Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM5A
  • Mouse genes Kdm5a
  • Rat genes Kdm5a
  • Zfish genes kdm5a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Kdm5a	IDA		Mouse	MGI:MGI:4431292|PMID:20064375
Molecular Function	GO:0031490	chromatin DNA binding	Kdm5a	IDA		Mouse	PMID:18483221
Molecular Function	GO:0003677	DNA binding	KDM5A	IDA		Human	PMID:15640446
Molecular Function	GO:0004857	enzyme inhibitor activity	Kdm5a	IDA		Mouse	MGI:MGI:5288521|PMID:21960634
Molecular Function	GO:0042393	histone binding	KDM5A	IDA		Human	PMID:19430464
Molecular Function	GO:0032453	histone H3K4 demethylase activity	Kdm5a	IMP		Mouse	PMID:18483221
Molecular Function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5A	IDA		Human	PMID:18270511
Molecular Function	GO:0035064	methylated histone binding	KDM5A	IDA		Human	PMID:19430464
Molecular Function	GO:0005515	protein binding	KDM5A	IPI	UniProtKB:O00327	Human	PMID:21960634
Molecular Function	GO:0005515	protein binding	KDM5A	IPI	UniProtKB:O15516	Human	PMID:21960634
Molecular Function	GO:0005515	protein binding	KDM5A	IPI	UniProtKB:P06400	Human	PMID:22615382
Molecular Function	GO:0005515	protein binding	Kdm5a	IPI	UniProtKB:O08785|UniProtKB:O09106|UniProtKB:Q9WTL8	Mouse	MGI:MGI:5288521|PMID:21960634
Molecular Function	GO:0005515	protein binding	Kdm5a	IPI	UniProtKB:Q80U70	Mouse	MGI:MGI:4431292|PMID:20064375
Molecular Function	GO:0000976	transcription cis-regulatory region binding	KDM5A	IMP		Human	PMID:18270511
Molecular Function	GO:0003713	transcription coactivator activity	Kdm5a	IDA		Mouse	MGI:MGI:5288521|PMID:21960634
Molecular Function	GO:0008270	zinc ion binding	KDM5A	IDA		Human	PMID:19430464
Molecular Function	GO:0008270	zinc ion binding	KDM5A	IDA		Human	PMID:27499454
Cellular Component	GO:0005634	nucleus	KDM5A	IDA		Human	PMID:18270511
Cellular Component	GO:0005634	nucleus	Kdm5a	IDA		Mouse	PMID:18483221
Cellular Component	GO:0032993	protein-DNA complex	Kdm5a	IDA		Mouse	PMID:18483221
Biological Process	GO:0032922	circadian regulation of gene expression	Kdm5a	IMP		Mouse	MGI:MGI:5288521|PMID:21960634
Biological Process	GO:0140718	facultative heterochromatin formation	Kdm5a	IDA		Mouse	MGI:MGI:4431292|PMID:20064375
Biological Process	GO:0016570	histone modification	Kdm5a	IMP		Mouse	MGI:MGI:3789777|PMID:18483221
Biological Process	GO:0016570	histone modification	Kdm5a	IEP		Rat	PMID:24679876|RGD:9588526
Biological Process	GO:0008584	male gonad development	Kdm5a	IEP		Rat	PMID:24679876|RGD:9588526
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Kdm5a	IMP		Mouse	PMID:18483221
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KDM5A	IDA		Human	PMID:11358960
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	KDM5A	IMP		Human	PMID:18270511
Biological Process	GO:0007283	spermatogenesis	Kdm5a	IEP		Rat	PMID:24679876|RGD:9588526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern