Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KDSR
  • Mouse genes Kdsr
  • Rat genes Kdsr
  • Zfish genes kdsr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kdsr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047560	3-dehydrosphinganine reductase activity	KDSR	IDA		Human	PMID:15364918
Molecular Function	GO:0047560	3-dehydrosphinganine reductase activity	KDSR	IMP		Human	PMID:28575652
Molecular Function	GO:0005515	protein binding	KDSR	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KDSR	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KDSR	IPI	UniProtKB:P02766	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KDSR	IPI	UniProtKB:P04792	Human	PMID:32814053
Cellular Component	GO:0005783	endoplasmic reticulum	KDSR	IDA		Human	PMID:15364918
Cellular Component	GO:0016020	membrane	KDSR	HDA		Human	PMID:19946888
Biological Process	GO:0006666	3-keto-sphinganine metabolic process	KDSR	IDA		Human	PMID:15364918
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	kdsr	IMP	ZFIN:ZDB-GENO-191121-7	Zfish	PMID:30718751
Biological Process	GO:0030220	platelet formation	kdsr	IMP	ZFIN:ZDB-MRPHLNO-191004-1	Zfish	PMID:30467204
Biological Process	GO:0030148	sphingolipid biosynthetic process	Kdsr	IGI	SGD:S000000469	Mouse	PMID:15328338
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	kdsr	IGI	ZFIN:ZDB-GENO-191121-8	Zfish	PMID:30718751
Biological Process	GO:0006686	sphingomyelin biosynthetic process	kdsr	IMP	ZFIN:ZDB-GENO-191121-7	Zfish	PMID:30718751

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern