Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM2A
  • Mouse genes Kdm2a
  • Rat genes Kdm2a
  • Zfish genes kdm2aa,kdm2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM2A	IMP		Human	PMID:20417597
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM2A	IMP		Human	PMID:21187428
Molecular Function	GO:0051864	histone H3K36 demethylase activity	KDM2A	IMP		Human	PMID:28262558
Molecular Function	GO:0005515	protein binding	KDM2A	IPI	UniProtKB:P63208	Human	PMID:15070733
Molecular Function	GO:0005515	protein binding	KDM2A	IPI	UniProtKB:Q04206	Human	PMID:20080798
Molecular Function	GO:0005515	protein binding	KDM2A	IPI	UniProtKB:P63208	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KDM2A	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0045322	unmethylated CpG binding	KDM2A	IDA		Human	PMID:29276034
Molecular Function	GO:0045322	unmethylated CpG binding	Kdm2a	IDA		Mouse	PMID:20417597
Molecular Function	GO:0008270	zinc ion binding	KDM2A	IDA		Human	PMID:29276034
Cellular Component	GO:0000785	chromatin	Kdm2a	IDA		Mouse	MGI:MGI:6694658|PMID:32584788
Cellular Component	GO:0000785	chromatin	Kdm2a	IDA		Mouse	PMID:20417597
Cellular Component	GO:0005654	nucleoplasm	KDM2A	IDA		Human	GO_REF:0000052
Biological Process	GO:0032922	circadian regulation of gene expression	KDM2A	IMP		Human	PMID:26037310
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	KDM2A	IMP		Human	PMID:21187428
Biological Process	GO:0001947	heart looping	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0070544	histone H3-K36 demethylation	Kdm2a	IMP		Mouse	MGI:MGI:6694658|PMID:32584788
Biological Process	GO:0001701	in utero embryonic development	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0035264	multicellular organism growth	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0043066	negative regulation of apoptotic process	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0010629	negative regulation of gene expression	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	KDM2A	IMP		Human	PMID:26037310
Biological Process	GO:0001843	neural tube closure	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0060563	neuroepithelial cell differentiation	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0030182	neuron differentiation	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0010628	positive regulation of gene expression	Kdm2a	IMP		Mouse	PMID:25463925
Biological Process	GO:0042752	regulation of circadian rhythm	KDM2A	IMP		Human	PMID:26037310
Biological Process	GO:0007530	sex determination	kdm2aa	IMP	ZFIN:ZDB-GENO-171121-3	Zfish	PMID:28806732
Biological Process	GO:0007530	sex determination	kdm2aa	IMP	ZFIN:ZDB-GENO-171121-1	Zfish	PMID:28806732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern