Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF5
  • Mouse genes Klf5
  • Rat genes Klf5
  • Zfish genes klf5a,klf5b,klf5l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Klf5	IDA		Mouse	PMID:12101409
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	KLF5	IDA		Human	PMID:16595680
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf5	IMP	MGI:MGI:3038696	Mouse	PMID:12101409
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Klf5	IGI	MGI:MGI:99532	Mouse	PMID:27743478
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Klf5	IGI	MGI:MGI:97275,MGI:MGI:99532	Mouse	PMID:27743478
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Klf5	IGI	MGI:MGI:97275	Mouse	PMID:27743478
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Klf5	IDA		Mouse	PMID:27743478
Molecular Function	GO:0043426	MRF binding	Klf5	IPI	PR:P10085	Mouse	PMID:27743478
Molecular Function	GO:0043426	MRF binding	Klf5	IPI	PR:Q60929	Mouse	PMID:27743478
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P0CG48	Human	PMID:17320083
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P28331-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:Q96A83-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:Q9BVL2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:Q9UMF0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P46937	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	KLF5	IPI	UniProtKB:P54253	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Klf5	IPI	UniProtKB:Q969H0	Mouse	MGI:MGI:5914636|PMID:22307056
Molecular Function	GO:0005515	protein binding	Klf5	IPI	PR:P11416	Mouse	PMID:12101409
Molecular Function	GO:0005515	protein binding	Klf5	IPI	RGD:619976|RGD:3534	Rat	PMID:21383775|RGD:9590238
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF5	IDA		Human	PMID:16595680
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf5	IGI	MGI:MGI:97275	Mouse	PMID:27743478
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf5	IGI	MGI:MGI:99532	Mouse	PMID:27743478
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf5	IGI	MGI:MGI:97275,MGI:MGI:99532	Mouse	PMID:27743478
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf5	IDA		Mouse	PMID:27743478
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf5	IDA		Rat	PMID:21383775|RGD:9590238
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KLF5	IDA		Human	PMID:28473536
Cellular Component	GO:0005794	Golgi apparatus	KLF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KLF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Klf5	IDA		Mouse	PMID:27743478
Cellular Component	GO:0005634	nucleus	Klf5	IDA		Mouse	PMID:21503901
Cellular Component	GO:0005667	transcription regulator complex	Klf5	IDA		Mouse	PMID:27743478
Biological Process	GO:0001525	angiogenesis	Klf5	IMP	MGI:MGI:3038696	Mouse	PMID:12101409
Biological Process	GO:0099156	cell-cell signaling via exosome	KLF5	IDA		Human	PMID:28408180
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Klf5	IEP		Mouse	PMID:20439489
Biological Process	GO:0071407	cellular response to organic cyclic compound	Klf5	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:1901653	cellular response to peptide	Klf5	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0048565	digestive tract development	klf5a	IMP	ZFIN:ZDB-MRPHLNO-120726-3	Zfish	PMID:22609551
Biological Process	GO:0048565	digestive tract development	klf5a	IMP	ZFIN:ZDB-MRPHLNO-120726-2	Zfish	PMID:22609551
Biological Process	GO:0060576	intestinal epithelial cell development	Klf5	IMP	MGI:MGI:3806635	Mouse	PMID:23266329
Biological Process	GO:0030033	microvillus assembly	Klf5	IMP	MGI:MGI:3038696	Mouse	PMID:12101409
Biological Process	GO:0014908	myotube differentiation involved in skeletal muscle regeneration	Klf5	IDA		Mouse	PMID:27743478
Biological Process	GO:0014908	myotube differentiation involved in skeletal muscle regeneration	Klf5	IMP		Mouse	PMID:27743478
Biological Process	GO:0014908	myotube differentiation involved in skeletal muscle regeneration	Klf5	IMP	MGI:MGI:4353154,MGI:MGI:4421792	Mouse	PMID:27743478
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Klf5	IDA		Mouse	PMID:23266329
Biological Process	GO:0008284	positive regulation of cell population proliferation	Klf5	IEP		Rat	PMID:14726538|RGD:1304288
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf5	IMP	MGI:MGI:3038696	Mouse	PMID:12101409
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Klf5	IMP		Mouse	PMID:20719859
Biological Process	GO:1902895	positive regulation of miRNA transcription	KLF5	IDA		Human	PMID:28408180
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF5	IDA		Human	PMID:16595680
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf5	IDA		Mouse	PMID:27743478
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf5	IGI	MGI:MGI:99532	Mouse	PMID:27743478
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf5	IGI	MGI:MGI:97275	Mouse	PMID:27743478
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf5	IGI	MGI:MGI:97275,MGI:MGI:99532	Mouse	PMID:27743478
Biological Process	GO:0061586	positive regulation of transcription by transcription factor localization	Klf5	IDA		Mouse	PMID:27743478
Biological Process	GO:0010468	regulation of gene expression	Klf5	IMP		Mouse	PMID:27743478
Biological Process	GO:0032534	regulation of microvillus assembly	Klf5	IMP	MGI:MGI:3806635	Mouse	PMID:23266329
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Klf5	IMP	MGI:MGI:3806635	Mouse	PMID:23266329
Biological Process	GO:0014901	satellite cell activation involved in skeletal muscle regeneration	Klf5	IMP	MGI:MGI:4353154,MGI:MGI:4421792	Mouse	PMID:27743478
Biological Process	GO:0035914	skeletal muscle cell differentiation	Klf5	IMP		Mouse	PMID:22147266
Biological Process	GO:0014816	skeletal muscle satellite cell differentiation	Klf5	IMP	MGI:MGI:4353154,MGI:MGI:4421792	Mouse	PMID:27743478
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Klf5	IMP	MGI:MGI:4353154,MGI:MGI:4421792	Mouse	PMID:27743478

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern