Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNJ2
  • Mouse genes Kcnj2
  • Rat genes Kcnj2
  • Zfish genes kcnj2a,kcnj2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnj2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	KCNJ2	IPI	UniProtKB:P63252	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Kcnj2	IPI	UniProtKB:P35561	Mouse	MGI:MGI:5294504|PMID:21703452
Molecular Function	GO:0042802	identical protein binding	Kcnj2	IPI	UniProtKB:P35561	Mouse	MGI:MGI:5572874|PMID:16834334
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNJ2	IDA		Human	PMID:11371347
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNJ2	IDA		Human	PMID:12086641
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNJ2	IDA		Human	PMID:20921230
Molecular Function	GO:0005242	inward rectifier potassium channel activity	kcnj2a	IDA		Zfish	PMID:25991088
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	KCNJ2	IDA		Human	PMID:12086641
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q14160	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:A0A0S2Z4U3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:B7U540	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q99712	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:B7U540	Human	PMID:32541000
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q14160	Human	PMID:32541000
Molecular Function	GO:0005515	protein binding	KCNJ2	IPI	UniProtKB:Q3SXY8	Human	PMID:32541000
Molecular Function	GO:0005515	protein binding	Kcnj2	IPI	UniProtKB:Q2YHQ3	Mouse	MGI:MGI:3687890|PMID:12923176
Molecular Function	GO:0005515	protein binding	Kcnj2	IPI	UniProtKB:P24588	Mouse	MGI:MGI:3688069|PMID:11287423
Molecular Function	GO:0005515	protein binding	Kcnj2	IPI	UniProtKB:B2RYN6	Mouse	MGI:MGI:5294504|PMID:21703452
Molecular Function	GO:0005515	protein binding	Kcnj2	IPI	UniProtKB:Q15700-4	Mouse	MGI:MGI:3688349|PMID:15304517
Molecular Function	GO:0005515	protein binding	Kcnj2	IPI	UniProtKB:Q62696	Rat	PMID:22509027|RGD:13432265
Molecular Function	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	KCNJ2	IMP		Human	PMID:11371347
Cellular Component	GO:0030425	dendrite	Kcnj2	IDA		Rat	PMID:12591157|RGD:1581468
Cellular Component	GO:0043197	dendritic spine	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0098978	glutamatergic synapse	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0005794	Golgi apparatus	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0014704	intercalated disc	Kcnj2	IDA		Rat	PMID:23640888|RGD:7247427
Cellular Component	GO:0016020	membrane	KCNJ2	IDA		Human	PMID:20921230
Cellular Component	GO:0043025	neuronal cell body	Kcnj2	IDA		Rat	PMID:12591157|RGD:1581468
Cellular Component	GO:0005886	plasma membrane	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0045211	postsynaptic membrane	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0005791	rough endoplasmic reticulum	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Kcnj2	IDA		Rat	PMID:18076085|RGD:7247433
Cellular Component	GO:0030315	T-tubule	Kcnj2	IDA		Rat	PMID:23640888|RGD:7247427
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNJ2	IDA		Human	PMID:12086641
Biological Process	GO:0086001	cardiac muscle cell action potential	Kcnj2	IMP		Mouse	PMID:15581370
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	KCNJ2	IMP		Human	PMID:11371347
Biological Process	GO:0071260	cellular response to mechanical stimulus	Kcnj2	IEP		Rat	PMID:17293496|RGD:7247436
Biological Process	GO:0015693	magnesium ion transport	Kcnj2	IDA		Mouse	PMID:8189383
Biological Process	GO:0086011	membrane repolarization during action potential	KCNJ2	IMP		Human	PMID:11371347
Biological Process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	KCNJ2	IMP		Human	PMID:11371347
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	Kcnj2	IMP		Rat	PMID:22426100|RGD:7247430
Biological Process	GO:1990573	potassium ion import across plasma membrane	KCNJ2	IDA		Human	PMID:11371347
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNJ2	IDA		Human	PMID:12086641
Biological Process	GO:0071805	potassium ion transmembrane transport	kcnj2a	IDA		Zfish	PMID:25991088|ZFIN:ZDB-PUB-150521-7
Biological Process	GO:0006813	potassium ion transport	KCNJ2	IDA		Human	PMID:20921230
Biological Process	GO:0051289	protein homotetramerization	KCNJ2	IDA		Human	PMID:20921230
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Kcnj2	IMP		Rat	PMID:22426100|RGD:7247430
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNJ2	IMP		Human	PMID:15761194
Biological Process	GO:0060306	regulation of membrane repolarization	KCNJ2	IDA		Human	PMID:11371347
Biological Process	GO:0014861	regulation of skeletal muscle contraction via regulation of action potential	KCNJ2	IMP		Human	PMID:11371347
Biological Process	GO:0055119	relaxation of cardiac muscle	KCNJ2	IMP		Human	PMID:11371347
Biological Process	GO:0090076	relaxation of skeletal muscle	KCNJ2	IMP		Human	PMID:11371347

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern