Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF8
  • Mouse genes Klf8
  • Rat genes Klf8
  • Zfish genes klf8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	KLF8	IDA		Human	PMID:10756197
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	KLF8	IMP		Human	PMID:10756197
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF8	IDA		Human	PMID:10756197
Cellular Component	GO:0016235	aggresome	KLF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	KLF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF8	IDA		Human	GO_REF:0000052
Biological Process	GO:0021707	cerebellar granule cell differentiation	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-3	Zfish	PMID:25528982
Biological Process	GO:0021707	cerebellar granule cell differentiation	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-5,ZFIN:ZDB-MRPHLNO-150928-6	Zfish	PMID:25528982
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-5,ZFIN:ZDB-MRPHLNO-150928-6	Zfish	PMID:25528982
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-3	Zfish	PMID:25528982
Biological Process	GO:0021549	cerebellum development	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-5,ZFIN:ZDB-MRPHLNO-150928-6	Zfish	PMID:25528982
Biological Process	GO:0021549	cerebellum development	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-3	Zfish	PMID:25528982
Biological Process	GO:0021549	cerebellum development	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-4	Zfish	PMID:25528982
Biological Process	GO:0061966	establishment of left/right asymmetry	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-3	Zfish	PMID:28716076
Biological Process	GO:0061966	establishment of left/right asymmetry	klf8	IMP	ZFIN:ZDB-MRPHLNO-150928-4	Zfish	PMID:28716076
Biological Process	GO:0061966	establishment of left/right asymmetry	klf8	IMP	ZFIN:ZDB-GENO-180607-12	Zfish	PMID:28716076
Biological Process	GO:0061966	establishment of left/right asymmetry	klf8	IMP	ZFIN:ZDB-GENO-180607-11	Zfish	PMID:28716076
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF8	IMP		Human	PMID:10756197

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern