Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNK3
  • Mouse genes Kcnk3
  • Rat genes Kcnk3
  • Zfish genes kcnk3a,kcnk3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005216	monoatomic ion channel activity	KCNK3	IMP		Human	PMID:12198146
Molecular Function	GO:0005252	open rectifier potassium channel activity	Kcnk3	IDA		Rat	PMID:9437008|RGD:61647
Molecular Function	GO:0022841	potassium ion leak channel activity	KCNK3	IDA		Human	PMID:9312005
Molecular Function	GO:0005515	protein binding	Kcnk3	IPI	RGD:61998	Rat	PMID:12437930|RGD:2306038
Molecular Function	GO:0005515	protein binding	Kcnk3	IPI	RGD:628655	Rat	PMID:16420525|RGD:2316524
Molecular Function	GO:0044548	S100 protein binding	KCNK3	IPI	UniProtKB:P60903	Human	PMID:12198146
Cellular Component	GO:0005886	plasma membrane	KCNK3	IMP		Human	PMID:12198146
Cellular Component	GO:0005886	plasma membrane	Kcnk3	IDA		Rat	PMID:16420525|RGD:2316524
Biological Process	GO:0007420	brain development	Kcnk3	IEP		Rat	PMID:15167558|RGD:2316532
Biological Process	GO:0071456	cellular response to hypoxia	Kcnk3	IMP		Rat	PMID:12215606|RGD:2316539
Biological Process	GO:0071294	cellular response to zinc ion	Kcnk3	IEP		Rat	PMID:9437008|RGD:61647
Biological Process	GO:0090102	cochlea development	Kcnk3	IEP		Rat	PMID:15094499|RGD:2316534
Biological Process	GO:0060047	heart contraction	kcnk3a	IGI	ZFIN:ZDB-MRPHLNO-140321-3,ZFIN:ZDB-MRPHLNO-140328-13	Zfish	PMID:24374141
Biological Process	GO:0060047	heart contraction	kcnk3b	IGI	ZFIN:ZDB-MRPHLNO-140321-3,ZFIN:ZDB-MRPHLNO-140328-13	Zfish	PMID:24374141
Biological Process	GO:0034220	monoatomic ion transmembrane transport	KCNK3	IMP		Human	PMID:12198146
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Kcnk3	IMP		Rat	PMID:16436472|RGD:2316523
Biological Process	GO:1903818	positive regulation of voltage-gated potassium channel activity	Kcnk3	IMP		Rat	PMID:31347976|RGD:151347452
Biological Process	GO:0006813	potassium ion transport	Kcnk3	IDA		Rat	PMID:15282272|RGD:2316529
Biological Process	GO:0060075	regulation of resting membrane potential	Kcnk3	IMP		Rat	PMID:31347976|RGD:151347452
Biological Process	GO:0009410	response to xenobiotic stimulus	Kcnk3	IMP		Rat	PMID:14637154|RGD:2316536
Biological Process	GO:0009410	response to xenobiotic stimulus	Kcnk3	IEP		Rat	PMID:9437008|RGD:61647

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern