Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF7
  • Mouse genes Klf7
  • Rat genes
  • Zfish genes klf7a,klf7b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	klf7b	IDA		Zfish	PMID:20123021
Molecular Function	GO:0003677	DNA binding	Klf7	IDA		Mouse	PMID:15964824
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	KLF7	IDA		Human	PMID:9774444
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf7	IDA		Mouse	PMID:15964824
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	KLF7	IDA		Human	PMID:9774444
Molecular Function	GO:0005515	protein binding	Klf7	IPI	UniProtKB:Q8BMI0	Mouse	MGI:MGI:6294331|PMID:14729953
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF7	IDA		Human	PMID:9774444
Cellular Component	GO:0005829	cytosol	KLF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KLF7	IDA		Human	PMID:9774444
Biological Process	GO:0007411	axon guidance	Klf7	IMP	MGI:MGI:3581890	Mouse	PMID:15964824
Biological Process	GO:0007409	axonogenesis	Klf7	IMP	MGI:MGI:3581890	Mouse	PMID:15964824
Biological Process	GO:0048813	dendrite morphogenesis	Klf7	IMP	MGI:MGI:3581890	Mouse	PMID:15964824
Biological Process	GO:0042593	glucose homeostasis	KLF7	IMP		Human	PMID:16339272
Biological Process	GO:1904178	negative regulation of adipose tissue development	KLF7	IMP		Human	PMID:16339272
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	KLF7	IMP		Human	PMID:16339272
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF7	IMP		Human	PMID:16339272
Biological Process	GO:0021634	optic nerve formation	klf7b	IDA		Zfish	PMID:20123021
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf7	IDA		Mouse	PMID:15964824
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF7	IDA		Human	PMID:9774444
Biological Process	GO:0045604	regulation of epidermal cell differentiation	KLF7	IMP		Human	PMID:28916725

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern