Source |
Alliance of Genome Resources |
Category | ID | Classification term | Gene | Evidence | Inferred from | Organism | Reference |
---|---|---|---|---|---|---|---|
Molecular Function | GO:0008013 | beta-catenin binding | Klf4 | IPI | UniProtKB:Q02248 | Mouse | MGI:MGI:5428344|PMID:22723415 |
Molecular Function | GO:0031490 | chromatin DNA binding | Klf4 | IDA | Mouse | PMID:32467224 | |
Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | KLF4 | IMP | Human | PMID:21539536 | |
Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | Klf4 | IMP | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | Klf4 | IDA | Mouse | PMID:22306741 | |
Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | Klf4 | IDA | Rat | PMID:17659301|RGD:1643591 | |
Molecular Function | GO:0003700 | DNA-binding transcription factor activity | Klf4 | IDA | Mouse | PMID:17130451 | |
Molecular Function | GO:0003700 | DNA-binding transcription factor activity | Klf4 | IDA | Rat | PMID:12034813|RGD:619591 | |
Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | Klf4 | IDA | Mouse | MGI:MGI:6377804|PMID:28262547 | |
Molecular Function | GO:0003690 | double-stranded DNA binding | Klf4 | IDA | Rat | PMID:12034813|RGD:619591 | |
Molecular Function | GO:0042826 | histone deacetylase binding | Klf4 | IPI | RGD:619976 | Rat | PMID:19486889|RGD:9590233 |
Molecular Function | GO:0035014 | phosphatidylinositol 3-kinase regulator activity | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Molecular Function | GO:1990841 | promoter-specific chromatin binding | KLF4 | IDA | Human | PMID:27907090 | |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:Q13363 | Human | PMID:19751731 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:O95983 | Human | PMID:24048479 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:A0A024R8L2 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:O14964 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:O75031 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:P13807 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:P55771 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:Q08117-2 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | KLF4 | IPI | UniProtKB:Q92997 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:P20263|UniProtKB:P48432 | Mouse | MGI:MGI:4887542|PMID:19816951 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:Q3ULA2 | Mouse | MGI:MGI:6149282|PMID:29593216 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:P27361|UniProtKB:Q63844|UniProtKB:Q9UKB1|UniProtKB:Q9Y297 | Mouse | MGI:MGI:5914636|PMID:22307056 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:O95793 | Mouse | MGI:MGI:6114918|PMID:29374155 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:Q62315 | Mouse | MGI:MGI:5887185|PMID:26523946 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | UniProtKB:O88895 | Mouse | PMID:32467224 |
Molecular Function | GO:0005515 | protein binding | Klf4 | IPI | PR:E9Q6W4 | Mouse | PMID:24161396 |
Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | KLF4 | IDA | Human | PMID:21539536 | |
Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Klf4 | IDA | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Molecular Function | GO:0001010 | RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity | Klf4 | IDA | Mouse | MGI:MGI:4887558|PMID:18396140 | |
Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | KLF4 | IPI | UniProtKB:Q92793 | Human | PMID:21539536 |
Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | Klf4 | IPI | UniProtKB:P08152 | Mouse | MGI:MGI:4887558|PMID:18396140 |
Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | Klf4 | IPI | PR:P42227 | Mouse | PMID:24129709 |
Molecular Function | GO:0043565 | sequence-specific DNA binding | Klf4 | IDA | Mouse | PMID:8940147 | |
Molecular Function | GO:0043565 | sequence-specific DNA binding | Klf4 | IDA | Mouse | PMID:22306741 | |
Molecular Function | GO:0043565 | sequence-specific DNA binding | Klf4 | IDA | Rat | PMID:12034813|RGD:619591 | |
Molecular Function | GO:0043565 | sequence-specific DNA binding | Klf4 | IDA | Rat | PMID:15632413|RGD:1643534 | |
Molecular Function | GO:0043565 | sequence-specific DNA binding | Klf4 | IDA | Rat | PMID:17659301|RGD:1643591 | |
Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding | KLF4 | IDA | Human | PMID:28473536 | |
Molecular Function | GO:0000976 | transcription cis-regulatory region binding | Klf4 | IDA | Mouse | MGI:MGI:4887334|PMID:16954384 | |
Molecular Function | GO:0000976 | transcription cis-regulatory region binding | Klf4 | IDA | Mouse | PMID:24161396 | |
Molecular Function | GO:0000976 | transcription cis-regulatory region binding | Klf4 | IDA | Rat | PMID:19531492|RGD:8553301 | |
Molecular Function | GO:0001221 | transcription coregulator binding | Klf4 | IPI | RGD:620036 | Rat | PMID:21252119|RGD:7364714 |
Cellular Component | GO:0000785 | chromatin | KLF4 | IDA | Human | PMID:21539536 | |
Cellular Component | GO:0000785 | chromatin | Klf4 | IDA | Rat | PMID:15632413|RGD:1643534 | |
Cellular Component | GO:0005737 | cytoplasm | Klf4 | IDA | Mouse | PMID:24129709 | |
Cellular Component | GO:0005829 | cytosol | KLF4 | IDA | Human | GO_REF:0000052 | |
Cellular Component | GO:0000791 | euchromatin | Klf4 | IDA | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Cellular Component | GO:0015630 | microtubule cytoskeleton | KLF4 | IDA | Human | GO_REF:0000052 | |
Cellular Component | GO:0005654 | nucleoplasm | KLF4 | IDA | Human | GO_REF:0000052 | |
Cellular Component | GO:0005634 | nucleus | Klf4 | IPI | UniProtKB:O88895 | Mouse | PMID:32467224 |
Cellular Component | GO:0005634 | nucleus | Klf4 | IDA | Mouse | PMID:19796622 | |
Cellular Component | GO:0005634 | nucleus | Klf4 | IDA | Mouse | PMID:24161396 | |
Cellular Component | GO:0005634 | nucleus | Klf4 | IDA | Mouse | PMID:24129709 | |
Cellular Component | GO:0005634 | nucleus | Klf4 | IDA | Rat | PMID:15632413|RGD:1643534 | |
Cellular Component | GO:0005667 | transcription regulator complex | Klf4 | IDA | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Cellular Component | GO:0005667 | transcription regulator complex | Klf4 | IDA | Rat | PMID:15632413|RGD:1643534 | |
Biological Process | GO:0060070 | canonical Wnt signaling pathway | Klf4 | IMP | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Biological Process | GO:0071409 | cellular response to cycloheximide | Klf4 | IEP | Rat | PMID:18406357|RGD:2316543 | |
Biological Process | GO:0071363 | cellular response to growth factor stimulus | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide | Klf4 | IEP | Rat | PMID:18406357|RGD:2316543 | |
Biological Process | GO:0071499 | cellular response to laminar fluid shear stress | KLF4 | IMP | Human | PMID:22430140 | |
Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor | Klf4 | IEP | Mouse | PMID:20439489 | |
Biological Process | GO:0071407 | cellular response to organic cyclic compound | Klf4 | IEP | Rat | PMID:18406357|RGD:2316543 | |
Biological Process | GO:1901653 | cellular response to peptide | Klf4 | IEP | Rat | PMID:18406357|RGD:2316543 | |
Biological Process | GO:0071300 | cellular response to retinoic acid | Klf4 | IEP | Rat | PMID:19486889|RGD:9590233 | |
Biological Process | GO:0002357 | defense response to tumor cell | KLF4 | IMP | Human | PMID:30429596 | |
Biological Process | GO:0006351 | DNA-templated transcription | Klf4 | IMP | Mouse | MGI:MGI:5485298|PMID:23372771 | |
Biological Process | GO:0009913 | epidermal cell differentiation | Klf4 | IMP | MGI:MGI:2183936 | Mouse | PMID:10431239 |
Biological Process | GO:0008544 | epidermis development | Klf4 | IMP | MGI:MGI:2183917 | Mouse | PMID:32467224 |
Biological Process | GO:0048730 | epidermis morphogenesis | Klf4 | IMP | MGI:MGI:2183936 | Mouse | PMID:10431239 |
Biological Process | GO:0061436 | establishment of skin barrier | Klf4 | IMP | MGI:MGI:2183917 | Mouse | PMID:32467224 |
Biological Process | GO:0045444 | fat cell differentiation | Klf4 | IMP | Mouse | MGI:MGI:4887558|PMID:18396140 | |
Biological Process | GO:0045444 | fat cell differentiation | Klf4 | IMP | Mouse | PMID:22306741 | |
Biological Process | GO:0010467 | gene expression | Klf4 | IMP | Mouse | PMID:27208706 | |
Biological Process | GO:0010467 | gene expression | Klf4 | IMP | MGI:MGI:2183917 | Mouse | PMID:32467224 |
Biological Process | GO:0002067 | glandular epithelial cell differentiation | Klf4 | IMP | MGI:MGI:2183917,MGI:MGI:3045749 | Mouse | PMID:17060454 |
Biological Process | GO:0016525 | negative regulation of angiogenesis | KLF4 | IDA | Human | PMID:23867820 | |
Biological Process | GO:0030336 | negative regulation of cell migration | Klf4 | IMP | Mouse | MGI:MGI:5445064|PMID:22491752 | |
Biological Process | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0008285 | negative regulation of cell population proliferation | Klf4 | IDA | Mouse | PMID:8702718 | |
Biological Process | GO:0008285 | negative regulation of cell population proliferation | klf4 | IMP | ZFIN:ZDB-MRPHLNO-111014-1,ZFIN:ZDB-MRPHLNO-111014-2 | Zfish | PMID:21687630 |
Biological Process | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0043433 | negative regulation of DNA-binding transcription factor activity | Klf4 | IMP | Mouse | PMID:24129709 | |
Biological Process | GO:0045892 | negative regulation of DNA-templated transcription | KLF4 | IDA | Human | PMID:9422764 | |
Biological Process | GO:0045892 | negative regulation of DNA-templated transcription | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | KLF4 | IDA | Human | PMID:23867820 | |
Biological Process | GO:0010629 | negative regulation of gene expression | KLF4 | IGI | RNAcentral:URS00003768C5_9606 | Human | PMID:22267480 |
Biological Process | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0032717 | negative regulation of interleukin-8 production | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:1904998 | negative regulation of leukocyte adhesion to arterial endothelial cell | KLF4 | IGI | RNAcentral:URS00003768C5_9606 | Human | PMID:22267480 |
Biological Process | GO:0014740 | negative regulation of muscle hyperplasia | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:0051898 | negative regulation of protein kinase B signaling | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:0060761 | negative regulation of response to cytokine stimulus | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation | Klf4 | IDA | Rat | PMID:17659301|RGD:1643591 | |
Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation | Klf4 | IMP | Rat | PMID:19531492|RGD:8553301 | |
Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II | KLF4 | IDA | Human | PMID:20551324 | |
Biological Process | GO:1904798 | positive regulation of core promoter binding | Klf4 | IMP | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription | KLF4 | IDA | Human | PMID:27431648 | |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription | Klf4 | IDA | Mouse | MGI:MGI:4887334|PMID:16954384 | |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription | Klf4 | IDA | Mouse | MGI:MGI:4887542|PMID:19816951 | |
Biological Process | GO:0010628 | positive regulation of gene expression | KLF4 | IGI | RNAcentral:URS00003768C5_9606 | Human | PMID:22267480 |
Biological Process | GO:0046985 | positive regulation of hemoglobin biosynthetic process | KLF4 | IMP | Human | PMID:21539536 | |
Biological Process | GO:1902895 | positive regulation of miRNA transcription | KLF4 | IDA | Human | PMID:23867820 | |
Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process | KLF4 | IMP | Human | PMID:22430140 | |
Biological Process | GO:0051247 | positive regulation of protein metabolic process | KLF4 | IGI | UniProtKB:Q62862 | Human | PMID:20551324 |
Biological Process | GO:0051247 | positive regulation of protein metabolic process | KLF4 | IMP | Human | PMID:22430140 | |
Biological Process | GO:1903672 | positive regulation of sprouting angiogenesis | KLF4 | IGI | RNAcentral:URS0000591950_9606 | Human | PMID:27431648 |
Biological Process | GO:0051973 | positive regulation of telomerase activity | KLF4 | IDA | Human | PMID:20629177 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | KLF4 | IGI | UniProtKB:Q62862 | Human | PMID:20551324 |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | KLF4 | IMP | Human | PMID:22430140 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | KLF4 | IMP | Human | PMID:22723415 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | KLF4 | IMP | Human | PMID:27907090 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IMP | Mouse | MGI:MGI:5428344|PMID:22723415 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Mouse | MGI:MGI:6377809|PMID:26691508 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IMP | Mouse | MGI:MGI:4887558|PMID:18396140 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IMP | Mouse | PMID:22306741 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Mouse | PMID:24161396 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Mouse | PMID:17130451 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Mouse | PMID:17060454 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Rat | PMID:12034813|RGD:619591 | |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II | Klf4 | IDA | Rat | PMID:17659301|RGD:1643591 | |
Biological Process | GO:0031077 | post-embryonic camera-type eye development | Klf4 | IMP | MGI:MGI:2183917,MGI:MGI:3045749 | Mouse | PMID:17060454 |
Biological Process | GO:0035166 | post-embryonic hemopoiesis | KLF4 | IMP | Human | PMID:21539536 | |
Biological Process | GO:0048679 | regulation of axon regeneration | Klf4 | IGI | MGI:MGI:103038 | Mouse | PMID:24129709 |
Biological Process | GO:0048679 | regulation of axon regeneration | Klf4 | IMP | Mouse | PMID:24129709 | |
Biological Process | GO:0120222 | regulation of blastocyst development | Klf4 | IMP | MGI:MGI:6392146 | Mouse | PMID:29593216 |
Biological Process | GO:0045595 | regulation of cell differentiation | Klf4 | IDA | Mouse | MGI:MGI:4887542|PMID:19816951 | |
Biological Process | GO:0042127 | regulation of cell population proliferation | Klf4 | IGI | MGI:MGI:88039 | Mouse | PMID:17671182 |
Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II | Klf4 | IDA | Mouse | PMID:19796622 | |
Biological Process | GO:0010033 | response to organic substance | Klf4 | IDA | Mouse | PMID:18400104 | |
Biological Process | GO:0032526 | response to retinoic acid | Klf4 | IDA | Mouse | PMID:18400104 | |
Biological Process | GO:0035019 | somatic stem cell population maintenance | Klf4 | IDA | Mouse | PMID:15358627 | |
Biological Process | GO:0019827 | stem cell population maintenance | Klf4 | IDA | Mouse | MGI:MGI:4887542|PMID:19816951 | |
Biological Process | GO:0072089 | stem cell proliferation | klf4 | IMP | ZFIN:ZDB-GENO-200220-22 | Zfish | PMID:30933982 |
Biological Process | GO:0006366 | transcription by RNA polymerase II | Klf4 | IMP | Mouse | PMID:22306741 |
EXP Inferred from experiment |
IDA Inferred from direct assay |
IEP Inferred from expression pattern |
IGI Inferred from genetic interaction |
IMP Inferred from mutant phenotype |
IPI Inferred from physical interaction |
HTP Inferred from High Throughput Experiment |
HDA Inferred from High Throughput Direct Assay |
HMP Inferred from High Throughput Mutant Phenotype |
HGI Inferred from High Throughput Genetic Interaction |
HEP Inferred from High Throughput Expression Pattern |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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