Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KCNN4
  • Mouse genes Kcnn4
  • Rat genes Kcnn4
  • Zfish genes kcnn4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcnn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015269	calcium-activated potassium channel activity	KCNN4	IDA		Human	PMID:18796614
Molecular Function	GO:0015269	calcium-activated potassium channel activity	KCNN4	IDA		Human	PMID:26148990
Molecular Function	GO:0015269	calcium-activated potassium channel activity	Kcnn4	IDA		Mouse	PMID:12388098
Molecular Function	GO:0015269	calcium-activated potassium channel activity	Kcnn4	IDA		Mouse	PMID:11724775
Molecular Function	GO:0022894	Intermediate conductance calcium-activated potassium channel activity	Kcnn4	IDA		Rat	PMID:10532960|RGD:633066
Molecular Function	GO:0022894	Intermediate conductance calcium-activated potassium channel activity	Kcnn4	IDA		Rat	PMID:12606302|RGD:7175510
Molecular Function	GO:0022894	Intermediate conductance calcium-activated potassium channel activity	Kcnn4	IDA		Rat	PMID:20616305|RGD:7175508
Molecular Function	GO:0022894	Intermediate conductance calcium-activated potassium channel activity	Kcnn4	IDA		Rat	PMID:21868633|RGD:7175507
Molecular Function	GO:0005267	potassium channel activity	Kcnn4	IGI	MGI:MGI:99923	Mouse	PMID:16873365
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q59HJ6	Human	PMID:12198491
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q9NRX4	Human	PMID:18796614
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:P13569	Human	PMID:27092946
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:P61266	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q01453	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q14802-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q8TBE1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KCNN4	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0019903	protein phosphatase binding	KCNN4	IPI	UniProtKB:Q9NRX4	Human	PMID:18796614
Cellular Component	GO:0016324	apical plasma membrane	Kcnn4	IDA		Rat	PMID:12606302|RGD:7175510
Cellular Component	GO:0016324	apical plasma membrane	Kcnn4	IDA		Rat	PMID:21868633|RGD:7175507
Cellular Component	GO:0016323	basolateral plasma membrane	Kcnn4	IDA		Rat	PMID:12606302|RGD:7175510
Cellular Component	GO:0005829	cytosol	KCNN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	Kcnn4	IDA		Rat	PMID:17264085|RGD:7175509
Cellular Component	GO:0043025	neuronal cell body	Kcnn4	IDA		Rat	PMID:15680700|RGD:7205443
Cellular Component	GO:0005886	plasma membrane	KCNN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	KCNN4	IDA		Human	PMID:26148990
Cellular Component	GO:0031982	vesicle	KCNN4	IDA		Human	PMID:25468996
Biological Process	GO:0006816	calcium ion transport	KCNN4	IDA		Human	PMID:18796614
Biological Process	GO:0006884	cell volume homeostasis	Kcnn4	IMP	MGI:MGI:3521668	Mouse	PMID:18097031
Biological Process	GO:0051649	establishment of localization in cell	Kcnn4	IMP	MGI:MGI:3521668	Mouse	PMID:18097031
Biological Process	GO:0006820	monoatomic anion transport	Kcnn4	IDA		Rat	PMID:20616305|RGD:7175508
Biological Process	GO:0045332	phospholipid translocation	Kcnn4	IMP	MGI:MGI:3521668	Mouse	PMID:18097031
Biological Process	GO:0050714	positive regulation of protein secretion	Kcnn4	IDA		Mouse	PMID:11724775
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	KCNN4	IDA		Human	PMID:18796614
Biological Process	GO:0097623	potassium ion export across plasma membrane	Kcnn4	IDA		Rat	PMID:12606302|RGD:7175510
Biological Process	GO:0097623	potassium ion export across plasma membrane	Kcnn4	IDA		Rat	PMID:20616305|RGD:7175508
Biological Process	GO:0006813	potassium ion transport	Kcnn4	IDA		Rat	PMID:10532960|RGD:633066
Biological Process	GO:0046541	saliva secretion	Kcnn4	IGI	MGI:MGI:99923	Mouse	PMID:16873365
Biological Process	GO:0030322	stabilization of membrane potential	KCNN4	IDA		Human	PMID:18796614

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern