Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF6
  • Mouse genes Klf6
  • Rat genes Klf6
  • Zfish genes klf6a,klf6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	klf6a	IDA		Zfish	PMID:26015096
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	klf6a	IDA		Zfish	PMID:20123021
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	KLF6	IDA		Human	PMID:18755691
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf6	IDA		Rat	PMID:9689109|RGD:62381
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	klf6a	IDA		Zfish	ZFIN:ZDB-PUB-170815-11
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	klf6a	IDA		Zfish	PMID:28803829
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	klf6a	IDA		Zfish	PMID:26015096
Molecular Function	GO:0003690	double-stranded DNA binding	Klf6	IDA		Rat	PMID:9689109|RGD:62381
Molecular Function	GO:0005515	protein binding	KLF6	IPI	UniProtKB:Q04206	Human	PMID:24634218
Molecular Function	GO:0005515	protein binding	KLF6	IPI	UniProtKB:P02545	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF6	IPI	UniProtKB:P41250	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF6	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLF6	IPI	UniProtKB:O43149	Human	PMID:33227311
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF6	IDA		Human	PMID:18755691
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KLF6	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	klf6a	IDA		Zfish	ZFIN:ZDB-PUB-170815-11
Cellular Component	GO:0000785	chromatin	klf6a	IDA		Zfish	PMID:28803829
Cellular Component	GO:0005737	cytoplasm	Klf6	IDA		Mouse	PMID:15557439
Cellular Component	GO:0005829	cytosol	KLF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	KLF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KLF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	KLF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Klf6	IDA		Mouse	PMID:15557439
Cellular Component	GO:0005634	nucleus	Klf6	IDA		Rat	PMID:9689109|RGD:62381
Biological Process	GO:0031532	actin cytoskeleton reorganization	klf6a	IMP	ZFIN:ZDB-MRPHLNO-221103-1	Zfish	PMID:34319989
Biological Process	GO:0071409	cellular response to cycloheximide	Klf6	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Klf6	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071407	cellular response to organic cyclic compound	Klf6	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:1901653	cellular response to peptide	Klf6	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Klf6	IDA		Mouse	PMID:10880228
Biological Process	GO:0048565	digestive tract development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-6	Zfish	PMID:20430021
Biological Process	GO:0048565	digestive tract development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-7	Zfish	PMID:20430021
Biological Process	GO:0043542	endothelial cell migration	klf6a	IMP	ZFIN:ZDB-MRPHLNO-221103-1	Zfish	PMID:34319989
Biological Process	GO:0043249	erythrocyte maturation	klf6a	IMP	ZFIN:ZDB-MRPHLNO-080208-5	Zfish	PMID:26015096
Biological Process	GO:0001889	liver development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-7	Zfish	PMID:20430021
Biological Process	GO:0001889	liver development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-6	Zfish	PMID:20430021
Biological Process	GO:0021634	optic nerve formation	klf6a	IDA		Zfish	PMID:20123021
Biological Process	GO:0035265	organ growth	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-6	Zfish	PMID:20430021
Biological Process	GO:0035265	organ growth	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-7	Zfish	PMID:20430021
Biological Process	GO:0031016	pancreas development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-7	Zfish	PMID:20430021
Biological Process	GO:0031016	pancreas development	klf6a	IMP	ZFIN:ZDB-MRPHLNO-100811-6	Zfish	PMID:20430021
Biological Process	GO:1905205	positive regulation of connective tissue replacement	Klf6	IMP		Mouse	MGI:MGI:5447902|PMID:22820290
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF6	IDA		Human	PMID:18755691
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf6	IDA		Rat	PMID:9689109|RGD:62381
Biological Process	GO:2000471	regulation of hematopoietic stem cell migration	klf6a	IMP	ZFIN:ZDB-GENO-180215-3	Zfish	PMID:28803829
Biological Process	GO:2000471	regulation of hematopoietic stem cell migration	klf6a	IGI	ZFIN:ZDB-GENE-110222-2	Zfish	PMID:28803829
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	klf6a	IGI	ZFIN:ZDB-GENE-110222-2	Zfish	PMID:28803829
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	klf6a	IMP	ZFIN:ZDB-GENO-180215-3	Zfish	PMID:28803829
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	klf6a	IDA		Zfish	ZFIN:ZDB-PUB-170815-11
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	klf6a	IDA		Zfish	PMID:28803829
Biological Process	GO:0042060	wound healing	Klf6	IEP		Rat	PMID:9689109|RGD:62381

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern