Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNJ8
  • Mouse genes Kcnj8
  • Rat genes Kcnj8
  • Zfish genes kcnj8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnj8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Kcnj8	IDA		Rat	PMID:11956191|RGD:14995323
Molecular Function	GO:0005524	ATP binding	Kcnj8	IDA		Rat	PMID:15775962|RGD:1581688
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	KCNJ8	IDA		Human	PMID:20558321
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	Kcnj8	IDA		Rat	PMID:17097686|RGD:1625274
Molecular Function	GO:0015272	ATP-activated inward rectifier potassium channel activity	Kcnj8	IDA		Rat	PMID:7890693|RGD:1566541
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	Kcnj8	IGI	UniProtKB:A0A1S4NYG1,UniProtKB:A0A1U7R319	Rat	PMID:28842488|RGD:14995313
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	Kcnj8	IGI	UniProtKB:Q63563	Rat	PMID:28842488|RGD:14995313
Molecular Function	GO:0005515	protein binding	KCNJ8	IPI	UniProtKB:P50402	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ8	IPI	UniProtKB:Q969K7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNJ8	IPI	UniProtKB:Q9NV12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kcnj8	IPI	RGD:2280	Rat	PMID:15499025|RGD:1581678
Molecular Function	GO:0005515	protein binding	Kcnj8	IPI	UniProtKB:P08050	Rat	PMID:22960107|RGD:10047305
Molecular Function	GO:0005515	protein binding	Kcnj8	IPI	UniProtKB:P23242	Rat	PMID:22960107|RGD:10047305
Molecular Function	GO:0017098	sulfonylurea receptor binding	Kcnj8	IPI	RGD:11362	Rat	PMID:20123112|RGD:7243110
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNJ8	IDA		Human	PMID:18945825
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNJ8	IMP		Human	PMID:18945825
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCNJ8	IMP		Human	PMID:20558321
Cellular Component	GO:0098978	glutamatergic synapse	Kcnj8	IDA		Rat	PMID:17883401|RGD:155230746
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Kcnj8	IDA		Rat	PMID:15983113|RGD:1625265
Cellular Component	GO:0008282	inward rectifying potassium channel	Kcnj8	IDA		Rat	PMID:17097686|RGD:1625274
Cellular Component	GO:0016020	membrane	Kcnj8	IDA		Rat	PMID:15499025|RGD:1581678
Cellular Component	GO:0005739	mitochondrion	Kcnj8	IDA		Rat	PMID:22466787|RGD:12791999
Cellular Component	GO:0005739	mitochondrion	Kcnj8	IDA		Rat	PMID:15983113|RGD:1625265
Cellular Component	GO:0005739	mitochondrion	Kcnj8	IDA		Rat	PMID:16050978|RGD:1598643
Cellular Component	GO:0030016	myofibril	Kcnj8	IDA		Mouse	PMID:16085792
Cellular Component	GO:0048787	presynaptic active zone membrane	Kcnj8	IDA		Rat	PMID:17883401|RGD:155230746
Cellular Component	GO:0042383	sarcolemma	Kcnj8	IDA		Rat	PMID:15647111|RGD:1598637
Biological Process	GO:0051607	defense response to virus	Kcnj8	IMP	MGI:MGI:3720053	Mouse	PMID:18026101
Biological Process	GO:0051607	defense response to virus	Kcnj8	IMP	MGI:MGI:3626350	Mouse	PMID:18026101
Biological Process	GO:0051607	defense response to virus	Kcnj8	IMP	MGI:MGI:3626349	Mouse	PMID:18026101
Biological Process	GO:0051607	defense response to virus	Kcnj8	IMP	MGI:MGI:3626348	Mouse	PMID:18026101
Biological Process	GO:0007507	heart development	Kcnj8	IMP	MGI:MGI:3720053	Mouse	PMID:18026101
Biological Process	GO:0098662	inorganic cation transmembrane transport	Kcnj8	IGI	UniProtKB:A0A1S4NYG1,UniProtKB:A0A1U7R319	Rat	PMID:28842488|RGD:14995313
Biological Process	GO:0098662	inorganic cation transmembrane transport	Kcnj8	IGI	UniProtKB:Q63563	Rat	PMID:28842488|RGD:14995313
Biological Process	GO:0001822	kidney development	Kcnj8	IEP		Rat	PMID:12466933|RGD:1566579
Biological Process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	KCNJ8	IMP		Human	PMID:20558321
Biological Process	GO:1990573	potassium ion import across plasma membrane	KCNJ8	IDA		Human	PMID:20558321
Biological Process	GO:1990573	potassium ion import across plasma membrane	Kcnj8	IDA		Rat	PMID:7890693|RGD:1566541
Biological Process	GO:0006813	potassium ion transport	Kcnj8	IMP		Rat	PMID:16048905|RGD:1625261
Biological Process	GO:0006813	potassium ion transport	Kcnj8	IDA		Rat	PMID:17097686|RGD:1625274
Biological Process	GO:0043330	response to exogenous dsRNA	Kcnj8	IMP	MGI:MGI:3720053	Mouse	PMID:18026101
Biological Process	GO:0032496	response to lipopolysaccharide	Kcnj8	IMP	MGI:MGI:3720053	Mouse	PMID:18026101

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern