573	potassium ion import across plasma membrane	Kcnj11	IDA		Rat	PMID:8630239\|RGD:8554593
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNJ11	IDA		Human	PMID:19805355
Biological Process	GO:0006813	potassium ion transport	Kcnj11	IMP		Rat	PMID:16048905\|RGD:1625261
Biological Process	GO:0006813	potassium ion transport	Kcnj11	IDA		Rat	PMID:17097686\|RGD:1625274
Biological Process	GO:0050796	regulation of insulin secretion	KCNJ11	IMP		Human	PMID:15115830
Biological Process	GO:0042391	regulation of membrane potential	KCNJ11	IDA		Human	PMID:18073297
Biological Process	GO:0033198	response to ATP	KCNJ11	IDA		Human	PMID:15583126
Biological Process	GO:0033198	response to ATP	KCNJ11	IDA		Human	PMID:18073297
Biological Process	GO:0033198	response to ATP	Kcnj11	IGI	UniProtKB:Q63563	Rat	PMID:28842488\|RGD:14995313
Biological Process	GO:0032355	response to estradiol	Kcnj11	IEP		Rat	PMID:23032400\|RGD:7296927
Biological Process	GO:0002931	response to ischemia	Kcnj11	IEP		Rat	PMID:20971764\|RGD:7296940
Biological Process	GO:0033574	response to testosterone	Kcnj11	IEP		Rat	PMID:18950632\|RGD:2311537
Biological Process	GO:0009410	response to xenobiotic stimulus	KCNJ11	IMP		Human	PMID:18073297
Biological Process	GO:0009410	response to xenobiotic stimulus	Kcnj11	IEP		Rat	PMID:15964031\|RGD:1598644
Biological Process	GO:0003323	type B pancreatic cell development	kcnj11	IMP	ZFIN:ZDB-MRPHLNO-160621-43	Zfish	PMID:26963759

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.