Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kdm6b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KDM6B
- Mouse genes Kdm6b
- Rat genes Kdm6b
- Zfish genes kdm6ba,kdm6bb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdm6b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Kdm6b	IPI	UniProtKB:Q02248	Mouse	MGI:MGI:5574281\|PMID:23856522
Molecular Function	GO:0003682	chromatin binding	Kdm6b	IDA		Rat	PMID:23932971\|RGD:9587811
Molecular Function	GO:0061628	H3K27me3 modified histone binding	kdm6bb	IDA		Zfish	PMID:29378332
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	KDM6B	IMP		Human	PMID:28262558
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	Kdm6b	IDA		Mouse	MGI:MGI:5574281\|PMID:23856522
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	Kdm6b	IMP		Mouse	PMID:18716661
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	Kdm6b	IMP		Mouse	PMID:17928865
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	kdm6bb	IDA		Zfish	PMID:29378332
Molecular Function	GO:0005515	protein binding	KDM6B	IPI	UniProtKB:P03372	Human	PMID:21841772
Molecular Function	GO:0005515	protein binding	Kdm6b	IPI	UniProtKB:P97496\|UniProtKB:Q3TKT4\|UniProtKB:Q6PDG5\|UniProtKB:Q9JKD8	Mouse	MGI:MGI:4866963\|PMID:21095589
Molecular Function	GO:0043565	sequence-specific DNA binding	Kdm6b	IDA		Mouse	PMID:17928865
Cellular Component	GO:0005634	nucleus	Kdm6b	IDA		Mouse	MGI:MGI:5574281\|PMID:23856522
Cellular Component	GO:0005634	nucleus	Kdm6b	IDA		Rat	PMID:23932971\|RGD:9587811
Biological Process	GO:0055007	cardiac muscle cell differentiation	Kdm6b	IMP		Mouse	MGI:MGI:5574281\|PMID:23856522
Biological Process	GO:0045165	cell fate commitment	Kdm6b	IMP		Mouse	PMID:18716661
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Kdm6b	IDA		Mouse	PMID:20808772
Biological Process	GO:0006338	chromatin remodeling	Kdm6b	IMP		Mouse	MGI:MGI:4866963\|PMID:21095589
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	kdm6bb	IMP	ZFIN:ZDB-MRPHLNO-180706-1	Zfish	PMID:29378332
Biological Process	GO:0045446	endothelial cell differentiation	Kdm6b	IMP		Mouse	MGI:MGI:5574281\|PMID:23856522
Biological Process	GO:0031101	fin regeneration	kdm6bb	IMP	ZFIN:ZDB-MRPHLNO-100218-8	Zfish	PMID:19897725
Biological Process	GO:0031101	fin regeneration	kdm6bb	IMP	ZFIN:ZDB-MRPHLNO-100218-10	Zfish	PMID:19897725
Biological Process	GO:0007507	heart development	kdm6bb	IGI	ZFIN:ZDB-GENO-180716-6	Zfish	PMID:28372944
Biological Process	GO:0007507	heart development	kdm6bb	IGI	ZFIN:ZDB-GENO-180712-1	Zfish	PMID:28372944
Biological Process	GO:0007507	heart development	kdm6ba	IGI	ZFIN:ZDB-GENO-180716-6	Zfish	PMID:28372944
Biological Process	GO:0007507	heart development	kdm6ba	IGI	ZFIN:ZDB-GENO-180712-1	Zfish	PMID:28372944
Biological Process	GO:0061384	heart trabecula morphogenesis	kdm6bb	IGI	ZFIN:ZDB-GENO-180712-1	Zfish	PMID:28372944
Biological Process	GO:0061384	heart trabecula morphogenesis	kdm6ba	IGI	ZFIN:ZDB-GENO-180712-1	Zfish	PMID:28372944
Biological Process	GO:0021766	hippocampus development	Kdm6b	IDA		Rat	PMID:23932971\|RGD:9587811
Biological Process	GO:0071557	histone H3-K27 demethylation	Kdm6b	IDA		Mouse	MGI:MGI:5574281\|PMID:23856522
Biological Process	GO:0016570	histone modification	Kdm6b	IMP		Mouse	MGI:MGI:3809360\|PMID:18716661
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Kdm6b	IEP		Rat	PMID:23418092\|RGD:9587822
Biological Process	GO:0048333	mesodermal cell differentiation	Kdm6b	IMP		Mouse	MGI:MGI:5574281\|PMID:23856522
Biological Process	GO:0030099	myeloid cell differentiation	kdm6bb	IGI	ZFIN:ZDB-GENE-980526-164,ZFIN:ZDB-MRPHLNO-180706-1	Zfish	PMID:29378332
Biological Process	GO:0030099	myeloid cell differentiation	kdm6bb	IMP	ZFIN:ZDB-MRPHLNO-180706-2	Zfish	PMID:29378332
Biological Process	GO:0002262	myeloid cell homeostasis	kdm6bb	IMP	ZFIN:ZDB-MRPHLNO-180706-2	Zfish	PMID:29378332
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Kdm6b	IMP		Mouse	MGI:MGI:5702501\|PMID:26625958
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kdm6b	IMP		Mouse	MGI:MGI:5574281\|PMID:23856522
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kdm6b	IMP		Mouse	PMID:17928865
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kdm6b	IDA		Mouse	PMID:17928865
Biological Process	GO:0060319	primitive erythrocyte differentiation	kdm6bb	IMP		Zfish	PMID:24240475
Biological Process	GO:0010468	regulation of gene expression	Kdm6b	IMP		Mouse	PMID:18716661
Biological Process	GO:0014823	response to activity	Kdm6b	IEP		Rat	PMID:23418092\|RGD:9587822
Biological Process	GO:0060992	response to fungicide	Kdm6b	IEP		Rat	PMID:22496781\|RGD:9588300

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.