Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF2
  • Mouse genes Klf2
  • Rat genes Klf2
  • Zfish genes klf2a,klf2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	KLF2	IMP		Human	PMID:22327366
Molecular Function	GO:0003700	DNA-binding transcription factor activity	KLF2	IDA		Human	PMID:21063504
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	KLF2	IMP		Human	PMID:22327366
Molecular Function	GO:0005515	protein binding	KLF2	IPI	UniProtKB:Q92831	Human	PMID:16617118
Molecular Function	GO:0005515	protein binding	KLF2	IPI	UniProtKB:Q9HCE7	Human	PMID:21382345
Molecular Function	GO:0005515	protein binding	KLF2	IPI	UniProtKB:Q9HCE7-2	Human	PMID:21382345
Molecular Function	GO:0005515	protein binding	Klf2	IPI	UniProtKB:Q8BZZ3	Mouse	MGI:MGI:3688077|PMID:11375995
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KLF2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	klf2a	IDA		Zfish	PMID:21849483
Cellular Component	GO:0000785	chromatin	KLF2	IMP		Human	PMID:22327366
Cellular Component	GO:0005634	nucleus	Klf2	IDA		Mouse	PMID:22001906
Biological Process	GO:0001525	angiogenesis	klf2a	IGI	ZFIN:ZDB-MRPHLNO-141105-1,ZFIN:ZDB-MRPHLNO-141105-4	Zfish	PMID:23507969
Biological Process	GO:0003171	atrioventricular valve development	klf2a	IMP	ZFIN:ZDB-MRPHLNO-101105-1	Zfish	PMID:19924233
Biological Process	GO:0003171	atrioventricular valve development	klf2a	IMP	ZFIN:ZDB-MRPHLNO-101105-2	Zfish	PMID:19924233
Biological Process	GO:0003181	atrioventricular valve morphogenesis	klf2a	IMP	ZFIN:ZDB-GENO-161205-6	Zfish	PMID:27221222
Biological Process	GO:0000902	cell morphogenesis	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0071409	cellular response to cycloheximide	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071498	cellular response to fluid shear stress	KLF2	IMP		Human	PMID:22327366
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071347	cellular response to interleukin-1	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	KLF2	IMP		Human	PMID:23043106
Biological Process	GO:0071407	cellular response to organic cyclic compound	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:1901653	cellular response to peptide	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Klf2	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0097533	cellular stress response to acid chemical	KLF2	IMP		Human	PMID:26299712
Biological Process	GO:0061444	endocardial cushion cell development	klf2a	IMP	ZFIN:ZDB-MRPHLNO-101105-2	Zfish	PMID:19924233
Biological Process	GO:0061444	endocardial cushion cell development	klf2a	IMP	ZFIN:ZDB-MRPHLNO-101105-1	Zfish	PMID:19924233
Biological Process	GO:0040029	epigenetic regulation of gene expression	Klf2	IGI	MGI:MGI:3588194	Mouse	PMID:22482507
Biological Process	GO:0034101	erythrocyte homeostasis	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0043249	erythrocyte maturation	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0007507	heart development	klf2a	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-121102-1,ZFIN:ZDB-MRPHLNO-220309-2	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	klf2b	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-121102-1,ZFIN:ZDB-MRPHLNO-220309-2	Zfish	PMID:25625206
Biological Process	GO:0001701	in utero embryonic development	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:9859212
Biological Process	GO:0001701	in utero embryonic development	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0035264	multicellular organism growth	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Klf2	IMP		Rat	PMID:19192484|RGD:2316542
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	klf2a	IGI	ZFIN:ZDB-MRPHLNO-100610-8,ZFIN:ZDB-MRPHLNO-140217-1	Zfish	PMID:24211655
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	klf2b	IGI	ZFIN:ZDB-MRPHLNO-100610-8,ZFIN:ZDB-MRPHLNO-140217-1	Zfish	PMID:24211655
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	KLF2	IMP		Human	PMID:26299712
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF2	IDA		Human	PMID:26299712
Biological Process	GO:0006809	nitric oxide biosynthetic process	klf2a	IMP	ZFIN:ZDB-MRPHLNO-100610-8	Zfish	PMID:21849483
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KLF2	IDA		Human	PMID:21063504
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf2	IDA		Mouse	PMID:7565748
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf2	IMP		Rat	PMID:15540987|RGD:2316547
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	KLF2	IDA		Human	PMID:21768538
Biological Process	GO:0051247	positive regulation of protein metabolic process	KLF2	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0048386	positive regulation of retinoic acid receptor signaling pathway	KLF2	IDA		Human	PMID:26416422
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF2	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF2	IMP		Human	PMID:22327366
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf2	IMP	MGI:MGI:3047647	Mouse	PMID:15947087
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf2	IDA		Mouse	PMID:22001906
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	KLF2	IMP		Human	PMID:23043106
Biological Process	GO:0042665	regulation of ectodermal cell fate specification	klf2a	IGI	ZFIN:ZDB-MRPHLNO-100610-8,ZFIN:ZDB-MRPHLNO-140217-1	Zfish	PMID:24211655
Biological Process	GO:0042665	regulation of ectodermal cell fate specification	klf2b	IGI	ZFIN:ZDB-MRPHLNO-100610-8,ZFIN:ZDB-MRPHLNO-140217-1	Zfish	PMID:24211655
Biological Process	GO:0034616	response to laminar fluid shear stress	Klf2	IEP		Rat	PMID:16466697|RGD:2316544
Biological Process	GO:0060509	type I pneumocyte differentiation	Klf2	IMP		Mouse	PMID:22001906
Biological Process	GO:0042311	vasodilation	KLF2	IMP		Human	PMID:21768538
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	klf2a	IGI	ZFIN:ZDB-GENO-190606-27	Zfish	PMID:30592462
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	klf2b	IGI	ZFIN:ZDB-GENO-190606-27	Zfish	PMID:30592462

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern