Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcnk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNK2
- Mouse genes Kcnk2
- Rat genes Kcnk2
- Zfish genes kcnk2a,kcnk2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	kcnk2b	IDA		Zfish	PMID:30333618
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	kcnk2a	IDA		Zfish	PMID:30333618
Molecular Function	GO:0015271	outward rectifier potassium channel activity	Kcnk2	IDA		Rat	PMID:11319556\|RGD:633144
Molecular Function	GO:0015271	outward rectifier potassium channel activity	Kcnk2	IDA		Rat	PMID:24196565\|RGD:8661627
Molecular Function	GO:0019870	potassium channel inhibitor activity	Kcnk2	IDA		Rat	PMID:24196565\|RGD:8661627
Molecular Function	GO:0022841	potassium ion leak channel activity	Kcnk2	IDA		Rat	PMID:11319556\|RGD:633144
Molecular Function	GO:0022841	potassium ion leak channel activity	Kcnk2	IDA		Rat	PMID:19571146\|RGD:9831119
Molecular Function	GO:0022841	potassium ion leak channel activity	kcnk2a	IDA		Zfish	PMID:33345771
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	UniProtKB:Q8NE79	Mouse	MGI:MGI:5751625\|PMID:26642364
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	UniProtKB:D3YVF0	Mouse	MGI:MGI:3703490\|PMID:17110924
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	UniProtKB:Q6PHU5	Mouse	MGI:MGI:4452544\|PMID:20405001
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	PR:Q9ES83	Mouse	PMID:22354168
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	RGD:3410	Rat	PMID:16750514\|RGD:9831180
Molecular Function	GO:0005515	protein binding	Kcnk2	IPI	UniProtKB:P50150	Rat	PMID:23021213\|RGD:8655530
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcnk2	IDA		Mouse	PMID:11560940
Cellular Component	GO:0016324	apical plasma membrane	Kcnk2	IDA		Rat	PMID:15261098\|RGD:9831118
Cellular Component	GO:0097449	astrocyte projection	Kcnk2	IDA		Rat	PMID:25062759\|RGD:9831122
Cellular Component	GO:0030424	axon	Kcnk2	IDA		Rat	PMID:10790857\|RGD:9831168
Cellular Component	GO:0043679	axon terminus	Kcnk2	IDA		Rat	PMID:18838117\|RGD:9831146
Cellular Component	GO:0044305	calyx of Held	Kcnk2	IDA		Rat	PMID:15261098\|RGD:9831118
Cellular Component	GO:0009986	cell surface	Kcnk2	IDA		Rat	PMID:22910181\|RGD:9831115
Cellular Component	GO:0005783	endoplasmic reticulum	Kcnk2	IDA		Rat	PMID:24196565\|RGD:8661627
Cellular Component	GO:0043005	neuron projection	Kcnk2	IDA		Rat	PMID:11301200\|RGD:9831123
Cellular Component	GO:0043025	neuronal cell body	Kcnk2	IDA		Rat	PMID:19571146\|RGD:9831119
Cellular Component	GO:0005634	nucleus	Kcnk2	IDA		Rat	PMID:15094499\|RGD:2316534
Cellular Component	GO:0005886	plasma membrane	Kcnk2	IDA		Mouse	PMID:22354168
Cellular Component	GO:0005886	plasma membrane	Kcnk2	IDA		Rat	PMID:11509450\|RGD:9831117
Cellular Component	GO:0005886	plasma membrane	Kcnk2	IMP		Rat	PMID:19571146\|RGD:9831119
Cellular Component	GO:0005886	plasma membrane	Kcnk2	IDA		Rat	PMID:24196565\|RGD:8661627
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcnk2	IDA		Mouse	PMID:11560940
Biological Process	GO:0003231	cardiac ventricle development	Kcnk2	IEP		Rat	PMID:24705172\|RGD:9831164
Biological Process	GO:0071456	cellular response to hypoxia	Kcnk2	IEP		Rat	PMID:24705172\|RGD:9831164
Biological Process	GO:0090102	cochlea development	Kcnk2	IEP		Rat	PMID:15094499\|RGD:2316534
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Kcnk2	IDA		Mouse	PMID:11560940
Biological Process	GO:0007613	memory	Kcnk2	IEP		Rat	PMID:14730890\|RGD:9831144
Biological Process	GO:0034220	monoatomic ion transmembrane transport	kcnk2a	IDA		Zfish	PMID:30333618\|ZFIN:ZDB-PUB-181020-8
Biological Process	GO:0034220	monoatomic ion transmembrane transport	kcnk2b	IDA		Zfish	PMID:30333618\|ZFIN:ZDB-PUB-181020-8
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Kcnk2	IMP		Rat	PMID:24705172\|RGD:9831164
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	Kcnk2	IMP		Rat	PMID:23271285\|RGD:9831181
Biological Process	GO:1900039	positive regulation of cellular response to hypoxia	Kcnk2	IMP		Rat	PMID:24705172\|RGD:9831164
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnk2	IDA		Rat	PMID:11319556\|RGD:633144
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnk2	IDA		Rat	PMID:19571146\|RGD:9831119
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcnk2	IDA		Rat	PMID:22910181\|RGD:9831115
Biological Process	GO:0006813	potassium ion transport	Kcnk2	IDA		Mouse	PMID:11560940
Biological Process	GO:0042391	regulation of membrane potential	Kcnk2	IGI	MGI:MGI:1930150	Mouse	PMID:22354168
Biological Process	GO:0042391	regulation of membrane potential	Kcnk2	IGI	MGI:MGI:1930153	Mouse	PMID:22354168
Biological Process	GO:0042391	regulation of membrane potential	Kcnk2	IGI	MGI:MGI:1346013	Mouse	PMID:22354168
Biological Process	GO:0048678	response to axon injury	Kcnk2	IEP		Rat	PMID:10790857\|RGD:9831168
Biological Process	GO:0009612	response to mechanical stimulus	Kcnk2	IEP		Rat	PMID:17828492\|RGD:9831147

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.