Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNK1
  • Mouse genes Kcnk1
  • Rat genes Kcnk1
  • Zfish genes kcnk1a,kcnk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	KCNK1	IPI	UniProtKB:O00180	Human	PMID:20498050
Molecular Function	GO:0042802	identical protein binding	KCNK1	IPI	UniProtKB:O00180	Human	PMID:22282804
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcnk1	IDA		Mouse	MGI:MGI:85503|PMID:9013852
Molecular Function	GO:0015271	outward rectifier potassium channel activity	kcnk1a	IDA		Zfish	PMID:21963410
Molecular Function	GO:0005267	potassium channel activity	KCNK1	IDA		Human	PMID:22282804
Molecular Function	GO:0005267	potassium channel activity	Kcnk1	IDA		Mouse	PMID:15540117
Molecular Function	GO:0005267	potassium channel activity	kcnk1a	IDA		Zfish	PMID:27103460
Molecular Function	GO:0005267	potassium channel activity	kcnk1b	IDA		Zfish	PMID:27103460
Molecular Function	GO:0022841	potassium ion leak channel activity	KCNK1	IDA		Human	PMID:21653227
Molecular Function	GO:0022841	potassium ion leak channel activity	Kcnk1	IDA		Rat	PMID:19571146|RGD:9831119
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:P63165	Human	PMID:20498050
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:O14735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:P27105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:Q8IV31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNK1	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kcnk1	IPI	UniProtKB:Q8IVG0	Mouse	PMID:15540117
Molecular Function	GO:0005272	sodium channel activity	KCNK1	IDA		Human	PMID:21653227
Cellular Component	GO:0016324	apical plasma membrane	Kcnk1	IDA		Rat	PMID:12855359|RGD:2316518
Cellular Component	GO:0031526	brush border membrane	Kcnk1	IDA		Rat	PMID:9843722|RGD:2316520
Cellular Component	GO:0005737	cytoplasm	Kcnk1	IDA		Rat	PMID:9843722|RGD:2316520
Cellular Component	GO:0005768	endosome	Kcnk1	IDA		Mouse	PMID:15540117
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KCNK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:1902937	inward rectifier potassium channel complex	Kcnk1	IDA		Mouse	MGI:MGI:85503|PMID:9013852
Cellular Component	GO:0016020	membrane	KCNK1	IDA		Human	PMID:22282804
Cellular Component	GO:0005886	plasma membrane	KCNK1	IDA		Human	PMID:21653227
Cellular Component	GO:0005886	plasma membrane	Kcnk1	IMP		Mouse	MGI:MGI:85503|PMID:9013852
Cellular Component	GO:0005886	plasma membrane	Kcnk1	IMP		Rat	PMID:19571146|RGD:9831119
Cellular Component	GO:0034705	potassium channel complex	KCNK1	IDA		Human	PMID:22282804
Biological Process	GO:0003015	heart process	kcnk1a	IGI	ZFIN:ZDB-MRPHLNO-161107-1,ZFIN:ZDB-MRPHLNO-161107-2	Zfish	PMID:27103460
Biological Process	GO:0003015	heart process	kcnk1a	IMP	ZFIN:ZDB-MRPHLNO-161107-3	Zfish	PMID:27103460
Biological Process	GO:0003015	heart process	kcnk1a	IMP	ZFIN:ZDB-MRPHLNO-161107-1	Zfish	PMID:27103460
Biological Process	GO:0003015	heart process	kcnk1b	IMP	ZFIN:ZDB-MRPHLNO-161107-2	Zfish	PMID:27103460
Biological Process	GO:0003015	heart process	kcnk1b	IGI	ZFIN:ZDB-MRPHLNO-161107-1,ZFIN:ZDB-MRPHLNO-161107-2	Zfish	PMID:27103460
Biological Process	GO:0003015	heart process	kcnk1b	IMP	ZFIN:ZDB-MRPHLNO-161107-4	Zfish	PMID:27103460
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNK1	IDA		Human	PMID:21653227
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNK1	IDA		Human	PMID:22282804
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnk1	IDA		Mouse	MGI:MGI:85503|PMID:9013852
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnk1	IDA		Rat	PMID:19571146|RGD:9831119
Biological Process	GO:0071805	potassium ion transmembrane transport	kcnk1a	IDA		Zfish	PMID:21963410|ZFIN:ZDB-PUB-111019-3
Biological Process	GO:0060075	regulation of resting membrane potential	KCNK1	IMP		Human	PMID:21653227
Biological Process	GO:0035094	response to nicotine	Kcnk1	IEP		Rat	PMID:11478936|RGD:2316519
Biological Process	GO:0035725	sodium ion transmembrane transport	KCNK1	IDA		Human	PMID:21653227

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern