Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF1
  • Mouse genes Klf1
  • Rat genes Klf1
  • Zfish genes klf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Klf1	IDA		Mouse	PMID:22835905
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Klf1	IMP		Mouse	MGI:MGI:5822988|PMID:17442339
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Klf1	IDA		Mouse	MGI:MGI:5822988|PMID:17442339
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf1	IMP		Mouse	PMID:22835905
Molecular Function	GO:0003700	DNA-binding transcription factor activity	klf1	IDA		Zfish	PMID:18941117
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Klf1	IPI	UniProtKB:Q16594	Mouse	MGI:MGI:3850307|PMID:19251649
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P32776	Human	PMID:21670263
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P32780	Human	PMID:21670263
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q92793	Human	PMID:21670263
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:A5D8V6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P09234	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P13807	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P52597	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P79522	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:P98175	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q01085-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q07021	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q15365	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q2TAC2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q6ZRY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q92997	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q9BQ04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF1	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Klf1	IPI	UniProtKB:Q16594	Mouse	MGI:MGI:3850307|PMID:19251649
Molecular Function	GO:0019904	protein domain specific binding	Klf1	IPI	UniProtKB:Q16594	Mouse	MGI:MGI:3850307|PMID:19251649
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF1	IDA		Human	PMID:21539536
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf1	IDA		Mouse	MGI:MGI:5822988|PMID:17442339
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Molecular Function	GO:0043565	sequence-specific DNA binding	klf1	IDA		Zfish	PMID:18941117
Molecular Function	GO:0000976	transcription cis-regulatory region binding	KLF1	IDA		Human	PMID:20676099
Cellular Component	GO:0000785	chromatin	KLF1	IDA		Human	PMID:21539536
Cellular Component	GO:0000785	chromatin	klf1	IDA		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Cellular Component	GO:0005654	nucleoplasm	KLF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KLF1	IDA		Human	PMID:21055716
Cellular Component	GO:0005634	nucleus	KLF1	IDA		Human	PMID:25585695
Biological Process	GO:0031100	animal organ regeneration	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Biological Process	GO:0055007	cardiac muscle cell differentiation	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Biological Process	GO:0060038	cardiac muscle cell proliferation	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Biological Process	GO:0043697	cell dedifferentiation	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Biological Process	GO:1901653	cellular response to peptide	Klf1	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0006338	chromatin remodeling	Klf1	IDA		Mouse	PMID:15489291
Biological Process	GO:0006351	DNA-templated transcription	klf1	IDA		Zfish	PMID:18941117|ZFIN:ZDB-PUB-081028-10
Biological Process	GO:0035162	embryonic hemopoiesis	Klf1	IMP	MGI:MGI:1857557	Mouse	PMID:7753194
Biological Process	GO:0035162	embryonic hemopoiesis	Klf1	IMP	MGI:MGI:1861107	Mouse	PMID:19409822
Biological Process	GO:0048821	erythrocyte development	Klf1	IMP	MGI:MGI:1857162	Mouse	PMID:15923635
Biological Process	GO:0048821	erythrocyte development	Klf1	IMP	MGI:MGI:1857557	Mouse	PMID:7753194
Biological Process	GO:0030218	erythrocyte differentiation	KLF1	IMP		Human	PMID:21055716
Biological Process	GO:0030218	erythrocyte differentiation	Klf1	IMP		Mouse	PMID:22835905
Biological Process	GO:0043249	erythrocyte maturation	Klf1	IMP		Mouse	PMID:7753195
Biological Process	GO:0001701	in utero embryonic development	Klf1	IMP	MGI:MGI:1857557	Mouse	PMID:7753194
Biological Process	GO:0001889	liver development	Klf1	IMP	MGI:MGI:1857557	Mouse	PMID:7753194
Biological Process	GO:0060135	maternal process involved in female pregnancy	Klf1	IEP		Rat	PMID:18255020|RGD:4144779
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KLF1	IDA		Human	PMID:15084587
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KLF1	IDA		Human	PMID:20676099
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KLF1	IDA		Human	PMID:21055716
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf1	IDA		Mouse	MGI:MGI:3850307|PMID:19251649
Biological Process	GO:0010628	positive regulation of gene expression	Klf1	IMP		Mouse	PMID:22835905
Biological Process	GO:0010628	positive regulation of gene expression	klf1	IDA		Zfish	PMID:18941117
Biological Process	GO:0010628	positive regulation of gene expression	klf1	IMP		Zfish	PMID:18941117
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf1	IMP		Mouse	MGI:MGI:5822988|PMID:17442339
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf1	IDA		Mouse	MGI:MGI:3850307|PMID:19251649
Biological Process	GO:0060319	primitive erythrocyte differentiation	klf1	IEP		Zfish	PMID:18941117
Biological Process	GO:0006355	regulation of DNA-templated transcription	KLF1	IMP		Human	PMID:25585695
Biological Process	GO:0006355	regulation of DNA-templated transcription	klf1	IDA		Zfish	PMID:18941117|ZFIN:ZDB-PUB-081028-10
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4
Biological Process	GO:0045214	sarcomere organization	klf1	IMP		Zfish	PMID:33833125|ZFIN:ZDB-PUB-210410-4

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern