Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDM5B
  • Mouse genes Kdm5b
  • Rat genes Kdm5b
  • Zfish genes kdm5ba,kdm5bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm5b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	KDM5B	IDA		Human	PMID:15640446
Molecular Function	GO:0042393	histone binding	KDM5B	IDA		Human	PMID:24952722
Molecular Function	GO:0032453	histone H3K4 demethylase activity	KDM5B	IDA		Human	PMID:18048344
Molecular Function	GO:0032453	histone H3K4 demethylase activity	KDM5B	IMP		Human	PMID:24952722
Molecular Function	GO:0032453	histone H3K4 demethylase activity	KDM5B	IMP		Human	PMID:27214403
Molecular Function	GO:0032453	histone H3K4 demethylase activity	KDM5B	IMP		Human	PMID:28262558
Molecular Function	GO:0032453	histone H3K4 demethylase activity	Kdm5b	IDA		Mouse	PMID:17320160
Molecular Function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B	IDA		Human	PMID:20228790
Molecular Function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B	IMP		Human	PMID:20403335
Molecular Function	GO:0003676	nucleic acid binding	KDM5B	EXP		Human	PMID:20403335
Molecular Function	GO:0005515	protein binding	KDM5B	IPI	UniProtKB:P55316	Human	PMID:12657635
Molecular Function	GO:0005515	protein binding	KDM5B	IPI	UniProtKB:P55771	Human	PMID:12657635
Molecular Function	GO:0005515	protein binding	KDM5B	IPI	UniProtKB:P49711	Human	PMID:24937458
Molecular Function	GO:0005515	protein binding	Kdm5b	IPI	UniProtKB:P60762	Mouse	MGI:MGI:4949547|PMID:21448134
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KDM5B	IMP		Human	PMID:20403335
Molecular Function	GO:0003714	transcription corepressor activity	KDM5B	IDA		Human	PMID:12657635
Molecular Function	GO:0008270	zinc ion binding	KDM5B	IDA		Human	PMID:24952722
Molecular Function	GO:0008270	zinc ion binding	KDM5B	IDA		Human	PMID:27214403
Molecular Function	GO:0008270	zinc ion binding	KDM5B	IMP		Human	PMID:28262558
Cellular Component	GO:0005829	cytosol	KDM5B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KDM5B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KDM5B	IDA		Human	PMID:20403335
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Kdm5b	IEP		Rat	PMID:24142921|RGD:9587771
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Kdm5b	IEP		Mouse	PMID:20439489
Biological Process	GO:0070306	lens fiber cell differentiation	Kdm5b	IEP		Rat	PMID:24142921|RGD:9587771
Biological Process	GO:0060763	mammary duct terminal end bud growth	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Kdm5b	IDA		Mouse	MGI:MGI:5288521|PMID:21960634
Biological Process	GO:0010628	positive regulation of gene expression	Kdm5b	IGI	MGI:MGI:95663	Mouse	PMID:24802759
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:0009791	post-embryonic development	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:2000864	regulation of estradiol secretion	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:0060992	response to fungicide	Kdm5b	IEP		Rat	PMID:22496781|RGD:9588300
Biological Process	GO:0007338	single fertilization	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759
Biological Process	GO:0061038	uterus morphogenesis	Kdm5b	IMP	MGI:MGI:4329395	Mouse	PMID:24802759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern