Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF12
  • Mouse genes Klf12
  • Rat genes Klf12
  • Zfish genes klf12a,klf12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	KLF12	IDA		Human	PMID:16615998
Molecular Function	GO:0003677	DNA binding	Klf12	IDA		Mouse	PMID:9858544
Molecular Function	GO:0003700	DNA-binding transcription factor activity	KLF12	IDA		Human	PMID:16615998
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf12	IDA		Mouse	PMID:16615998
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	KLF12	IDA		Human	PMID:10704285
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Klf12	IDA		Mouse	MGI:MGI:1321342|PMID:9858544
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q96KQ7	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q13363-2	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q13363-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q9NVV9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q13363-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q13643	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q14192	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q96KQ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:P23284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:P61981	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q15047-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF12	IPI	UniProtKB:Q96KQ7	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Klf12	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529|PMID:20599664
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF12	IDA		Human	PMID:10704285
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Klf12	IDA		Mouse	MGI:MGI:1321342|PMID:9858544
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KLF12	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	KLF12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF12	IDA		Human	GO_REF:0000052
Biological Process	GO:0006351	DNA-templated transcription	Klf12	IDA		Mouse	MGI:MGI:3623186|PMID:16615998
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF12	IDA		Human	PMID:16615998
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF12	IDA		Human	PMID:10704285
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Klf12	IDA		Mouse	MGI:MGI:1321342|PMID:9858544
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf12	IDA		Mouse	PMID:16615998
Biological Process	GO:0006355	regulation of DNA-templated transcription	Klf12	IDA		Mouse	MGI:MGI:3623186|PMID:16615998
Biological Process	GO:0006355	regulation of DNA-templated transcription	Klf12	IDA		Mouse	PMID:9858544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern